25-Hydroxy Vitamin D, Adiponectin Levels and Cardiometabolic Risk Factors in a Sample of Obese Children

Authors

  • Nayera E. Hassan Biological Anthropology Department, Medical Research Division, National Research Centre, Dokki, Giza
  • Sahar A. El-Masry Biological Anthropology Department, Medical Research Division, National Research Centre, Dokki, Giza
  • Rokia A. El Banna Biological Anthropology Department, Medical Research Division, National Research Centre, Dokki, Giza
  • Mones M. Abu Shady Child Health Department, Medical Research Division, National Research Centre, Dokki, Giza
  • Muhammad Al-Tohamy Biological Anthropology Department, Medical Research Division, National Research Centre, Dokki, Giza
  • Manal Mouhamed Ali Biological Anthropology Department, Medical Research Division, National Research Centre, Dokki, Giza
  • Mehrevan M. Abd El-Moniem Medical Biochemistry Department, Medical Research Division, National Research Centre, Dokki, Giza
  • Mona Anwar Children with Special Needs Department, Medical Research Division, National Research Centre, Dokki, Giza

DOI:

https://doi.org/10.3889/oamjms.2014.101

Keywords:

25-Hydroxy vitamin D, adiponectin, lipid profile, blood pressure, children.

Abstract

BACKGROUND: Association between vitamin D, adiponectin and obesity is a matter of debate, as they play important role in linking obesity with different cardio metabolic risk factors.

AIM: Evaluation of association between metabolic risk factors with both adiponectin and 25-Hydroxy vitamin D [25(OH) D] levels and that between adiponectin and [25(OH) D] among obese Egyptian children.

SUBJECTS AND METHODS: This case-control cross sectional study consisted of 65 obese and 30 healthy children, aged 8-11 years. 25(OH) D, serum adiponectin, total cholesterol, triglycerides, high-density lipoprotein-cholesterol and low-density lipoprotein-cholesterol were measured.

RESULTS: The mean 25(OH)D and adiponectin levels in the obese were lower than that in control group (ð‘ƒ<0.000). 25(OH)D were inversely correlated with body mass index, triglyceride, total cholesterol and LDL-cholesterol. While adiponectin level were inversely correlated with systolic and diastolic blood pressure, and positively correlated with high-density lipoprotein-cholesterol. However, there is no relation between 25(OH) D and adiponectin levels among obese children and total sample.

CONCLUSION: Inspite of strong association between vitamin D and adiponectin levels with metabolic risk factors and obesity, there is no relation between 25(OH)D and adiponectin levels. In obese children, There are significant negative correlations between 25(OH)D with lipid profile, and between adiponectin levels with blood pressure.

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References

James WP. WHO recognition of the global obesity epidemic. Int J Obes (Lond). 2008; 32 Suppl 7: S120-6.

Yach D, Stuckler D, Brownwell KD. Epidemiologic and economic consequences of the global epidemics of obesity and diabetes. Nat Med. 2006;12: 62-66.

Song Q, Sergeev IN. Calcium and vitamin D in obesity. Nutr Res Rev. 2012; 16:1–12.

Nadir MA, Szwejkowski BR, and Witham MD. Vitamin D and cardiovascular prevention. Cardiovascular Therapeutics. 2010; 28(4): e5–e12.

Reis JP, von Muhlen D, Miller III ER, Michos ED, and Appel L J. Vitamin D status and cardiometabolic risk factors in the United States adolescent population. Pediatrics. 2009; 124(3): 371–379.

Walker GE, Ricotti R, Roccio M, Moia S, Bellone S, et al. Pediatric Obesity and Vitamin D Deficiency: A Proteomic Approach Identifies Multimeric Adiponectin as a Key Link between These Conditions. 2014; 9(1): e83685.

Berg AH, Scherer PE. Adipose tissue, inflammation, and cardiovascular disease. Circ Res. 2005; 96:939–949.

Matsuda M, Shimomura I, Sata M et al. Role of adiponectin in preventing vascular stenosis. The missing link of adipovascular axis. Journal of Biological Chemistry. 2002; 277(40): 37487–37491.

Shargorodsky M, Boaz M, Goldberg Y, Matas Z, Gavish D, Fux A, Wolfson N. Adiponectin and vascular properties in obese patients: Is it a novel biomarker of early atherosclerosis? Int J Obes. 2009; 33(5): 553-558.

Hassan NE, El-Masry SA, Al-Tohamy M, El-Batrawy S, Abou-Zeid AW, Anwar M. Adiponectin and Adiposity Indices among Obese Primary School Children .Journal of Applied Sciences Research. 2013; 9(3): 1884-1891.

