Unconventional Treatments for Vitiligo: Are They (Un) Satisfactory?
DOI:
https://doi.org/10.3889/oamjms.2018.038Keywords:
vitiligo, oxidative stress, melanocytes stimulation, repigmentation, uncommon therapies, efficacy, safe-profileAbstract
The authors show a brief overview of the vitiligo’s unconventional therapies. A part for well-documented effectiveness of L-phenylalanine, PGE2 and antioxidant agents in the treatment of vitiligo, for the other therapeutical approaches more investigations are needed.Downloads
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Eken ZE. Antioxidants. Pigmentary Disorders. 2015; 2(163):2376-0427.
Li L, Li L, Wu Y et Al. Triple-combination treatment with oral α-lipoic acid, betamethasone injection, and NB-UVB for non-segmental progressive vitiligo. J Cosmet Laser Ther. 2016; 18(3):182-5. https://doi.org/10.3109/14764172.2015.1114646 PMid:26735264
Dell'Anna ML, Mastrofrancesco A, Sala R et Al. Antioxidants and narrow band-UVB in the treatment of vitiligo: a double-blind placebo controlled trial. Clin Exp Dermatol. 2007; 32(6):631-6. https://doi.org/10.1111/j.1365-2230.2007.02514.x PMid:17953631
Namazi MR, Chee Leok GO. Vitiligo and diet: a theoretical molecular approach with practical implications. Indian J Dermatol Venereol Leprol. 2009; 75(2):116-8. https://doi.org/10.4103/0378-6323.48654
Jeong YM, Choi YG, Kim DS et al. Cytoprotective effect of green tea extract and quercetin against hydrogen peroxide-induced oxidative stress. Arch Pharm Res. 2005; 28:1251-1256. https://doi.org/10.1007/BF02978208 PMid:16350851
Guan C, Xu W, Hong W et al. Quercetin attenuates the effects of H2O2 on endoplasmic reticulum morphology and tyrosinase export from the endoplasmic reticulum in melanocytes. Mol Med Rep. 2015; 11(6):4285-90. https://doi.org/10.3892/mmr.2015.3242 PMid:25625855
Vicentini FT. Quercetin in w/o microemulsion: in vitro and in vivo skin penetration and effiacy against UVB-induced skin capers damages evaluated in vivo. Eur J Pharm Biopharm. 2008; 69:948-957. https://doi.org/10.1016/j.ejpb.2008.01.012 PMid:18304790
Szekeres E, Morvay M. Repigmentation of vitiligo macules treated topically with Efudix cream. Dermatologica. 1985; 171(1):55-9. https://doi.org/10.1159/000249389 PMid:4029463
Tsuji T, Hamada T. Topically administered fluorouracil in vitiligo. Arch Dermatol. 1983; 119(9):722-7. https://doi.org/10.1001/archderm.1983.01650330014006 PMid:6614958
Anbar T, Westerhof W, Abdel-Rahman A et Al. Treatment of periungual vitiligo with erbium-YAG- laser plus 5-flurouracil: a left to right comparative study. J Cosmet Dermatol. 2006; 5(2):135-9. https://doi.org/10.1111/j.1473-2165.2006.00240.x PMid:17173588
Tavares-Bello R.Capecitabine-induced hand-foot syndrome and cutaneous hyperpigmentation in an elderly vitiligo patient. J Eur Acad Dermatol Venereol. 2007; 21(10):1434-5.https://doi.org/10.1111/j.1468-3083.2007.02242.x PMid:17958867
Paravar T, Hymes SR. Longitudinal melanonychia induced by capecitabine. Dermatol Online J. 2009; 15(10):11. PMid:19951629
Schäfer M, Dütsch S, auf dem Keller U, et al. Nrf2 establishes a glutathione-mediated gradient of UVB cytoprotection in the epidermis. Genes Dev. 2010; 24:1045-1058. https://doi.org/10.1101/gad.568810 PMid:20478997 PMCid:PMC2867209
Zhu M, Bowden TG. Molecular mechanisms for UV-B irradiation-induced glutathione depletion in cultured human keratinocytes. Photochem Photobiol. 2004; 80:191-196. https://doi.org/10.1562/2004-02-26-RA-091.1 PMid:15244506
Grainger KM. Pigmentation in Parkinson's disease treated with levodopa. Lancet. 1973; i: 97–8. https://doi.org/10.1016/S0140-6736(73)90490-X
Goolamali SK. Levodopa in vitiligo. Lancet. 1973; 1(7804):675-6. https://doi.org/10.1016/S0140-6736(73)92250-2
Woolfson H, Finn OA. Topical levodopa in vitiligo. Lancet. 1972; 1(7750):598. https://doi.org/10.1016/S0140-6736(72)90398-4
Sabaté M, et al. Vitiligo associated with tolcapone and levodopa in a patient with Parkinson's disease. Ann Pharmacother. 1999; 33:1228–9. https://doi.org/10.1345/aph.19090 PMid:10573327
Goldstein G. Mode of action of levamisole. J Rheumatol Suppl. 1978; 4:143-8. PMid:310464
Pasricha JS, Khera V. Effect of prolonged treatment with levamisole on vitiligo with limited and slow-spreading disease. Int J Dermatol. 1994; 33(8):584-7. https://doi.org/10.1111/j.1365-4362.1994.tb02903.x
Khondker L, Khan SI. Efficacy of levamisole for the treatment of slow spreading vitiligo. Mymensingh Med J. 2013; 22(4):761-6. PMid:24292309
Gerigk M, Bujnicki R, Ganpo-Nkwenkwa E et Al. Process control for enhanced L-phenylalanine production using different recombinant Escherichia coli strains. Biotechnol Bioeng. 2002; 80(7):746-54. https://doi.org/10.1002/bit.10428 PMid:12402320
