Report on von Willebrand Disease in Malaysia
DOI:
https://doi.org/10.3889/oamjms.2016.030Keywords:
von Willebrand Disease, Malaysian report, Sociodemographic details, Laboratory profiles, Year 2011-2013Abstract
BACKGROUND: Von Willebrand disease (vWD) is an inherited hemostatic disorder that affects the hemostasis pathway. The worldwide prevalence of vWD is estimated to be 1% of the general population but only 0.002% in Malaysia.
AIM: Our present paper has been written to disclose the statistical counts on the number of vWD cases reported from 2011 to 2013.
MATERIAL AND METHODS: This article is based on sociodemographic data, diagnoses and laboratory findings of vWD in Malaysia. A total of 92 patients were reported to have vWD in Malaysia from 2011 to 2013.
RESULTS: Sociodemographic-analysis revealed that 60% were females, 63% were of the Malay ethnicity, 41.3% were in the 19-44 year old age group and 15.2% were from Sabah, with the East region having the highest registered number of vWD cases. In Malaysia, most patients are predominately affected by vWD type 1 (77.2%). Factor 8, von Willebrand factor: Antigen and vWF: Collagen-Binding was the strongest determinants in the laboratory profiles of vWD.
CONCLUSION: This report has been done with great interest to provide an immense contribution from Malaysia, by revealing the statistical counts on vWD from 2011-2013.Downloads
Metrics
Plum Analytics Artifact Widget Block
References
Moveforward "Health Care in Malaysia". Expatforum.com. Accessed via: http://en.academic.ru/dic.nsf/enwiki/11562. Accessed on February 25, 2014.
World health ranking website. Accessed via:
http://www.worldlifeexpectancy.com/country-health-profile/malaysia, 2014. Accessed on: March 10, 2014.
Pusat Darah Negara Website, 2012. Accessed via: http://translate.google.com.my/translate?hl=en&sl=ms&u=http://www.pdn.gov.my/&prev=/search%Fq%3Dpusat%2Bdarah%2Bnegara%26biw%3D1024%26bih%3D499. Accessed on March 10, 2014.
Tanushri M. von Willebrand disease: An overview. In book: National Hematology. Chapter: Von Willebrand disease, Publisher: Springer, Editors: Dr MB Agarwal. 2007;131-140.
Goodeve A, Eikenboom J, Castaman G, et al. Phenotype and genotype of a cohort of families historically diagnosed with type 1 von Willebrand disease in the European study, molecular and clinical markers for the diagnosis and management of type 1 von Willebrand disease. (MCMDM-1VWD). Blood. 2007;109:112-121.
http://dx.doi.org/10.1182/blood-2006-05-020784 DOI: https://doi.org/10.1182/blood-2006-05-020784
PMid:16985174
Kwa SB, Chan KY, Chan SK, et al. Haemophilia in Singapore. A study of the clinical and Haematological features in 36 patients. Sing Medic J. 1967;8(1):21-34.
PMid:6044166
Riley RS. von Willebrand Disease. 2005. Accessed via: http://www.pathology.vcu.edu/clinical/coag/vWD.pdf. Accessed on 23th March 2014.
Sadler JE, Budde U, Eikenboom JCJ, et al. Update on the pathophysiology and classification of von Willebrand disease: A report of the subcommittee on von Willebrand factor. J of Thromb & Haemost. 2006;4:2103–2114.
http://dx.doi.org/10.1111/j.1538-7836.2006.02146.x DOI: https://doi.org/10.1111/j.1538-7836.2006.02146.x
PMid:16889557
Practical-Hemostasis, A practical guide to laboratory hemostasis. 2012. Accessed via: http://practical-haemostasis.com/Factor%20Assays/VWF/vwf_assays_introduction.html. Accessed on 23th March 2014.
Branchford BR, Di Paola J. Making a diagnosis of VWD. Hematol Am Soc Hematol educ program. 2012;161-167. DOI: https://doi.org/10.1182/asheducation.V2012.1.161.3798231
The Diagnosis, Evaluation, and Management of von willebrand disease. U.S Department of Health and Human Services. National Institutes of Health. National Heart Lung and Blood Institute. NIH Publication No. 08-5832; 2007.
Laffan M, Brown SA, Collins PW, et al. The diagnosis of von Willebrand disease: a guideline from the UK Haemophilia Centre Doctors Organization. Haemophilia. 2004;10(3):199-217.
http://dx.doi.org/10.1111/j.1365-2516.2004.00894.x DOI: https://doi.org/10.1111/j.1365-2516.2004.00894.x
PMid:15086318
Keeney S, Bowen D, Cumming A, et al. The molecular analysis of von Willebrand disease: a guideline from the UK Haemophilia centre doctors organisation Haemophilia genetics laboratory network. Haemophilia. 2008;14(5):1099-1111.
http://dx.doi.org/10.1111/j.1365-2516.2008.01813.x DOI: https://doi.org/10.1111/j.1365-2516.2008.01813.x
PMid:18637846
Brandt JT. Laboratory Evaluation of Platelet Disorders. In McClatchey, K.D. Clinical Laboratory Medicine, 2nd Ed. Lippincott, Williams, and Wilkins; 2002.
Mohsin S, Aslam M, Hussain S, et al. Clinical manifestations and complications of von Willebrand disease. J Rawalpindi Med College. 2012;6(1):19-21.
Downloads
Published
How to Cite
Issue
Section
License
http://creativecommons.org/licenses/by-nc/4.0