Genital Bowenʼs Disease in a Bulgarian Patient: Complete Remission after Surgical Approach

Authors

  • Georgi Tchernev Medical Institute of Ministry of Interior (MVR), Department of Dermatology and Dermatologic Surgery, General Skobelev 79, 1606 Sofia
  • Torello Lotti University of Rome “G. Marconi”, Rome
  • Uwe Wollina Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, Friedrichstrasse 41, 01067 Dresden
  • Serena Gianfaldoni University G. Marconi of Rome, Rome
  • Ilia Lozev Medical Institute of Ministry of Interior, Department of General, Vascular and Abdominal Surgery, General Skobelev 79, 1606 Sofia
  • Jacopo Lotti Department of Nuclear, Subnuclear and Radiation Physics, University of Rome "G. Marconi", Rome
  • Katlein França Institute for Bioethics & Health Policy; Department of Dermatology & Cutaneous Surgery; Department of Psychiatry & Behavioral Sciences, University of Miami Miller School of Medicine - Miami, FL
  • Atanas Batashki Abdominal and Thoracic Surgery, Department of Special Surgery, Medical University of Plovdiv, bul. "Peshtersko shose" Nr 66, 4000 Plovdiv
  • Anastasiya Chokoeva “Onkoderma” - Policlinic for Dermatology and Dermatologic Surgery, General Skobelev 26 blvd., Sofia

DOI:

https://doi.org/10.3889/oamjms.2017.119

Keywords:

bowen, genital located, imiquimod, surgical approach, complete remission

Abstract

A 60-year-old male patient presented with complaints of persistent red to a brown-colored plaque on his scrotum, with duration of approximately three years. The patient had been treated with oral and topical antifungals for inguinal tinea for several months and after that with topical corticosteroids for eczema for several more months. None of the regimens achieved any therapeutic effect. The histopathological evaluation revealed the presence of atypical keratinocytes in all layers of the epidermis with the altered epidermal pattern, spread parabasal mitotic activity, without secondary satellites, multiple dyskeratotic cells and multinucleated cells. The diagnosis of an intraepithelial non-invasive squamous cell carcinoma, associated with koilocytic dysplasia and hyperplasia was made, meeting the criteria for Bowen disease. An elliptic surgical excision of the lesion was made, while the defect was closed with single stitches, with excellent therapeutic and aesthetic result. First described by John T. Bowen in 1912, Bowen disease (BD) represents a squamous cell carcinoma (SCC) in situ with the potential for significant lateral spread. Treatment options include the application of topical 5-flurorouracil cream – useful in non-hairy areas, imiquimod cream or destructive methods such as radiation, curettage, cryotherapy, laser ablation and photodynamic therapy, especially useful in nail bed involvement. Despite the early lesions, surgical excision is the preferred treatment option, regarding the potential malignant transformation risk.

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References

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Published

2017-07-21

How to Cite

1.
Tchernev G, Lotti T, Wollina U, Gianfaldoni S, Lozev I, Lotti J, França K, Batashki A, Chokoeva A. Genital Bowenʼs Disease in a Bulgarian Patient: Complete Remission after Surgical Approach. Open Access Maced J Med Sci [Internet]. 2017 Jul. 21 [cited 2023 Jan. 26];5(4):545-6. Available from: https://oamjms.eu/index.php/mjms/article/view/oamjms.2017.119

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