Extraventricular Choroid Plexus Carcinoma with Spinal Metastasis: A Case Report

Rachmat Andi Hartanto; Daniel Agriva Tamba; Nurhuda Hendra Setyawan; Ericko  Ekaputra; Rusdy Ghazali  Malueka; Indra Sari Kusuma  Harahap; Ery Kus  Dwianingsih

doi:10.3889/oamjms.2021.6240

Authors

Rachmat Andi Hartanto Department of Surgery, Division of Neurosurgery, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Dr. Sardjito General Hospital, Yogyakarta, Indonesia
Daniel Agriva Tamba Department of Surgery, Division of Neurosurgery, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Dr. Sardjito General Hospital, Yogyakarta, Indonesia
Nurhuda Hendra Setyawan Department of Radiology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada,Dr. Sardjito General Hospital, Yogyakarta, Indonesia https://orcid.org/0000-0001-5782-5933
Ericko Ekaputra Department of Radiology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada,Dr. Sardjito General Hospital, Yogyakarta, Indonesia https://orcid.org/0000-0003-0310-0528
Rusdy Ghazali Malueka Department of Neurology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada,Dr. Sardjito General Hospital, Yogyakarta, Indonesia https://orcid.org/0000-0001-6835-0638
Indra Sari Kusuma Harahap Department of Neurology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada,Dr. Sardjito General Hospital, Yogyakarta, Indonesia
Ery Kus Dwianingsih Department of Anatomical Pathology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada,Dr. Sardjito General Hospital, Yogyakarta, Indonesia https://orcid.org/0000-0002-0484-7773

DOI:

https://doi.org/10.3889/oamjms.2021.6240

Keywords:

Choroid plexus carcinoma, Extraventricular, Spinal metastasis

Abstract

We report a case of extraventricular choroid plexus carcinoma (CPC) accompanied by spinal metastasis in a pediatric patient. A 15-year-old female patient presented with chronic progressive headache and blurry vision. Magnetic resonance imaging (MRI) revealed an intra-axial mass in the left frontal lobe. A gross total resection was performed, and the histopathological examination revealed the diagnosis of CPC, confirmed with immunohistochemical (IHC) analysis of GFAP, S100, EM, P53 and Ki67. Eleven months later, MRI result identified another mass in the left frontal lobe. Spinal MRI showed drop metastasis to the spine, accompanied by leptomeningeal seeding. This case demonstrated the importance of IHC and spinal MRI in the management of CPC. This case report may provide more insight into extraventricular CPC cases, which is important for the adequate management of patients with CPC in the future.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Plum Analytics Artifact Widget Block

References

Gupta N. Choroid plexus tumors. In: Pediatric CNS Tumors. Berlin, Germany: Springer International Publishing; 2017. p. 187-98. https://doi.org/10.1007/978-3-319-30789-3_9 DOI: https://doi.org/10.1007/978-3-319-30789-3_9

Cannon DM, Mohindra P, Gondi V, Kruser TJ, Kozak KR. Choroid plexus tumor epidemiology and outcomes: Implications for surgical and radiotherapeutic management. J Neurooncol. 2015;121(1):151-7. https://doi.org/10.1007/s11060-014-1616-x PMid:25270349 DOI: https://doi.org/10.1007/s11060-014-1616-x

Wolff JE, Sajedi M, Brant R, Coppes MJ, Egeler RM. Choroid plexus tumours. Br J Cancer. 2002;87(10):1086-91. https://doi.org/10.1038/sj.bjc.6600609 PMid:12402146 DOI: https://doi.org/10.1038/sj.bjc.6600609

Stevens EA, Stanton CA, Nichols K, Ellis TL. Rare intraparenchymal choroid plexus carcinoma resembling atypical teratoid/rhabdoid tumor diagnosed by immunostaining for INI1 protein. J Neurosurg Pediatr. 2009;4(4):368-71. https://doi.org/10.3171/2009.5.peds0955 PMid:19795969 DOI: https://doi.org/10.3171/2009.5.PEDS0955

Carter AB, Price DL, Tucci KA, Lewis GK, Mewborne J, Singh HK. Choroid plexus carcinoma presenting as an intraparenchymal mass. J Neurosurg. 2001;95(6):1040-4. https://doi.org/10.3171/jns.2001.95.6.1040 PMid:11765820 DOI: https://doi.org/10.3171/jns.2001.95.6.1040

Lozier AP, Arbaje YM, Scheithauer BW. Supratentorial, extraventricular choroid plexus carcinoma in an adult: Case report. Neurosurgery. 2009;65(4):E816-7. https://doi.org/10.1227/01.neu.0000348291.48810.c2 PMid:19834361 DOI: https://doi.org/10.1227/01.NEU.0000348291.48810.C2

