Pigmented Paraaxillary Located "Complex" Basal Cell Carcinoma Imitating clinically irritated Melanocytic Lesion - Succesfull Surgical Approach in Bulgarian Patient


  • Cristiana Voicu Dermatology Department, Polisano Clinic, 26Z Timisoara Blvd, Bucharest
  • Mara Mihai Oncologic Dermatology and Allergology Department, ”Carol Davila”, University of Medicine and Pharmacy, 17 Marasti Blvd, Bucharest
  • Mihai Lupu Dermatology Department, Medas Medical Centre, 41 Nicolae Grigorescu Blvd, Bucharest
  • James W. Patterson Department of Pathology, University of Virginia Health System, 1215 Lee Street, Box 800214, Charlottesville, VA 22908
  • Nely Koleva Department of Pathology, Medical Institute of Ministry of Interior (MVR), Department of Dermatology and Dermatologic Surgery, General Skobelev 79, 1606 Sofia
  • Uwe Wollina Department of Dermatology and Allergology, Academic Friedrichstrasse 41, 01067, Dresden
  • Torello Lotti Department of Dermatology, University of Rome “G. Marconi”, Rome
  • Jacopo Lotti Department of Nuclear, Subnuclear and Radiation Physics, University of Rome "G. Marconi", Rome
  • Katlein França Institute for Bioethics & Health Policy; Department of Dermatology & Cutaneous Surgery; Department of Psychiatry & Behavioral Sciences, University of Miami Miller School of Medicine - Miami, FL
  • Atanas Batashki Abdominal and Thoracic Surgery, Department of Special Surgery, Medical University of Plovdiv, bul. "Peshtersko shose" Nr 66, 4000 Plovdiv
  • Serena Gianfaldoni University G. Marconi of Rome, Rome
  • Ilko Bakardzhiev Medical College, Medical University of Varna, Varna
  • Hristo Mangarov Medical Institute of Ministry of Interior (MVR), Department of Dermatology and Dermatologic Surgery, General Skobelev 79, 1606 Sofia
  • Georgi Tchernev Medical Institute of Ministry of Interior (MVR), Department of Dermatology and Dermatologic Surgery, General Skobelev 79, 1606 Sofia, Bulgaria; Onkoderma” - Policlinic for Dermatology, Venereology and Dermatologic Surgery, 26 General Skobelev blvd., Sofia




basal cell carcinoma, axillary region, basosquamous carcinoma


BACKGROUND: Basal cell carcinoma (BCC) is the most frequently encountered neoplasm worldwide. While nodular BCC is the most frequent clinical subtype, other forms of BCC, such as superficial, cystic, morpheiform, infiltrative, and pigmented may also be encountered.

CASE PRESENTATION: We present the case of a 67-year-old male with a relatively well-defined infiltrative, pigmented plaque with multiple colours and peripheral growth situated in the right axillary region. The histopathologic examination performed after complete surgical excision of the tumour revealed a complex pigmented BCC with macronodular, fibroepithelioma-like, cystic, focally infiltrative and basosquamous features.

CONCLUSION: Uncommon locations of BCCs in sun-protected areas such as the axillary region require a higher degree of suspicion for diagnosis. The complex histology of the presented case, including subtypes with differing biologic attributes, emphasises the importance of histopathological examination in the diagnosis and therapeutic management of BCC.


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Urbach F. Incidence of non melanoma skin cancer. Dermatol Clin. 1991;9:751–5. PMid:1934649

Dourmishev A, Popova L, Dourmishev L. Basal-cell carcinoma and squamous-cell carcinomas: Epidemiology, location and radiotherapy. Skin Cancer. 1996;11:195–200.

Chung S. Basal Cell Carcinoma. Arch Plast Surg. 2012; 39(2): 166–170. https://doi.org/10.5999/aps.2012.39.2.166 PMid:22783519 PMCid:PMC3385325

Dourmishev LA, Rusinova D, and Botev I. Clinical variants, stages, and management of basal cell carcinoma. Indian Dermatol Online J. 2013; 4(1): 12–17. https://doi.org/10.4103/2229-5178.105456 PMid:23439912 PMCid:PMC3573444

Mulvany NJ, Allen DG. Differentiated intraepithelial neoplasia of the vulva. Int J Gynecol Pathol. 2008;27:125–35. https://doi.org/10.1097/pgp.0b0318134ea34 PMid:18156987

Lo JS, Snow SN, Reizner GT, Mohs FE, Larson PO, Hruza GJ. Metastatic basal cell carcinoma: Report of twelve cases with a review of the literature. J Am Acad Dermatol. 1991;24:715–9. https://doi.org/10.1016/0190-9622(91)70108-E