Kardas F, Kendirci M, Kurtoglu S. Cardiometabolic Risk Factors Related to Vitamin D and Adiponectin in Obese Children and Adolescents. International Journal of Endocrinology. 2013:1-5.

Ghalli I, Salah N, Hussien F, Erfan M, El-Ruby M, Mazen I, Sabry M, Abd El-Razik M, Hossnet S, Ismaail, Abd El-Dyem S. Egyptian growth curves for infants, children and adolescents. Published in: Crecere nel mondo. Satorio A, Buckler JMH and Marazzi N, Ferring Publisher, 2008.

Hiernaux J, Tanner JM. Growth and physical studies. In: Human Biology: guide to field methods. Eds. Weiner J.S., Lourie S.A., IBP. London, Blackwell Scientific Publications. Oxford. UK, 1969.

Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972;18(6):499-502.

Lagunova Z, Porojnicu AC, Vieth R, et al. Serum 25-hydroxyvitamin D is a predictor of serum 1, 25-dihydroxyvitamin D in overweight and obese patients. J Nutr. 2011; 141: 112-7.

Caragheorgheopol A, Gherlan L, Vladoiu S, Alexiu F, Padure A & Sorina. Serum levels of 25(OH)-vitamin D and adipokine’s profile in obese children and adolescents. Endocrine Abstracts. 2013; 32 P811.

Shivaprakash and Joseph. Serum 25-Hydroxy Vitamin D Levels, Plasma Glucose & Lipid Levels. International Journal of Scientific Study. 2014;1(4).

Johnson MD, Nader NS, Weaver AL, Singh R, Kumar S. Relationships between 25 hydroxyvitamin D levels and plasma glucose and lipid levels in pediatric outpatients. J Pediatr. 2010; 156: 444-449.

Cheng S, Massaro JM, Fox CS, et al. Adiposity, cardiometabolic risk, and vitamin D status: the Framingham Heart Study.Diabetes. 2010;59:242–248.

Wortsman J, Matsuoka LY, Chen TC, Lu Z, Holick MF. Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr. 2000; 72: 690–693.

Ross AC, Manson JE, Abrams SA, Aloia JF, Brannon PM, et al. The report on dietary reference intakes for calcium and vitamin D from theInstitute of Medicine: what clinicians need to know. J Clin Endocrinol Metab. 2011; 96:53–58.

Parker-Duffen J, Walsh K..Cardiometabolic effects of adiponectin.2014; 28(1): 81–91.

Franssen R, Monajemi H, Stroes ES, et al. Obesity and dyslipidemia. Med Clin North Am. 2011; 95: 893-902.

Abu Shady MM, Youssef MM, Megahed HS, et al. Association of Serum 25- Hydroxyvitamin D with dyslipidaemia in Egyptian School Children. Australian Journal of Basic and Applied Sciences. 2012; 6(10):541-549.

Dolinsky DH, Armstrong S et al. The Association Between Vitamin D and Cardiometabolic Risk Factors in Children. A Systematic Review. Clinical Pediatrics. 2013; 52: 210-23.

Parikh S, Guo DH, Pollock NK, Petty K, Bhagatwala J et al. Circulating 25-hydroxyvitamin D concentrations are correlated with cardiometabolic risk among American black and white adolescents living in a year-round sunny climate. Diabetes Care. 2012; 35:1133–1138.

Brambilla P, Antolini L, Street ME et al. Adiponectin and hypertension in normal-weight and obese children. American Journal of Hypertension. 2013; 26(2): 257–264.

Li Hy, Chiu YF, Hwu CM, Sheu WH, Hung YJ, Fujimoto W, Quertermous T, Curb JD, Tai TY, Chuang LM. The negative correlation between plasma adiponectin and blood pressure depends on obesity: a family-based association study in SAPPHIRe. Am J Hypertens. 2008;21(4):471-6.

Tamang HK, Timilsina U, Singh KP, Shrestha S, Pandey B, Basnet S, Waiba B, Shrestha U. Assessment of adiponectin level in obese and lean Nepalese population and its possible correlation with lipid profile: A cross-sectional study. Indian J Endocrinol Metab. 2013;17(Suppl 1):S349-54.

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Published

2014-12-15

How to Cite

1.
Hassan NE, El-Masry SA, El Banna RA, Abu Shady MM, Al-Tohamy M, Mouhamed Ali M, Abd El-Moniem MM, Anwar M. 25-Hydroxy Vitamin D, Adiponectin Levels and Cardiometabolic Risk Factors in a Sample of Obese Children. Open Access Maced J Med Sci [Internet]. 2014 Dec. 15 [cited 2021 Jun. 25];2(4):562-6. Available from: https://oamjms.eu/index.php/mjms/article/view/oamjms.2014.101

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Section

A - Basic Science

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