Sweetâ€™s Syndrome (SS) in the Course of Acute Myeloid Leukaemia (AML)
Keywords:Sweet syndrome, Acute leukaemia, Complete response, Epirubicin
AbstractFirstly described by Robert Douglas Sweet in 1964, febrile neutrophilic dermatosis is a disabling, not only cutaneous disorder, clinically characterised by fever and painful erythematous nodules, with a typical background of neutrophilia. Sweetâ€™s syndrome (SS) is a chronic inflammatory reactive disorder of unknown cause and incompletely established pathogenesis, although an interplay between genetic and environmental factors, including infections, is likely to occur. A significant part of cases has been demonstrated to be linked with malignancies, especially in the hematologic setting. Because of the underlying disease and related therapeutic measures, SS may present atypical clinical course, whereas the response to treatment is strictly dependent on the concurrent hematologic disease. Herein we describe a case of a lady who had a refractory form of SS, resulted in a paraneoplastic cutaneous disease, and AML. Surprisingly, clinical remission of SS followed cytotoxic chemotherapy while hematologic disorder obtained a further complete response.
Sweet RD. An acute febrile neutrophilic dermatosis. Br J Dermatol. 1964; 76:349-56. https://doi.org/10.1111/j.1365-2133.1964.tb14541.x PMid:14201182
Cohen PR, Kurzrock R. Sweet's syndrome and malignancy. Am J Med. 1987; 82:1220-6. https://doi.org/10.1016/0002-9343(87)90229-4
Polimeni G, Cardillo R, Garaffo E, Giardina C, MacrÃ¬ R, Sirna V, Guarneri C, Arcoraci V. Allopurinol-induced Sweet's syndrome. Int J Immunopathol Pharmacol. 2016; 29:329-32. https://doi.org/10.1177/0394632015599705 PMid:26684631
Vaccaro M, Guarneri F, Borgia F, CannavÃ² SP, Benvenga S. Association of lichen sclerosus and autoimmune thyroiditis: possible role of Borrelia burgdorferi? Thyroid. 2002; 12:1147-8. https://doi.org/10.1089/105072502321085261 PMid:12593730
Vaccaro M, Guarneri F, Guarneri C. Molecular mimicry: a true pathogenetic concept for T-cell-mediated autoimmune and reactive skin diseases? J Am Acad Dermatol. 2005; 52(1):E3. https://doi.org/10.1016/j.jaad.2004.05.045 PMid:15627073
Vaccaro M, Guarneri F, Guarneri C, Borgia F, CannavÃ² SP. Sweet's syndrome and erythema nodosum after Klebsiella pneumoniae cystitis. Acta Derm Venereol. 2003; 83:290-1. https://doi.org/10.1080/00015550310016562 PMid:12926802
Kazmi SM, Pemmaraju N, Patel KP, Cohen PR, Daver N, Tran KM, Ravandi F, Duvic M, Garcia-Manero G, Pierce S, Nasha A, Borthakur G, Kantarjian H, Cortes J. Characteristics of Sweet's syndrome in patients with acute myeloid leukaemia. Clin Lymphoma Myeloma Leuk. 2015; 15:358-63. https://doi.org/10.1016/j.clml.2014.12.009 PMid:25630528 PMCid:PMC4457594
Anzalone CL, Cohen PR. Acute febrile neutrophilic dermatosis (Sweet's syndrome). Curr Opin Hematol. 2013; 20:26-35. https://doi.org/10.1097/MOH.0b013e32835ad132 PMid:23207661
Vazquez Garcia J, Almagro Sanchez M, Fonseca Capdevila E. Multiple neutrophilic dermatoses in myelodysplastic synfrome. Clin Exp Dermatol. 2001; 26:398-401. https://doi.org/10.1046/j.1365-2230.2001.00844.x PMid:11488825
Cho KH, Han KH, Kim SW, Youn SW, Youn JI, Kim BK. Neutrophilic dermatoses associated with myeloid malignancy. Clin Exp Dermatol. 1997; 22:269-73. https://doi.org/10.1111/j.1365-2230.1997.tb01093.x PMid:9604452
Kannan R, Dutta TK, Goel A, Garg BR, Venkateswaran S, Ratnakar C. Sweet syndrome in chronic myeloid leukaemia. Postgrad Med J. 1995; 71(836):383. https://doi.org/10.1136/pgmj.71.836.383-a PMid:7644412 PMCid:PMC2398149
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