Clinical Therapeutic Effects of the Application of Doxycycline in the Treatment of Periodontal Disease

Spiro Spasovski; Zlatanka Belazelkoska; Mirjana Popovska; Aneta Atanasovska-Stojanovska; Vera Radojkova-Nikolovska; Ilijana Muratovska; Natasa Toseska-Spasova; Biljana Dzipunova; Bruno Nikolovski

doi:10.3889/oamjms.2016.021

Authors

Spiro Spasovski PHO â€žFjolla Medikaâ€, Skopje
Zlatanka Belazelkoska Faculty of Dentistry, Ss. Cyril and Methodius University of Skopje, 1000 Skopje
Mirjana Popovska Faculty of Dentistry, Ss. Cyril and Methodius University of Skopje, 1000 Skopje
Aneta Atanasovska-Stojanovska Faculty of Dentistry, Ss. Cyril and Methodius University of Skopje, 1000 Skopje
Vera Radojkova-Nikolovska Faculty of Dentistry, Ss. Cyril and Methodius University of Skopje, 1000 Skopje
Ilijana Muratovska Faculty of Dentistry, Ss. Cyril and Methodius University of Skopje, 1000 Skopje
Natasa Toseska-Spasova Faculty of Dentistry, Ss. Cyril and Methodius University of Skopje, 1000 Skopje
Biljana Dzipunova Faculty of Dentistry, Ss. Cyril and Methodius University of Skopje, 1000 Skopje
Bruno Nikolovski PHO ETERNAdent, Skopje

DOI:

https://doi.org/10.3889/oamjms.2016.021

Keywords:

periodontal disease, doxycycline, sub-dose, gingival inflammation, gingival bleeding

Abstract

OBJECTIVE: To compare the therapeutic effects of the application of doxycycline-full dose (100 mg) and sub-dose (20 mg) in the treatment of periodontal disease.

MATERIAL AND METHODS: A total of 60 patients with periodontal disease were examined. Patients are divided into two groups: A) treated with antimicrobial dose of 100 mg doxycycline once daily for 30 days, and B) treated with 2 x 20 mg/day. doxycycline, during 75 days. Among all patients a conservative treatment was carried out and ordinated the proper dose doxycycline in total dose during treatment from 3 gr. Index of dental plaque by LÃ¶e-Sillness, index of gingival inflammation and gingival bleeding by Cowell were followed.

RESULTS: Values of dental plaque in relation first examination, 10th, 20th day, 1 month and 2.5 months, showed that after 2.5 months, average value (x = 0.83) of dental plaque in second group is slightly less than the value (x = 0.93) of dental plaque in the first group. The average value (x = 0.17) of gingival inflammation in second group is significantly less than the value (x = 0.50) of gingival inflammation in the first group. The average value (x = 0.97) of gingival bleeding in patients from the first group was significantly higher than value(x = 0.37) of gingival bleeding in the second group.

CONCLUSION: Patients whose therapy was helped by a sub-dose doxycycline demonstrated positive therapeutic effects on gingival inflammation and bleeding.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Plum Analytics Artifact Widget Block

References

Cobb CM. Clinical significance of non-surgical periodontal therapy: An evidence-based perspective of scaling and root planing. J Clin Periodontol. 2002;29(Suppl.2):6â€“16.

http://dx.doi.org/10.1034/j.1600-051X.29.s2.4.x DOI: https://doi.org/10.1034/j.1600-051X.29.s2.4.x

PMid:12010523

Suvan JE. Effectiveness of mechanical nonsurgical pocket therapy. Periodontol 2000. 2005;37:48â€“71.

http://dx.doi.org/10.1111/j.1600-0757.2004.03794.x DOI: https://doi.org/10.1111/j.1600-0757.2004.03794.x

PMid:15655025

Preshaw PM, Hefti AF, Novak MJ, Michalowicz BS, Pihlstrom BL, Schoor R, et al. Subantimicrobial dose doxycycline enhances the efficacy of scaling and root planing in chronic periodontitis: A multicenter trial. J Periodontol. 2004;75:1068â€“76.

http://dx.doi.org/10.1902/jop.2004.75.8.1068 DOI: https://doi.org/10.1902/jop.2004.75.8.1068

Haffajee AD, Socransky SS, Gunsolley JC. Systemic anti-infective periodontal therapy. A systematic review. Ann Periodontol. 2003;8:115â€“81.

http://dx.doi.org/10.1902/annals.2003.8.1.115 DOI: https://doi.org/10.1902/annals.2003.8.1.115

PMid:14971252

SÃ¡nchez GA, Acquier AB, De Couto A, Busch L, Mendez CF. Association between Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis in subgingival plaque and clinical parameters, in Argentine patients with aggressive periodontitis. Microb Pathog. 2015;82:31-6.