Schallreuter KU, Zschiesche M, Moore J, et Al. In vivo evidence for compromised phenylalanine metabolism in vitiligo. Biochem Biophys Res Commun. 1998; 243(2):395-9. https://doi.org/10.1006/bbrc.1997.8107 PMid:9480820
Greiner D, Ochsendorf FR, Milbradt R. [Vitiligo therapy with phenylalanine/UV A. Catamnestic studies after five years]. Hautarzt. 1994; 45(7):460-3. https://doi.org/10.1007/s001050050104 PMid:7928339
de Leeuw J, van der Beek N, Maierhofer G, et Al. A case study to evaluate the treatment of vitiligo with khellin encapsulated in L-phenylalanin stabilized phosphatidylcholine liposomes in combination with ultraviolet light therapy. Eur J Dermatol. 2003; 13(5):474-7. PMid:14693493
Antoniou C, Schulpis H, Michas T, et Al. Vitiligo therapy with oral and topical phenylalanine with UVA exposure. Int J Dermatol. 1989; 28(8):545-7. https://doi.org/10.1111/j.1365-4362.1989.tb04613.x PMid:2583897
Camacho F, Mazuecos J. Oral and topical L-phenylalanine, clobetasol propionate, and UVA/sunlight--a new study for the treatment of vitiligo. J Drugs Dermatol. 2002; 1(2):127-31. PMid:12847735
Lotti T, Buggiani G, Troiano M, et Al. Targeted and combination treatments for vitiligo. Comparative evaluation of different current modalities in 458 subjects. Dermatol Ther. 2008; 21(Suppl 1):S20-6. https://doi.org/10.1111/j.1529-8019.2008.00198.x PMid:18727812
Buggiani G, Tsampau D, Hercogovà J, et Al. Clinical efficacy of a novel topical formulation for vitiligo: compared evaluation of different treatment modalities in 149 patients. Dermatol Ther. 2012; 25(5):472-6. https://doi.org/10.1111/j.1529-8019.2012.01484.x PMid:23046028
Nordlund JJ, Halder R. Melagenina. An analysis of published and other available data. Dermatologica. 1990; 181(1):1-4. https://doi.org/10.1159/000247848 PMid:2394297
Zhao D, Li Y, Wang P et Al. Melagenine modulates proliferation and differentiation of melanoblasts. Int J Mol Med. 2008; 22(2):193-7. PMid:18636173
Xu AE, Wei XD. Topical melagenine for repigmentation in twenty-two child patients with vitiligo on the scalp. Chin Med J (Engl). 2004; 117(2):199-201.
Miyares CM, Hollands Barca I, Miyares Diaz E et Al. Effectiveness of human placental extract with calcium (Melagenina Plus) for the treatment of vitiligo. Medicina cutánea ibero-latino-americana. 2009; 37(5):207-212.
Bagherani N, Yaghoobi R, Omidian M. Hypothesis: zinc can be effective in treatment of vitiligo. Indian J Dermatol. 2011; 56(5):480-4. https://doi.org/10.4103/0019-5154.87116 PMid:22121258 PMCid:PMC3221203
Yaghoobi et al. Comparison of therapeutic efficacy of topical corticosteroid and oral zinc sulfate-topical corticosteroid combination in the treatment of vitiligo patients: a clinical trial. BMC Dermatology. 2011; 11 :7. https://doi.org/10.1186/1471-5945-11-7 PMid:21453467 PMCid:PMC3079655
Varothai S Bergfeld WF. Androgenetic alopecia: an evidence-based treatment update. American journal of clinical dermatology. 2014; 15 (3): 217–30. https://doi.org/10.1007/s40257-014-0077-5 PMid:24848508
Srinivas CR, Shenoi SD, Balachandran C. Acceleration of repigmentation in vitiligo by topical minoxidil in patients on photochemotherapy. Int J Dermatol. 1990;29(2):154-5. https://doi.org/10.1111/j.1365-4362.1990.tb04096.x PMid:2323875
Malakar S, Dhar S. Leucoderma Associated with the Use of Topical Minoxidil: A Report of Two Cases. Dermatology. 2000; 201:183-184. https://doi.org/10.1159/000018450 PMid:11053933
Jalel A, Soumaya GS, Hamdaoui MH. Vitiligo treatment with vitamins, minerals and polyphenol supplementation. Indian J Dermatol. 2009; 54(4):357-60. https://doi.org/10.4103/0019-5154.57613 PMid:20101338 PMCid:PMC2807713
Tsiskarishvili NI, Katsitadze A, Tsiskarishvili NV et Al. [Efficacy of combined use of antioxidative and phototherapy in the treatment of vitiligo]. Georgian Med News. 2016;52-57. PMid:28009316
Grimes PE, Nashawati R. The Role of Diet and Supplements in Vitiligo Management. Dermatol Clin. 2017; 35(2):235-243. https://doi.org/10.1016/j.det.2016.11.012 PMid:28317532
Kotwal S, Jun M, Sullivan D, et Al. Omega-3 Fatty Acids and Cardiovascular Outcomes: Systematic Review and Meta-Analysis. Circ Cardiovasc Qual Outcomes. 2012; 5(6):808–18. https://doi.org/10.1161/CIRCOUTCOMES.112.966168 PMid:23110790
Miles EA, Calder PC. Influence of marine n-3 polyunsaturated fatty acids on immune function and a systematic review of their effects on clinical outcomes in rheumatoid arthritis. The British journal of nutrition. 2012; 107(Suppl 2) (S2): S171–84.
