Giant Pendulous Carcinosarcoma – Squamous Cell Carcinoma-Type - of the Leg – A Case Report and Review of the Literature

Authors

  • Uwe Wollina Stadtisches Klinikum Dresden - Department of Dermatology and Allergology, Dresden, Sachsen
  • Ina Riedel Stadtisches Klinikum Dresden - Institute of Pathology "Georg Schmorl" Dresden, Sachsen
  • Mohammad R. Abushika Stadtisches Klinikum Dresden - Department of Dermatology and Allergology, Dresden, Sachsen
  • Torello Lotti University G. Marconi of Rome - Dermatology and Venereology, Rome
  • Georgi Tchernev Department of Dermatology, Venereology and Dermatologic Surgery, Medical Institute of Ministry of Interior, Sofia; Onkoderma, Policlinic for Dermatology and Dermatologic Surgery, Sofia

DOI:

https://doi.org/10.3889/oamjms.2018.036

Keywords:

Non-melanoma skin cancer, Cutaneous carcinosarcoma, Leg, Histopathology, Surgery

Abstract

Cutaneous carcinosarcoma (CCS) is a rare non-melanoma skin cancer with a biphasic growth pattern. A tumour is composed of epithelial and mesenchymal cells that show clonality. In most cases, CCS develops in the head-and-neck region on the chronic sun-exposed skin of males. Here, we describe an 80-year-old female patient who developed a giant, pendulous CCS on the leg.  A tumour was surgically removed. We found no evidence of metastatic spread.

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References

Clark JJ, Bowen AR, Bowen GM, Hyngstrom JR, Hadley ML, Duffy K, Florell SR, Wada DA. Cutaneous carcinosarcoma: a series of six cases and a review of the literature. J Cutan Pathol. 2017; 44(1):34-44. https://doi.org/10.1111/cup.12843 PMid:27730657

Wollina U, Koch A, Schönlebe J, Tchernev G. Carcinosarcoma of skin (sarcomatoid carcinoma) – a rare non-melanoma skin cancer (Case review). Georgian Med News. 2017; 263:7-10.

Zbacnik AP, Rawal A, Lee B, Werling R, Knapp D, Mesa H. Cutaneous basal cell carcinosarcoma: case report and literature review. J Cutan Pathol. 2015; 42(11):903-10. https://doi.org/10.1111/cup.12578 PMid:26268472

Paniz-Mondolfi A, Singh R, Jour G, Mahmoodi M, Diwan AH, Barkoh BA, Cason R, Huttenbach Y, Benaim G, Galbincea J, Luthra R. Cutaneous carcinosarcoma: further insights into its mutational landscape through massive parallel genome sequencing. Virchows Arch. 2014; 465(3):339-50. https://doi.org/10.1007/s00428-014-1628-0 PMid:25031014

Harms PW, Fullen DR, Patel RM, Chang D, Shalin SC, Ma L, Wood B, Beer TW, Siddiqui J, Carskadon S, Wang M, Palanisamy N, Fisher GJ, Andea A. Cutaneous basal cell carcinosarcomas: evidence of clonality and recurrent chromosomal losses. Hum Pathol. 2015; 46(5):690-7. https://doi.org/10.1016/j.humpath.2015.01.006 PMid:25704628

Dawson EK. Carcino-sarcoma of the skin. J R Coll Surg Edinb. 1972; 17(4):243-6. PMid:5073912

Rouas L, Amrani M, Regragui A, Gamra L, Bellabas MA. Carcinosarcoma of the skin. Ann Dermatol Venereol. 2006; 133(4):362-5. https://doi.org/10.1016/S0151-9638(06)70916-4

Agostini T, Mori A, Leporatti G, Dini M, Franchi A. Cutaneous carcinosarcoma: report of a case with myofibroblastic sarcomatous component. Dermatol Surg. 2008; 34(3):418-22. https://doi.org/10.1097/00042728-200803000-00025

Iakovides J, Delides GS. Carcinosarcomas of the skin--report of two cases. Arch Geschwulstforsch. 1988; 58(6):461-4. PMid:3223796

Terada T. Sarcomatoid carcinoma of the lung presenting as a cutaneous metastasis. J Cutan Pathol. 2010; 37(4):482-5. https://doi.org/10.1111/j.1600-0560.2009.01292.x PMid:19602061