Dessinioti C, Antoniou C, Katsambas A, Stratigos AJ. Basal cell carcinoma: What's new under the sun. Photochem Photobiol. 2010;86:481–91. https://doi.org/10.1111/j.1751-1097.2010.00735.x PMid:20550646

Cabrera HN, Gómez ML. Skin cancer induced by arsenic in the water. J Cutan Med Surg. 2003;7:106–11. https://doi.org/10.1177/120347540300700202 PMid:12447618

Chan PC, Haseman JK, Boorman GA, Huff J, Manus AG, Cardy RH. Forestomach lesions in rats and mice administered 3-chloro-2-methylpropene by gavage for two years. Cancer Res. 1986;46:6349–52. PMid:3779651

Kubasiewicz M, Starzy-ski Z. Case-referent study on skin cancer and its relation to occupational exposure to polycyclic aromatic hydrocarbons. I. Study design. Pol J Occup Med. 1989;2:221–8. PMid:2489425

Emmert S, Schön MP, Haenssle HA. Molecular biology of basal and squamous cell carcinomas. Adv Exp Med Biol. 2014;810:234-52. https://doi.org/10.1007/978-1-4939-0437-2_13

de Zwaan SE, Haass NK. Genetics of basal cell carcinoma. Australas J Dermatol. 2010;51:81–92. https://doi.org/10.1111/j.1440-0960.2009.00579.x PMid:20546211

Von Hoff DD, LoRusso PM, Rudin CM, et al. Inhibition of the hedgehog pathway in advanced basal-cell carcinoma. N Engl J Med. 2009;361:1164–1172. https://doi.org/10.1056/NEJMoa0905360 PMid:19726763

Saxena K, Manohar V, Bhakhar V, Bahl S. Adenoid basal cell carcinoma: a rare facet of basal cell carcinoma. BMJ Case Rep. 2016;2016:10.

Viera M, Amini S, Huo R, Oliviero M, Bassalo S. A New Look at Fibroepithelioma of Pinkus. Features on Confocal Microscopy. J Clin Aesthet Dermatol. 2008; 1(2): 42–44. PMid:21103323 PMCid:PMC2989825

Aydin D, Rosenkrantz Hölmich L, Jakobsen LP. Metastatic basal cell carcinoma caused by carcinoma misdiagnosed as acne – case report and literature review. Clin Case Rep. 2016; 4(6): 601–604. https://doi.org/10.1002/ccr3.575 PMid:27398205 PMCid:PMC4891487

Lanoue J, Goldenberg G. Basal Cell Carcinoma. A Comprehensive Review of Existing and Emerging Nonsurgical Therapies. J Clin Aesthet Dermatol. 2016; 9(5): 26–36. PMid:27386043 PMCid:PMC4928477

Enachescu CI, Mihai MM. Clinical and histological features of basal cell carcinomas. A five-year experience in a dermatology clinic. Rev Chim. 2016;67(9):1701- 1706.

Cohen PR. Axillary basal cell carcinoma in patients with Goltz-Gorlin syndrome: report of basal cell carcinoma in both axilla of a woman with basal cell nevus syndrome and literature review. Dermatol Online J. 2014;20(8).

Cohen PR. Basal cell carcinoma of the axilla: review of the world literature. Am J Clin Dermatol. 2014;15(2):95-100. https://doi.org/10.1007/s40257-014-0066-8 PMid:24567258

Bajaj S, Sharma PK, Kar HK. Linear adamantinoid basal cell carcinoma in the axilla. Dermatol Online J. 2015;21(5). pii: 13030/qt8k0713nb.

Mohan SV, ChangAL. Advanced Basal Cell Carcinoma: Epidemiology and Therapeutic Innovations. Curr Dermatol Rep. 2014;3:40-45. eCollection 2014.



How to Cite

Voicu C, Mihai M, Lupu M, Patterson JW, Koleva N, Wollina U, Lotti T, Lotti J, França K, Batashki A, Gianfaldoni S, Bakardzhiev I, Mangarov H, Tchernev G. Pigmented Paraaxillary Located "Complex" Basal Cell Carcinoma Imitating clinically irritated Melanocytic Lesion - Succesfull Surgical Approach in Bulgarian Patient. Open Access Maced J Med Sci [Internet]. 2017 Jul. 24 [cited 2024 Apr. 12];5(4):497-500. Available from: https://oamjms.eu/index.php/mjms/article/view/oamjms.2017.141

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