Neglected Under Lip Cancer
Keywords:Lip cancer, Neglected, Chemotherapy, Surgery, Cetuximab
AbstractThe lip represents an anatomical area of the interface between the skin and oral mucosa. It is, therefore, not entirely surprising that SCC of the lip exhibits mixed features between cutaneous and oral mucosal SCC, namely regarding risk factors and biological behaviour. The main risk factors for lip SCC include ultraviolet radiation exposure, low phototype, tobacco and alcohol use, and immunosuppression. Lip SCC usually presents clinically as a nodule or a tumour with a keratotic surface that commonly ulcerates. There is often a background of actinic cheilitis. The particularly exuberant presentation of our case can most probably be explained by the long evolution of a tumour before the patient reached medical attention. Patients with regional lymph node metastasis are usually offered regional lymph node dissection (usually of the neck). Radiotherapy and/or chemotherapy may be used in advanced cases, particularly in unresectable tumours, tumours with high-risk features and metastatic disease. The large size of a tumour in our case, most probably due to its long evolution, highlights the importance of timely diagnosis to avoid such extreme presentations and the consequent need for more aggressive treatment.
Bota JP, Lyons AB, Carroll BT. Squamous cell carcinoma of the lip â€“ a review of squamous cell carcinogenesis of the mucosal and cutaneous junction. Dermatol Surg. 2017; 43: 494-506. https://doi.org/10.1097/DSS.0000000000001020 PMid:28157733
Erisen L, Basut O, Tezel I, et al. Regional epidemiological features of the lip, oral cavity, and oropharyngeal cancer. J Environ Pathol Toxicol Oncol. 1996; 15:225-229. PMid:9216811
Pottegard A, Hallas J, Olesen, et al. Hydrochlorothiazide use is strongly associated with risk of lip cancer. J Intern Med. 2017. https://doi.org/10.1111/joim.12629
Bichakjian CK, Olencki T, Aasi S, Alam M, et al. Squamous cell skin Cancer, version 1. 2015. Clinical practice guidelines in oncology. J Natl Compr Cancer Netw. 2015;13.
Ozturk K, Gode S, Erdogan U, Akyildiz S, Apaydin F. Squamous cell carcinoma of the lip: survival analysis with long-term follow-up. Eur Arch Otorhinolaryngol. 2015; 272(11):3545-50. https://doi.org/10.1007/s00405-014-3415-6 PMid:25467011
Unsal AA, Unsal AB, Henn TE, Baredes S, Eloy JA. Cutaneous squamous cell carcinoma of the lip: a population-based analysis. Laryngoscope. 2017.
How to Cite
All rights reserved.