http://dx.doi.org/10.1016/j.micpath.2015.03.016 DOI: https://doi.org/10.1016/j.micpath.2015.03.016

PMid:25812474

Kudalkar MD, Nayak A, Bhat KS, Nayak RN. Effect of Azadirachta indica (Neem) and Aloe vera as compared to subantimicrobial dose doxycycline on matrix metalloproteinases (MMP) -2 and MMP-9: An in-vitro study. Ayu. 2014;35(1):85-9.

http://dx.doi.org/10.4103/0974-8520.141947 DOI: https://doi.org/10.4103/0974-8520.141947

PMid:25364206 PMCid:PMC4213975

Smiley CJ, Tracy SL, Abt E, Michalowicz BS, John MT, Gunsolley J, Cobb CM, Rossmann J, Harrel SK, Forrest JL, Hujoel PP, Noraian KW, Greenwell H, Frantsve-Hawley J, Estrich C, Hanson N. Systematic review and meta-analysis on the nonsurgical treatment of chronic periodontitis by means of scaling and root planing with or without adjuncts. J Am Dent Assoc. 2015;146(7):508-24.

http://dx.doi.org/10.1016/j.adaj.2015.01.028 DOI: https://doi.org/10.1016/j.adaj.2015.01.028

PMid:26113099

Sundararaj SC, Thomas MV, Peyyala R, Dziubla TD, Puleo DA. Design of a multiple drug delivery system directed at periodontitis. Biomaterials. 2013;34(34):8835-42.

http://dx.doi.org/10.1016/j.biomaterials.2013.07.093 DOI: https://doi.org/10.1016/j.biomaterials.2013.07.093

PMid:23948165 PMCid:PMC3773615

Barbato L, Francioni E, Bianchi M, Mascitelli E, Marco LB, Tonelli DP. Clin Cases Miner Bone Metab. Periodontitis and bone metabolism. 2015;12(2):174-177. DOI: https://doi.org/10.11138/ccmbm/2015.12.2.174

Gupta N, Gupta ND, Gupta A, Khan S, Bansal N. Role of salivary matrix metalloproteinase-8 (MMP-8) in chronic periodontitisdiagnosis. Front Med. 2015;9(1):72-6.

http://dx.doi.org/10.1007/s11684-014-0347-x DOI: https://doi.org/10.1007/s11684-014-0347-x

PMid:25098434

Chaturvedi TP, Srivastava R, Srivastava AK, Gupta V, Verma PK. Evaluation of metronidazole nanofibers in patients with chronic periodontitis: A clinical study. Int J Pharma Investig. 2012;2:213â€“217.

http://dx.doi.org/10.4103/2230-973X.107007 DOI: https://doi.org/10.4103/2230-973X.107007

PMid:23580938 PMCid:PMC3618638

Ahuja A, Ali J, Rahman S. Biodegradable periodontal intrapocket device containing metronidazole and amoxycillin: formulation and characterization. Pharmazie. 2006;61:25â€“29.

PMid:16454202

Garrett S, Adams GF, Bogle G, Donly K, Drisko CH, Hallmon WW, et al. The effect of locally delivered controlled release doxycycline or scaling and root planing on periodontal maintenance patients over 9 months. J Periodontol. 2000;71:22-30.

http://dx.doi.org/10.1902/jop.2000.71.1.22 DOI: https://doi.org/10.1902/jop.2000.71.1.22

PMid:10695935

Koromantzos PA, Makrilakis K, Dereka X, Offenbacher S, Katsilambros N, Vrotsos IA, et al. Effect of non-surgical periodontal therapy on C-reactive protein, oxidative stress, and matrix metalloproteinase (MMP)-9 and MMP-2 levels in patients with type 2 diabetes: a randomized controlled study. J Periodontol. 2012;83:3â€“10.

http://dx.doi.org/10.1902/jop.2011.110148 DOI: https://doi.org/10.1902/jop.2011.110148

PMid:21627458

O'Connell PA, Taba M, Nomizo A, Foss Freitas MC, Suaid FA, Uyemura SA, et al. Effects of periodontal therapy on glycemic control and inflammatory markers. J Periodontol. 2008;79:774â€“783.

http://dx.doi.org/10.1902/jop.2008.070250 DOI: https://doi.org/10.1902/jop.2008.070250

PMid:18454655

Llambes F, Silvestre FJ, Hernandez-Mijares A, Guiha R, Caffesse R. Effect of non-surgical periodontal treatment with or without doxycycline on the periodontium of type 1 diabetic patients. J Clin Periodontol. 2005;32:915â€“920.