Greene RC. Extraventricular and intra-cerebellar papilloma of the choroid plexus. J Neuropathol Exp Neurol. 1951;10(2):204-7. https://doi.org/10.1097/00005072-195104000-00007 PMid:14824975 DOI: https://doi.org/10.1097/00005072-195104000-00007

Gopal P, Parker JR, Debski R, Parker JC. Choroid plexus carcinoma. Arch Pathol Lab Med. 2008;132(8):1350-4. https://doi.org/10.5858/2008-132-1350-cpc PMid:18684041 DOI: https://doi.org/10.5858/2008-132-1350-CPC

Sun S, Wang J, Zhu M, Beejadhursing R, Gao P, Zhang X, et al. Clinical, radiological, and histological features and treatment outcomes of supratentorial extraventricular ependymoma: 14 cases from a single center. J Neurosurg. 2018;128(5):1396-402. https://doi.org/10.3171/2017.1.jns161422 PMid:28686116 DOI: https://doi.org/10.3171/2017.1.JNS161422

Bettegowda C, Adogwa O, Mehta V, Chaichana KL, Weingart J, Carson BS, et al. Treatment of choroid plexus tumors: A 20-year single institutional experience. J Neurosurg Pediatr. 2012;10(5):398-405. https://doi.org/10.3171/2012.8.peds12132 PMid:22938081 DOI: https://doi.org/10.3171/2012.8.PEDS12132

Hosmann A, Hinker F, Dorfer C, Slavc I, Haberler C, Dieckmann K, et al. Management of choroid plexus tumors-an institutional experience. Acta Neurochir (Wien). 2019;161(4):745-54. https://doi.org/10.1007/s00701-019-03832-55 PMid:30783805 DOI: https://doi.org/10.1007/s00701-019-03832-5

Samuel T, Parikh J, Sharma S, Giller C, Sterling K, Kapoor S, et al. Recurrent adult choroid plexus carcinoma treated with high-dose chemotherapy and syngeneic stem cell (bone marrow) transplant. J Neurol Surg Part A Cent Eur Neurosurg. 2013;74(1):e149-54. https://doi.org/10.1055/s-0032-1333419 PMid:23427033 DOI: https://doi.org/10.1055/s-0032-1333419

Sawaishi Y, Yano T, Yoshida Y, Ito Y, Mizoi K, Hirayama A, et al. Choroid plexus carcinoma presented with spinal dysfunction caused by a drop metastasis: A case report. J Neurooncol. 2003;63(1):75-9. PMid:12814258

Baksh BS, Sinha N, Salehi A, Han RH, Miller BA, Dahiya S, et al. Widely metastatic choroid plexus carcinoma associated with novel TP53 somatic mutation. World Neurosurg. 2018;119:233-6. https://doi.org/10.1016/j.wneu.2018.07.284 PMid:30099178 DOI: https://doi.org/10.1016/j.wneu.2018.07.284

Taylor MB, Jackson RW, Hughes DG, Wright NB. Magnetic resonance imaging in the diagnosis and management of choroid plexus carcinoma in children. Pediatr Radiol. 2001;31(9):624-30. https://doi.org/10.1007/s002470100511 PMid:11512001 DOI: https://doi.org/10.1007/s002470100511

Van Der Ree TC, Dippel DW, Avezaat CJ, Sillevis Smitt PA, Vecht CJ, Van Den Bent MJ. Leptomeningeal metastasis after surgical resection of brain metastases. J Neurol Neurosurg Psychiatry. 1999;66(2):225-7. https://doi.org/10.1136/jnnp.66.2.225 PMid:10071105 DOI: https://doi.org/10.1136/jnnp.66.2.225

Norris LK, Grossman SA, Olivi A. Neoplastic meningitis following surgical resection of isolated cerebellar metastasis: A potentially preventable complication. J Neurooncol. 1997;32(3):215-23. PMid:9049883 DOI: https://doi.org/10.1023/A:1005723801479

Wolff JE, Sajedi M, Coppes MJ, Anderson RA, Egeler RM. Radiation therapy and survival in choroid plexus carcinoma. Lancet. 1999;353(9170):2126. https://doi.org/10.1016/s0140-6736(99)01744-4 PMid:10382700 DOI: https://doi.org/10.1016/S0140-6736(99)01744-4

Wrede B, Liu P, Wolff JE. Chemotherapy improves the survival of patients with choroid plexus carcinoma: A meta-analysis of individual cases with choroid plexus tumors. J Neurooncol. 2007;85(3):345-51. https://doi.org/10.1007/s11060-007-9428-x PMid:17576522 DOI: https://doi.org/10.1007/s11060-007-9428-x

Sun MZ, Ivan ME, Oh MC, Delance AR, Clark AJ, Safaee M, et al. Effects of adjuvant chemotherapy and radiation on overall survival in children with choroid plexus carcinoma. J Neurooncol. 2014;120(2):353-60. https://doi.org/10.1007/s11060-014-1559-2 PMid:25106865 DOI: https://doi.org/10.1007/s11060-014-1559-2