Locally Advanced Basal Cell Carcinoma with Intraocular Invasion


  • Georgi Tchernev Department of Dermatology, Venereology and Dermatologic Surgery, Medical Institute of Ministry of Interior (MVR-Sofia), General Skobelev 79, 1606 Sofia; Onkoderma - Policlinic for Dermatology, Venereology and Dermatologic Surgery, General Skobelev 26, 1606, Sofia
  • Torello Lotti University G. Marconi of Rome - Dermatology and Venereology, Rome
  • Ilia Lozev Medical Institute of Ministry of Interior Department of General, Vascular and Abdominal Surgery, Sofia
  • Georgi Konstantinov Maximov ”Onkoderma”- Policlinic for Dermatology and Dermatologic Surgery, Sofia
  • Uwe Wollina Städtisches Klinikum Dresden - Department of Dermatology and Allergology, Dresden, Sachsen




basal cell carcinoma, advanced, locally destructive, radiation therapy, surgery, vismodegib


We present a 103 - year - old patient, with duration of complaints of about ten years. The initial complaint had been presented as a small nodule, located on the eyebrow, which subsequently ulcerated and encompassed larger regions of the upper and lower eyelids. For the past three years, the patient also had complaints of a worsening of his vision, without seeking for medical help. Within the dermatological examination, an intraocular and periocular localised tumour was established, characterised by a raised peripheral edge and central ulceration. More careful examination revealed that the bulb was fully consumed. The patient refused further diagnosis and treatment. Advanced basal cell carcinomas with intraocular invasion are rare in general. If the patient refuses surgery, radiotherapy and systemic therapy with modern medications such as Vismodegib or Sonidegib are available as treatment options.


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How to Cite

Tchernev G, Lotti T, Lozev I, Maximov GK, Wollina U. Locally Advanced Basal Cell Carcinoma with Intraocular Invasion. Open Access Maced J Med Sci [Internet]. 2018 Jan. 13 [cited 2022 Oct. 1];6(1):126-7. Available from: https://oamjms.eu/index.php/mjms/article/view/oamjms.2018.012

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