Prediction of Gut Wall Integrity Loss in Viral Gastroenteritis by Non-Invasive Marker

Authors

  • Hala G. Elnady Child Health Department, National Research Centre, Cairo
  • Lobna S. Sherif Child Health Department, National Research Centre, Cairo
  • Maysa T. Saleh Child Health Department, National Research Centre, Cairo
  • Inas R. El-Alameey Child Health Department, National Research Centre, Cairo
  • Mai M. Youssef Child Health Department, National Research Centre, Cairo
  • Amal I. El Shafie Health Radiation Research Department, National Centre for Radiation Research and Technology, Cairo
  • Iman Helwa Immunogenetics Department, National Research Centre, Cairo
  • Haiam Abdel Raouf Immunogenetics Department, National Research Centre, Cairo
  • Ahmed N. EL-Taweel Environment Virology Laboratory and Water Pollution Department, National Research Centre, Cairo

DOI:

https://doi.org/10.3889/oamjms.2015.023

Keywords:

Viral Gastroenteritis, Gut Wall Integrity Loss, Non Invasive Marker, Predicition

Abstract

BACKGROUND: Intestinal fatty acid binding proteins (I-FABPs) are mainly expressed in the intestinal villi, which are the initial site of destruction in viral gastroenteritis.

AIM: This study was designed to assess serum I-FABPs as a predictor of gut wall integrity loss in viral gastroenteritis.

PATIENTS AND METHODS: This case-control cross-sectional study was conducted on 93 cases of acute viral gastroenteritis. Twenty-eight healthy children matching in age were recruited as control group. Serum I-FABPs were measured using ELISA technique. Viral detection and typing were done by PCR for adenovirus, and by Reverse transcriptase PCR for rotavirus, astrovirus and norovirus.

RESULTS: Serum I-FABPs level was significantly higher in the cases compared to the controls and was also higher in the 46 rotavirus gastroenteritis cases compared to other viral gastroenteritis cases. Serum I- FABPs level was significantly higher in severely dehydrated cases as compared to mildly dehydrated ones (P=0.037).

CONCLUSION: Serum I-FABPs could be used as an early and sensitive predictor marker of gut wall integrity loss in children with viral gastroenteritis and its level can indicate case severity.

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Published

2015-03-05

How to Cite

1.
Elnady HG, Sherif LS, Saleh MT, El-Alameey IR, Youssef MM, El Shafie AI, Helwa I, Raouf HA, EL-Taweel AN. Prediction of Gut Wall Integrity Loss in Viral Gastroenteritis by Non-Invasive Marker. Open Access Maced J Med Sci [Internet]. 2015 Mar. 5 [cited 2024 Apr. 20];3(1):37-45. Available from: https://oamjms.eu/index.php/mjms/article/view/oamjms.2015.023

Issue

Vol. 3 No. 1 (2015): Mar 15 (OAMJMS)

Section

A - Basic Science

License

http://creativecommons.org/licenses/by-nc/4.0

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