Scatena C, Massi D, Franchi A, De Paoli A, Canzonieri V. Rhabdomyosarcoma of the skin resembling carcinosarcoma: report of a case and literature review. Am J Dermatopathol. 2012; 34(1):e1-6. https://doi.org/10.1097/DAD.0b013e31822381fas PMid:22262364

Ram R, Saadat P, Peng D, Vadmal M. Case report and literature review: primary cutaneous carcinosarcoma. Ann Clin Lab Sci. 2005; 35(2):189-94. PMid:15943184

Wollina U, Langner D, Tchernev G. Mushroom-like skin tumors: report of three cases. Open Access Maced J Med Sci. 2017; 5(4):515-7. https://doi.org/10.3889/oamjms.2017.109 PMid:28785347 PMCid:PMC5535672

Toll A, Masferrer E, Hernández-Ruiz ME, Ferrandiz-Pulido C, Yébenes M, Jaka A, Tuneu A, Jucglà A, Gimeno J, Baró T, Casado B, Gandarillas A, Costa I, Mojal S, Pe-a R, de Herreros AG, García-Patos V, Pujol RM, Hernández-Mu-oz I. Epithelial to mesenchymal transition markers are associated with an increased metastatic risk in primary cutaneous squamous cell carcinomas but are attenuated in lymph node metastases. J Dermatol Sci. 2013; 72(2):93-102. https://doi.org/10.1016/j.jdermsci.2013.07.001 PMid:23928229

Kazantseva IA, Khlebnikova AN, Babaev VR. Immunohistochemical study of primary and recurrent basal cell and metatypical carcinomas of the skin. Am J Dermatopathol. 1996; 18(1):35-42. https://doi.org/10.1097/00000372-199602000-00006 PMid:8721589

Ko CJ, Leffell DJ, McNiff JM. Adenosquamous carcinoma: a report of nine cases with p63 and cytokeratin 5/6 staining. J Cutan Pathol. 2009; 36(4):448-52. https://doi.org/10.1111/j.1600-0560.2008.01083.x PMid:19278431

Misago N, Satoh T, Narisawa Y. Basal cell carcinoma with ductal and glandular differentiation: a clinicopathological and immunohistochemical study of 10 cases. Eur J Dermatol. 2004; 14(6):383-7. PMid:15564201

El Harroudi T, Ech-Charif S, Amrani M, Jalil A. Primary carcinosarcoma of the skin. J Hand Microsurg. 2010; 2(2):79-81. https://doi.org/10.1007/s12593-010-0013-8 PMid:22282673 PMCid:PMC3122707

Dittus C, Fountzilas C, Saha D, Magee A. A rare case of ovarian carcinosarcoma with neuroendocrine differentiation. J Community Support Oncol. 2014; 12(2):71-4. https://doi.org/10.12788/jcso.0018 PMid:24971408

Kimura T, Chino M, Ogasawara N, Nakano T, Izumi S, Takeuchi H. Trousseau's syndrome with brachiocephalic vein thrombosis in a patient with uterine carcinosarcoma. A case report. Angiology. 1999; 50(6):515-8. https://doi.org/10.1177/000331979905000611 PMid:10378829

Syme-Grant J, Syme-Grant NJ, Motta L, Stevenson JH, Evans AT. Are primary cutaneous carcinosarcomas underdiagnosed? Five cases and a review of the literature. J Plast Reconstr Aesthet Surg. 2006; 59(12):1402-8. https://doi.org/10.1016/j.bjps.2005.12.057 PMid:17113530

Tran TA, Muller S, Chaudahri PJ, Carlson JA. Cutaneous carcinosarcoma: adnexal vs. epidermal types define high- and low-risk tumors. Results of a meta-analysis. J Cutan Pathol. 2005; 32(1):2-11. https://doi.org/10.1111/j.0303-6987.2005.00260.x PMid:15660649

Published

2018-01-10

How to Cite

1.
Wollina U, Riedel I, Abushika MR, Lotti T, Tchernev G. Giant Pendulous Carcinosarcoma – Squamous Cell Carcinoma-Type - of the Leg – A Case Report and Review of the Literature. Open Access Maced J Med Sci [Internet]. 2018 Jan. 10 [cited 2024 Apr. 18];6(1):112-4. Available from: https://oamjms.eu/index.php/mjms/article/view/oamjms.2018.036

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