Evaluation of Neonatal Hemolytic Jaundice: Clinical and Laboratory Parameters

Authors

  • Anet Papazovska Cherepnalkovski University Pediatric Clinic - Neonatology, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje
  • Vjekoslav Krzelj University Hospital Split and School of Medicine, University of Split, Split
  • Beti Zafirovska-Ivanovska Institute of Epidemiology and Biostatistics, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje
  • Todor Gruev Institute for Clinical Biochemistry, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje
  • Josko Markic University Hospital Split and School of Medicine, University of Split, Split
  • Natasa Aluloska University Pediatric Clinic - Neonatology, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje
  • Nikolina Zdraveska University Pediatric Clinic - Neonatology, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje
  • Katica Piperkovska University Pediatric Clinic - Neonatology, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje

DOI:

https://doi.org/10.3889/oamjms.2015.129

Keywords:

hemolytic jaundice, ABO/Rh isoimmunisation, unspecific etiology, laboratory

Abstract

BACKGROUND: Neonatal jaundice that occurs in ABO or Rhesus issoimunisation has been recognized as one of the major risk factors for development of severe hyperbilirubinemia and bilirubin neurotoxicity.

AIM: Aim of our study was to investigate clinical and laboratory parameters associated with hemolytic jaundice due to Rh and ABO incompatibility and compare results with the group of unspecific jaundice.

MATERIAL AND METHODS: One hundred sixty seven (167) neonatal hyperbilirubinemia cases were included in the study, 24.6% of which presented with ABO/Rhesus type hemolytic jaundice, and the rest with unspecific jaundice. Evaluation included: blood count, reticulocites, serum bilirubin, aminotransferases, blood grouping, and Coombs test, also the day of bilirubin peak, duration of the hyperbilirubinemia, and additional bilirubin measurements.

RESULTS: We showed significantly lower mean values of hemoglobin, erythrocytes and hematocrit and significantly higher values of reticulocytes in the group of ABO/Rh incompatibility compared to the group of jaundice of unspecific etiology; also an earlier presentation and a higher-grade jaundice in this group.

CONCLUSIONS: The laboratory profile in ABO/Rh isoimmunisation cases depicts hemolytic mechanism of jaundice. These cases carry a significant risk for early and severe hyperbilirubinemia and are eligible for neurodevelopmental follow-up. Hematological parameters and blood grouping are simple diagnostic methods that assist the etiological diagnosis of neonatal hyperbilirubinemia.

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Published

2015-12-02

How to Cite

1.
Papazovska Cherepnalkovski A, Krzelj V, Zafirovska-Ivanovska B, Gruev T, Markic J, Aluloska N, Zdraveska N, Piperkovska K. Evaluation of Neonatal Hemolytic Jaundice: Clinical and Laboratory Parameters. Open Access Maced J Med Sci [Internet]. 2015 Dec. 2 [cited 2021 Jun. 25];3(4):694-8. Available from: https://oamjms.eu/index.php/mjms/article/view/oamjms.2015.129

Issue

Section

B - Clinical Sciences

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