Role of Cardiac Myocytes Heart Fatty Acid Binding Protein Depletion (H-FABP) in Early Myocardial Infarction in Human Heart (Autopsy Study)

Amany Shabaiek; Nour El-Hoda Ismael; Samar Elsheikh; Hebat Allah Amin

doi:10.3889/oamjms.2016.018

Authors

Amany Shabaiek Egyptian Forensic Medicine Authority, Pathology Department, Cairo
Nour El-Hoda Ismael Faculty of Medicine, Kasr El- Aini, Pathology Department, Cairo
Samar Elsheikh Faculty of Medicine, Kasr El- Aini, Pathology Department, Cairo
Hebat Allah Amin Egyptian Forensic Medicine Authority, Pathology Department, Cairo

DOI:

https://doi.org/10.3889/oamjms.2016.018

Keywords:

detection myocardial infarction, H-FABP, immunohistochemistry, MI, sudden cardiac death

Abstract

BACKGROUND: Many immunohistochemical markers have been used in the postmortem detection of early myocardial infarction.

AIM: In the present study we examined the role of Heart-type fatty acid binding protein (H-FABP), in the detection of early myocardial infarction.

MATERIAL AND METHODS: We obtained samples from 40 human autopsy hearts with/ without histopathological signs of ischemia.

RESULTS: All cases of definite and probable myocardial infarction showed a well-defined area of H-FABP depletion. All of the control cases showed strong H-FABP expression, except two markedly autolysed myocardial samples that showed affected antigenicity.

CONCLUSION: Thus, we suggest H-FABP as being one of the valuable tools facing the problem of postmortem detection of early myocardial infarction/ischemia, but not in autolysis.

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