25-Hydroxy Vitamin D, Adiponectin Levels and Cardiometabolic Risk Factors in a Sample of Obese Children
DOI:
https://doi.org/10.3889/oamjms.2014.101Keywords:
25-Hydroxy vitamin D, adiponectin, lipid profile, blood pressure, children.Abstract
BACKGROUND: Association between vitamin D, adiponectin and obesity is a matter of debate, as they play important role in linking obesity with different cardio metabolic risk factors.
AIM: Evaluation of association between metabolic risk factors with both adiponectin and 25-Hydroxy vitamin D [25(OH) D] levels and that between adiponectin and [25(OH) D] among obese Egyptian children.
SUBJECTS AND METHODS: This case-control cross sectional study consisted of 65 obese and 30 healthy children, aged 8-11 years. 25(OH) D, serum adiponectin, total cholesterol, triglycerides, high-density lipoprotein-cholesterol and low-density lipoprotein-cholesterol were measured.
RESULTS: The mean 25(OH)D and adiponectin levels in the obese were lower than that in control group (ð‘ƒ<0.000). 25(OH)D were inversely correlated with body mass index, triglyceride, total cholesterol and LDL-cholesterol. While adiponectin level were inversely correlated with systolic and diastolic blood pressure, and positively correlated with high-density lipoprotein-cholesterol. However, there is no relation between 25(OH) D and adiponectin levels among obese children and total sample.
CONCLUSION: Inspite of strong association between vitamin D and adiponectin levels with metabolic risk factors and obesity, there is no relation between 25(OH)D and adiponectin levels. In obese children, There are significant negative correlations between 25(OH)D with lipid profile, and between adiponectin levels with blood pressure.Downloads
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James WP. WHO recognition of the global obesity epidemic. Int J Obes (Lond). 2008; 32 Suppl 7: S120-6. DOI: https://doi.org/10.1038/ijo.2008.247
Yach D, Stuckler D, Brownwell KD. Epidemiologic and economic consequences of the global epidemics of obesity and diabetes. Nat Med. 2006;12: 62-66. DOI: https://doi.org/10.1038/nm0106-62
Song Q, Sergeev IN. Calcium and vitamin D in obesity. Nutr Res Rev. 2012; 16:1–12. DOI: https://doi.org/10.1017/S0954422412000029
Nadir MA, Szwejkowski BR, and Witham MD. Vitamin D and cardiovascular prevention. Cardiovascular Therapeutics. 2010; 28(4): e5–e12. DOI: https://doi.org/10.1111/j.1755-5922.2010.00192.x
Reis JP, von Muhlen D, Miller III ER, Michos ED, and Appel L J. Vitamin D status and cardiometabolic risk factors in the United States adolescent population. Pediatrics. 2009; 124(3): 371–379. DOI: https://doi.org/10.1542/peds.2009-0213
Walker GE, Ricotti R, Roccio M, Moia S, Bellone S, et al. Pediatric Obesity and Vitamin D Deficiency: A Proteomic Approach Identifies Multimeric Adiponectin as a Key Link between These Conditions. 2014; 9(1): e83685. DOI: https://doi.org/10.1371/journal.pone.0083685
Berg AH, Scherer PE. Adipose tissue, inflammation, and cardiovascular disease. Circ Res. 2005; 96:939–949. DOI: https://doi.org/10.1161/01.RES.0000163635.62927.34
Matsuda M, Shimomura I, Sata M et al. Role of adiponectin in preventing vascular stenosis. The missing link of adipovascular axis. Journal of Biological Chemistry. 2002; 277(40): 37487–37491. DOI: https://doi.org/10.1074/jbc.M206083200
Shargorodsky M, Boaz M, Goldberg Y, Matas Z, Gavish D, Fux A, Wolfson N. Adiponectin and vascular properties in obese patients: Is it a novel biomarker of early atherosclerosis? Int J Obes. 2009; 33(5): 553-558. DOI: https://doi.org/10.1038/ijo.2009.37
Hassan NE, El-Masry SA, Al-Tohamy M, El-Batrawy S, Abou-Zeid AW, Anwar M. Adiponectin and Adiposity Indices among Obese Primary School Children .Journal of Applied Sciences Research. 2013; 9(3): 1884-1891.
Kardas F, Kendirci M, Kurtoglu S. Cardiometabolic Risk Factors Related to Vitamin D and Adiponectin in Obese Children and Adolescents. International Journal of Endocrinology. 2013:1-5. DOI: https://doi.org/10.1155/2013/503270
Ghalli I, Salah N, Hussien F, Erfan M, El-Ruby M, Mazen I, Sabry M, Abd El-Razik M, Hossnet S, Ismaail, Abd El-Dyem S. Egyptian growth curves for infants, children and adolescents. Published in: Crecere nel mondo. Satorio A, Buckler JMH and Marazzi N, Ferring Publisher, 2008.
