Spontaneous Regression of an Incidental Spinal Meningioma

Ali Yilmaz; Zahir Kizilay; Ahmet Sair; Mucahit Avcil; Ayca Ozkul

doi:10.3889/oamjms.2016.005

Authors

Ali Yilmaz Adnan Menderes University, Faculty of Medicine, Neurosurgery Department, Aydin
Zahir Kizilay Adnan Menderes University, Faculty of Medicine, Neurosurgery Department, Aydin
Ahmet Sair Adnan Menderes University, Faculty of Medicine, Neurology Department, Aydin
Mucahit Avcil Adnan Menderes University, Faculty of Medicine, Department of Emergency Medicine, Aydin
Ayca Ozkul Adnan Menderes University, Faculty of Medicine, Neurology Department, Aydin

DOI:

https://doi.org/10.3889/oamjms.2016.005

Keywords:

meningioma, spinal cord, tumour regression

Abstract

AIM: The regression of meningioma has been reported in literature before. In spite of the fact that the regression may be involved by hemorrhage, calcification or some drugs withdrawal, it is rarely observed spontaneously.

CASE REPORT: We report a 17 year old man with a cervical meningioma which was incidentally detected. In his cervical MRI an extradural, cranio-caudal contrast enchanced lesion at C2-C3 levels of the cervical spinal cord was detected. Despite the slight compression towards the spinal cord, he had no symptoms and refused any kind of surgical approach. The meningioma was followed by control MRI and it spontaneously regressed within six months. There were no signs of hemorrhage or calcification.

CONCLUSION: Although it is a rare condition, the clinicians should consider that meningiomas especially incidentally diagnosed may be regressed spontaneously.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Plum Analytics Artifact Widget Block

References

Hallinan JT, Hegde AN, Lim WE. Dilemmas and diagnostic difficulties in meningioma. Clin Radiol. 2013 Aug;68[8]:837-44.

http://dx.doi.org/10.1016/j.crad.2013.03.007 DOI: https://doi.org/10.1016/j.crad.2013.03.007

PMid:23623578

Fathi AR, Roelcke U. Meningioma. Curr Neurol Neurosci Rep. 2013;13(4):337.

http://dx.doi.org/10.1007/s11910-013-0337-4 DOI: https://doi.org/10.1007/s11910-013-0337-4

PMid:23463172

Osborn AG, Salzman KL, Barkovich AJ. Meningioma and atypical and malignant meningioma. In: Osborn AG, editor. Diagnostic imaging: brain. 2nd ed. Salt lake city: Lippincott Williams & Wilkins/Amirys, 2009: p. 72-81.

de Almeida JP, Petteys RJ, Sciubba DM, Gallia GL, Brem H. Regression of intracranial meningioma following intratumoral hemorrhage. J Clin Neurosci. 2009;16:1246 9.

http://dx.doi.org/10.1016/j.jocn.2008.11.017 DOI: https://doi.org/10.1016/j.jocn.2008.11.017

PMid:19560362

Goncalves AM, Page P, Domigo V, Meder JF, Oppenheim C. Abrupt regression of a meningioma after discontinuation of cyproterone treatment. AJNR Am J Neuroradiol. 2010;31:1504 5.

http://dx.doi.org/10.3174/ajnr.A1978 DOI: https://doi.org/10.3174/ajnr.A1978

PMid:20053802

Shimizu J, Matsumoto M, Yamazaki E, Yaesu M. Spontaneous regression of an asymptomatic meningioma associated with discontinuation of progesterone agonist administration. Case report. Neurol Med Chir. 2008;48:227 30.

http://dx.doi.org/10.2176/nmc.48.227 DOI: https://doi.org/10.2176/nmc.48.227

Vadivelu S, Sharer L, Schulder M. Regression of multiple intracranial meningiomas after cessation of long term progesterone agonist therapy. J Neurosurg. 2010;112:920 4.

http://dx.doi.org/10.3171/2009.8.JNS09201 DOI: https://doi.org/10.3171/2009.8.JNS09201

PMid:19731987

Hirota K, Fujita T, Akagawa H, Onda H, Kasuya H. Spontaneous regression together with increased calcification of incidental meningioma. Surg Neurol Int. 2014;5:73.

http://dx.doi.org/10.4103/2152-7806.132957 DOI: https://doi.org/10.4103/2152-7806.132957

PMid:24949216 PMCid:PMC4061579

Ricci SB, Cerchiari U. Spontaneous regression of malignant tumors: Importance of the immune system and other factors [Review]. Oncol Lett 2010;1:941 5. DOI: https://doi.org/10.3892/ol.2010.176

PMid:22870091 PMCid:PMC3412538

Pozzati E, Zucchelli M, Schiavina M, et al. Rapid growth and regression of intracranial meningiomas in lymphangioleiomyomatosis: case report. Surg Neurol. 2007;68:671â€“74.

http://dx.doi.org/10.1016/j.surneu.2006.11.063 DOI: https://doi.org/10.1016/j.surneu.2006.11.063

PMid:17586005

Ahn JY, Lee BH, Cho YJ, et al. Dural arteriovenous ï¬stula associated with meningioma: spontaneous disappearance after tumor removal. Neurol Med Chir [Tokyo]. 2003;43:308â€“11.

http://dx.doi.org/10.2176/nmc.43.308 DOI: https://doi.org/10.2176/nmc.43.308