Fibroepithelioma of Pinkus (FeP) Located in the Left Lower Quadrant of the Abdomen - Case Report and Review of the Literature

Mara Madalina Mihai; Cristiana Voicu; Mihai Lupu; Nely Koleva; James W. Patterson; Torello Lotti; Jacopo Lotti; Katlein FranÃ§a; Atanas Batashki; Ilko Bakardzhiev; Uwe Wollina; Georgi Tchernev

doi:10.3889/oamjms.2017.079

Authors

Mara Madalina Mihai Oncologic Dermatology and Allergology Department, â€Carol Davilaâ€ University of Medicine and Pharmacy; 17 Marasti Blvd, Bucharest
Cristiana Voicu Dermatology Department, Polisano Clinic, 26Z Timisoara Blvd, Bucharest
Mihai Lupu Dermatology Department, Medas Medical Centre,41 Nicolae Grigorescu Blvd, Bucharest
Nely Koleva Medical Institute of Ministry of Interior (MVR), Department of Dermatology and Dermatologic Surgery, General Skobelev 79, 1606 Sofia
James W. Patterson University of Virginia Health System, 1215 Lee Street, Box 800214, Charlottesville, VA 22908
Torello Lotti University of Rome â€œG. Marconiâ€, Rome, Italy; Department of Biotechnology, Delft University of Technology, 2628 BC, Delft
Jacopo Lotti Department of Nuclear, Subnuclear and Radiation Physics, University of Rome "G. Marconi", Rome
Katlein FranÃ§a Institute for Bioethics & Health Policy; Department of Dermatology & Cutaneous Surgery; Department of Psychiatry & Behavioral Sciences, University of Miami Miller School of Medicine - Miami, FL
Atanas Batashki Specialist in Abdominal and Thoracic Surgery, Department of special Surgery, Medical University of Plovdiv, bul. "Peshtersko shose" Nr 66, 4000
Ilko Bakardzhiev Medical College, Medical University of Varna, Varna 9000
Uwe Wollina Department of Dermatology and Allergology, Academic Friedrichstrasse 41, 01067, Dresden
Georgi Tchernev Medical Institute of Ministry of Interior (MVR), Department of Dermatology and Dermatologic Surgery, General Skobelev 79, 1606 Sofia, Bulgaria; Onkoderma - Policlinic for Dermatology, Venereology and Dermatologic Surgery, 26 General Skobelev blvd., Sofia

DOI:

https://doi.org/10.3889/oamjms.2017.079

Keywords:

fibroepithelioma of Pinkus, basal cell carcinoma, trichoblastoma, trichoepithelioma

Abstract

BACKGROUND: Fibroepithelioma of Pinkus (FeP) is an uncommon and controversial skin lesion, sharing features of both basal cell carcinoma (BCC) and trichoepithelioma. In this article, we present a case of FeP and synthesise current concepts on the etiopathogenesis, diagnosis and treatment of this uncommon tumour.

CASE REPORT: We report the case of an 88-year-old male patient presenting to the dermatology clinic for a sharply demarcated, pink, exophytic cutaneous tumour situated in the left inguinal region. The histopathological examination performed after complete surgical excision of the lesion revealed a diagnosis of FeP. A systematic review of the literature was conducted. The terms `fibroepithelioma` and `Pinkus` have been searched in bibliographical databases, including PubMed and Google Scholar, without time limitation up to February 15th, 2017. Seventy-nine articles that fulfilled all the required conditions were identified. Relevant citations and additional articles identified from references have been assessed. The systematic review included a total number of 452 cases of FeP.

CONCLUSION: Even though FeP is considered a relatively rare tumour, its true incidence rate might be higher than previously believed.Â The clinical aspects of the lesion described in this paper and its location in the left lower quadrant of the abdomen are classic features of FeP. Histopathologic examination revealed features of both BCC and trichoepithelioma. Further epidemiological studies are required to clarify whether patients with FEP should be screened for the occurrence of other malignancies.

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