Hiernaux J, Tanner JM. Growth and physical studies. In: Human Biology: guide to field methods. Eds. Weiner J.S., Lourie S.A., IBP. London, Blackwell Scientific Publications. Oxford. UK, 1969.
Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972;18(6):499-502. DOI: https://doi.org/10.1093/clinchem/18.6.499
Lagunova Z, Porojnicu AC, Vieth R, et al. Serum 25-hydroxyvitamin D is a predictor of serum 1, 25-dihydroxyvitamin D in overweight and obese patients. J Nutr. 2011; 141: 112-7. DOI: https://doi.org/10.3945/jn.109.119495
Caragheorgheopol A, Gherlan L, Vladoiu S, Alexiu F, Padure A & Sorina. Serum levels of 25(OH)-vitamin D and adipokine’s profile in obese children and adolescents. Endocrine Abstracts. 2013; 32 P811. DOI: https://doi.org/10.1530/endoabs.32.P811
Shivaprakash and Joseph. Serum 25-Hydroxy Vitamin D Levels, Plasma Glucose & Lipid Levels. International Journal of Scientific Study. 2014;1(4).
Johnson MD, Nader NS, Weaver AL, Singh R, Kumar S. Relationships between 25 hydroxyvitamin D levels and plasma glucose and lipid levels in pediatric outpatients. J Pediatr. 2010; 156: 444-449. DOI: https://doi.org/10.1016/j.jpeds.2009.09.070
Cheng S, Massaro JM, Fox CS, et al. Adiposity, cardiometabolic risk, and vitamin D status: the Framingham Heart Study.Diabetes. 2010;59:242–248. DOI: https://doi.org/10.2337/db09-1011
Wortsman J, Matsuoka LY, Chen TC, Lu Z, Holick MF. Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr. 2000; 72: 690–693. DOI: https://doi.org/10.1093/ajcn/72.3.690
Ross AC, Manson JE, Abrams SA, Aloia JF, Brannon PM, et al. The report on dietary reference intakes for calcium and vitamin D from theInstitute of Medicine: what clinicians need to know. J Clin Endocrinol Metab. 2011; 96:53–58. DOI: https://doi.org/10.1016/j.jada.2011.01.004
Parker-Duffen J, Walsh K..Cardiometabolic effects of adiponectin.2014; 28(1): 81–91. DOI: https://doi.org/10.1016/j.beem.2013.09.001
Franssen R, Monajemi H, Stroes ES, et al. Obesity and dyslipidemia. Med Clin North Am. 2011; 95: 893-902. DOI: https://doi.org/10.1016/j.mcna.2011.06.003
Abu Shady MM, Youssef MM, Megahed HS, et al. Association of Serum 25- Hydroxyvitamin D with dyslipidaemia in Egyptian School Children. Australian Journal of Basic and Applied Sciences. 2012; 6(10):541-549.
Dolinsky DH, Armstrong S et al. The Association Between Vitamin D and Cardiometabolic Risk Factors in Children. A Systematic Review. Clinical Pediatrics. 2013; 52: 210-23. DOI: https://doi.org/10.1177/0009922812470742
Parikh S, Guo DH, Pollock NK, Petty K, Bhagatwala J et al. Circulating 25-hydroxyvitamin D concentrations are correlated with cardiometabolic risk among American black and white adolescents living in a year-round sunny climate. Diabetes Care. 2012; 35:1133–1138. DOI: https://doi.org/10.2337/dc11-1944
Brambilla P, Antolini L, Street ME et al. Adiponectin and hypertension in normal-weight and obese children. American Journal of Hypertension. 2013; 26(2): 257–264. DOI: https://doi.org/10.1093/ajh/hps033
Li Hy, Chiu YF, Hwu CM, Sheu WH, Hung YJ, Fujimoto W, Quertermous T, Curb JD, Tai TY, Chuang LM. The negative correlation between plasma adiponectin and blood pressure depends on obesity: a family-based association study in SAPPHIRe. Am J Hypertens. 2008;21(4):471-6. DOI: https://doi.org/10.1038/ajh.2008.5
Tamang HK, Timilsina U, Singh KP, Shrestha S, Pandey B, Basnet S, Waiba B, Shrestha U. Assessment of adiponectin level in obese and lean Nepalese population and its possible correlation with lipid profile: A cross-sectional study. Indian J Endocrinol Metab. 2013;17(Suppl 1):S349-54. DOI: https://doi.org/10.4103/2230-8210.119618
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