Epidermoid Cysts – A Wide Spectrum of Clinical Presentation and Successful Treatment by Surgery: A Retrospective 10-Year Analysis and Literature Review
DOI:
https://doi.org/10.3889/oamjms.2018.027Keywords:
Epidermoid cysts, Pathogenesis, Skin, Surgery, Gardner syndrome, Lowe syndromeAbstract
Epidermoid cysts are common benign lesions of hair-bearing, and less often glabrous skin. They can also occur in oral mucosa and internal organs. In case of cutaneous lesions, an epidermal punctum is a clinical diagnostic hallmark. The clinical presentation is variable leading to some differential diagnoses. Diagnosis of epidermoid cysts needs histopathological confirmation – not only of the potential of malignant transformation. The treatment of choice is surgery. We report a retrospective analysis of 2159 epidermoid cysts treated surgically. Most of the cases can be performed under local anaesthesia. The complication rate of 2.2% is low. To avoid relapses, the cyst wall has to be removed completely. Rare genetic disorders with multiple cysts are Gardner and Lowe syndrome.Downloads
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Plewig G, Landthaler M, Burgdorf W, Hertl M, Ruzicka T (eds.). Braun-Falco's Dermatologie, Venerologie und Allergologie. 6th edition. Berlin – Heidelberg: Springer, 2012. https://doi.org/10.1007/978-3-642-24163-5
Janarthanam J, Mahadevan S. Epidermoid cyst of submandibular region. J Oral Maxillofac Pathol. 2012; 16(3):435–7. https://doi.org/10.4103/0973-029X.102511 PMid:23248482 PMCid:PMC3519225
Kumar U, Lamba S. Intraosseous epidermal inclusion cyst of the great toe: masquerading as bone tumour. J Clin Diagn Res. 2017; 11(6):EJ01-EJ02. https://doi.org/10.7860/JCDR/2017/29249.10100
Yao PS, Lin ZY, Zheng SF, Lin YX, Yu LH, Jiang CZ, Kang DZ. Coexistence of intracranial epidermoid tumor and multiple cerebral aneurysms: A case report and literature review. Medicine (Baltimore). 2017; 96(5):e6012. https://doi.org/10.1097/MD.0000000000006012 PMid:28151901 PMCid:PMC5293464
Min HJ, Lee JM, Han JK, Kim YJ. Influence factor in thickness of cyst wall of epidermal cysts. J Craniofac Surg. 2017; 28(4):e369-72. https://doi.org/10.1097/SCS.0000000000003687 PMid:28328606
Ramakrishnaiah SB, Rajput SS, Gopinathan NS. Epidermoid cyst of the sole - a case report. J Clin Diagn Res. 2016; 10(11):PD06-PD07. https://doi.org/10.7860/JCDR/2016/23225.8787
Utumi ER, Araujo JP, Pedron IG, Yonezaki F, Machado GG, Rocha AC. Extensive epidermoid cyst of the submental region. Autops Case Rep. 2016; 6(2):51-4. https://doi.org/10.4322/acr.2016.031 PMid:27547744 PMCid:PMC4982785
Nishar CC, Ambulgekar VK, Gujrathi AB, Chavan PT. Unusually giant sublingual epidermoid cyst: a case report. Iran J Otorhinolaryngol. 2016; 28(87):291-6. PMid:27602342 PMCid:PMC4994990
Liau JL, Altamura D, Ratynska M, Verdolini R. Basal cell carcinoma arising from an epidermal cyst: when a cyst is not a cyst. Case Rep Dermatol. 2015; 7(1):75-8. https://doi.org/10.1159/000381393 PMid:26034477 PMCid:PMC4448066
Sze S, Richmond I, Bickers A, Saha A. Squamous cell carcinoma arising from a vulval epidermal cyst. J Obstet Gynaecol Res. 2016; 42(11):1623-6. https://doi.org/10.1111/jog.13091 PMid:27785896
Aljufairi E, Alhilli F. Merkel cell carcinoma arising in an epidermal cyst. Am J Dermatopathol. 2016; [Epub ahead of print].
Choi JE, Kwon IH, Seo SH, Kye YC, Ahn HH. Pathogenesis of plantar epidermal cyst: Three-dimensional reconstruction analysis. Ann Dermatol. 2016; 28(1):133-5. https://doi.org/10.5021/ad.2016.28.1.133 PMid:26848239 PMCid:PMC4737825
Egawa K, Egawa N, Honda Y. Human papillomavirus-associated plantar epidermoid cyst related to epidermoid metaplasia of the eccrine duct epithelium: a combined histological, immunohistochemical, DNA-DNA in situ hybridization and three-dimensional reconstruction analysis. Br J Dermatol. 2005; 152(5):961-7. https://doi.org/10.1111/j.1365-2133.2005.06562.x PMid:15888153
Koh KJ, Park HN, Kim KA. Gardner syndrome associated with multiple osteomas, intestinal polyposis, and epidermoid cysts. Imaging Sci Dent. 2016; 46(4):267-72. https://doi.org/10.5624/isd.2016.46.4.267 PMid:28035305 PMCid:PMC5192025
Ikehara S, Utani A. Multiple protrusive epidermal cysts on the scalp of a Lowe syndrome patient. J Dermatol. 2017; 44(1):105-7. https://doi.org/10.1111/1346-8138.13444 PMid:27178641
Reynolds N, Kenealy J. Use of a carbon dioxide laser in the treatment of multiple epidermoid cysts. Br J Plast Surg. 2002; 55(3):260-1. https://doi.org/10.1054/bjps.2002.3790 PMid:12041985
Feng CJ, Ma H. Treatment of epidermal cysts with erbium: YAG laser fenestration: an alternative to surgical intervention. Ann Plast Surg. 2015; 74(Suppl 2):S89-92. https://doi.org/10.1097/SAP.0000000000000463 PMid:25695444
Calderón-Castrat X, Santos-Durán JC, Román-Curto C, Fernández-López E. Carbon dioxide laser: A therapeutic approach for multiple vulvar epidermoid cysts. Dermatol Surg. 2016; 42(2):264-7. https://doi.org/10.1097/DSS.0000000000000614 PMid:26845541
Wollina U. Erbium-YAG laser therapy – analysis of more than 1,200 treatments. Glob Dermatol. 2016; 3(2):268-72. https://doi.org/10.15761/GOD.1000171
Morritt AN, Tiffin N, Brotherston TM. Squamous cell carcinoma arising in epidermoid cysts: report of four cases and review of the literature. J Plast Reconstr Aesthet Surg. 2012; 65(9):1267-9. https://doi.org/10.1016/j.bjps.2012.02.007 PMid:22364661
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