Diffuse Normolipemic Plane Xanthoma (DNPX) of the Neck without Xanthelasma Palpebrum


  • Uwe Wollina Städtisches Klinikum Dresden - Department of Dermatology and Allergology, Dresden, Sachsen
  • Jacqueline Schönlebe Städtisches Klinikum Dresden - Institute of Pathology "Georg Schmorl", Dresden
  • Georgi Georgi Tchernev Department of Dermatology, Venereology and Dermatologic Surgery, Medical Institute of Ministry of Interior, Sofia; Onkoderma, Policlinic for Dermatology and Dermatologic Surgery, Sofia
  • Torello Lotti University G. Marconi of Rome - Dermatology and Venereology, Rome




Diffuse normolipemic plane xanthoma, Non-Langerhans histiocytosis, Histology, Treatment, Xanthelasma palpebrarum


Diffuse normolipemic plane xanthoma (DNPX) is an uncommon subtype of non-Langerhans histiocytosis. DNPX is characterised by xanthelasma palpebrarum, diffuse plane xanthoma of the head, neck, trunk, or extremities, and normal plasma lipid levels. The neck is the most common site. We report about a 62-year-old female Caucasian patient, who developed an asymptomatic fine wrinkling and loose skin on the neck and décolleté about three years ago. The skin colour became yellowish. Xanthelasma was absent. Histopathology of a skin biopsy confirmed the diagnosis of DNPX. The patient had a medical history of chronic myeloblastic leukaemia. No other laboratory abnormalities were found. Laser treatment was offered but opposed by the patient.


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How to Cite

Wollina U, Schönlebe J, Georgi Tchernev G, Lotti T. Diffuse Normolipemic Plane Xanthoma (DNPX) of the Neck without Xanthelasma Palpebrum. Open Access Maced J Med Sci [Internet]. 2018 Jan. 10 [cited 2021 May 15];6(1):123-5. Available from: https://oamjms.eu/index.php/mjms/article/view/oamjms.2018.037

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