http://dx.doi.org/10.1111/j.1600-051X.2005.00736.x DOI: https://doi.org/10.1111/j.1600-051X.2005.00736.x

PMid:15998278

Rodrigues DC, Taba MJ, Novaes AB, Souza SL, Grisi MF. Effect of non-surgical periodontal therapy on glycemic control in patients with type 2 diabetes mellitus. J Periodontol. 2003;74:1361â€“1367.

http://dx.doi.org/10.1902/jop.2003.74.9.1361 DOI: https://doi.org/10.1902/jop.2003.74.9.1361

PMid:14584871

Swamy DN, Sanivarapu S, Moogla S, Kapalavai V. Chemically modified tetracyclines: The novel host modulating agents. J Indian Soc Periodontol. 2015;19(4):370-4.

http://dx.doi.org/10.4103/0972-124X.149934

PMid:26392682 PMCid:PMC4555791

Swamy DN, Sanivarapu S, Moogla S, Kapalavai V. Chemically modified tetracyclines: The novel host modulating agents. J Indian Soc Periodontol. 2015;19(4):370-4.

http://dx.doi.org/10.4103/0972-124X.149934 DOI: https://doi.org/10.4103/0972-124X.149934

PMid:26392682 PMCid:PMC4555791

Rohlfing CL, Wiedmeyer HM, Little RR, England JD, Tennill A, Goldstein DE. Defining the relationship between plasma glucose and HbA(1c): analysis of glucose profiles and HbA(1c) in the Diabetes Control and Complications Trial. Diabetes Care. 2002;25:275â€“278.

http://dx.doi.org/10.2337/diacare.25.2.275 DOI: https://doi.org/10.2337/diacare.25.2.275

PMid:11815495

Caton JG, Ciancio SG, Blieden TM, Bradshaw M, Crout RJ, Hefti AF, Massaro JM, Polson AM, Thomas J, Walker C.Treatment with subantimicrobial dose doxycycline improves the efficacy of scaling and root planing in patients with adult periodontitis. J Periodontol. 2000;71(4):521-32.

http://dx.doi.org/10.1902/jop.2000.71.4.521 DOI: https://doi.org/10.1902/jop.2000.71.4.521

PMid:10807113

Mohammad A R, Preshaw PM, Bradshaw MH, Hefti AF, Powala CV, Romanowicz Ðœ. Adjunctive subantimicrobial dose doxycycline in the management of institutionalised geriatric patients with chronic periodontitis. Gerodontology. 2005;22(1):37â€“43.

http://dx.doi.org/10.1111/j.1741-2358.2004.00044.x DOI: https://doi.org/10.1111/j.1741-2358.2004.00044.x

PMid:15747897

Preshaw PM, Novak MJ, Mellonig J. Modifiedrelease subantimicrobial dose doxycycline enhances scaling and root planing in subjects with periodontal disease. Journal of Periodontology. 2008;79(3):440â€“452.

http://dx.doi.org/10.1902/jop.2008.070375 DOI: https://doi.org/10.1902/jop.2008.070375

PMid:18315426

Sgolastra F, Petrucci A, Gatto R, Giannoni M, Monaco A. Long-term efficacy of subantimicrobial-dose doxycycline as an adjunctive treatment to scaling and root planing: a systematic review and meta-analysis. J Periodontol. 2011;82(11):1570-81.

http://dx.doi.org/10.1902/jop.2011.110026 DOI: https://doi.org/10.1902/jop.2011.110026

PMid:21417590

Albandar JM. Adjunctive antibiotics with nonsurgical periodontal therapy improve the clinical outcome of chronic periodontitis in current smokers. J Evid Based Dent Pract. 2012;12(3 Suppl):63-6.

http://dx.doi.org/10.1016/S1532-3382(12)70015-5 DOI: https://doi.org/10.1016/S1532-3382(12)70015-5

Herrera D, Sanz M, Jepsen S, Needleman I, RoldÂ´an S. A systematic review on the effect of systemic antimicrobials as an adjunct to scaling and root planing in periodontitis patients. Journal of Clinical Periodontology, 2002;29(3):136â€“159.

http://dx.doi.org/10.1034/j.1600-051X.29.s3.8.x DOI: https://doi.org/10.1034/j.1600-051X.29.s3.8.x

PMid:12787214

Angaji M, Gelskey S, Nogueira-Filho G, Brothwell D. A systematic review of clinical efficacy of adjunctive antibiotics in the treatment of smokers with periodontitis. J Periodontol. 2010;81(11):1518-28.

http://dx.doi.org/10.1902/jop.2010.100192 DOI: https://doi.org/10.1902/jop.2010.100192

PMid:20583918