Kapoor R, Phiske MM, Jerajani HR. Evaluation of safety and efficacy of topical prostaglandin E2 in treatment of vitiligo. Br J Dermatol. 2009;160(4):861-3. https://doi.org/10.1111/j.1365-2133.2008.08923.x PMid:19014395
Parsad D, Pandhi R, Dogra S et Al. Topical prostaglandin analog (PGE2) in vitiligo--a preliminary study. Int J Dermatol. 2002; 41(12):942-5. https://doi.org/10.1046/j.1365-4362.2002.01612.x PMid:12492997
Lotti T, Berti S, Moretti S. Vitiligo therapy. Expert Opin Pharmacother. 2009; 10(17):2779-85. https://doi.org/10.1517/14656560903357509 PMid:19929701
Grimes PE. Bimatoprost 0.03% Solution for the Treatment of Nonfacial Vitiligo. J Drugs Dermatol. 2016; 15(6):703-10. PMid:27272076
Schallreuter KU, Moore J, Behrens-Williams S, Panske A, Harari M. Rapid initiation of repigmentation in vitiligo with Dead Sea climatotherapy in combination with pseudocatalase (PC- KUS). Int J Dermatol. 2002; 41(8):482-7. https://doi.org/10.1046/j.1365-4362.2002.01463.x PMid:12207762
Schallreuter KU, Salem MA, Holtz S et Al. Basic evidence for epidermal H2O2/ONOO(-)-mediated oxidation/nitration in segmental vitiligo is supported by repigmentation of skin and eyelashes after reduction of epidermal H2O2 with topical NB-UVB-activated pseudocatalase PC-KUS. FASEB J. 2013; 27(8):3113-22. https://doi.org/10.1096/fj.12-226779 PMid:23629861
Bakis-Petsoglou S, Le Guay JL, Wittal R. A randomized, double-blinded, placebo-controlled trial of pseudocatalase cream and narrowband ultraviolet B in the treatment of vitiligo. Br J Dermatol. 2009; 161(4):910-7. https://doi.org/10.1111/j.1365-2133.2009.09252.x PMid:19523170
Patel DC, Evans AV, Hawk JL. Topical pseudocatalase mousse and narrowband UVB phototherapy is not effective for vitiligo: an open, single-centre study. Clin Exp Dermatol. 2002; 27(8):641-4. https://doi.org/10.1046/j.1365-2230.2002.01142.x PMid:12472535
Becatti M, Fiorillo C, Barygina V et Al. SIRT1 regulates MAPK pathways in vitiligo skin: insight into the molecular pathways of cell survival. J Cell Mol Med. 2014. https://doi.org/10.1111/jcmm.12206 PMid:24410795 PMCid:PMC3955157
Doppalapudi S, Mahira S, Khan W. Development and in vitro assessment of psoralen and resveratrol co-loaded ultradeformable liposomes for the treatment of vitiligo. J Photochem Photobiol B. 2017; 174:44-57. https://doi.org/10.1016/j.jphotobiol.2017.07.007 PMid:28753523
Wei H. Isoflvone genistein: photoprotection and clinical implications in dermatology. J Nutr. 2003; 133:3811S-3819S. PMid:14608119
Leong LY. How I use coal tar in dermatology. Singapore Med J. 1990; 31(6):614-5. PMid:2281360
Jalel A, Soumaya GS, Hamdaoui MH. Vitiligo treatment with vitamins, minerals and polyphenol supplementation. Indian J Dermatol. 2009; 54(4): 357–360. https://doi.org/10.4103/0019-5154.57613 PMid:20101338 PMCid:PMC2807713
Eberlein-Konig B. Protective effect against sunburn of combined systemic ascorbic acid (vitamin C) and d-alpha tocopherol (vitamin E). J Am Acad Dermatol 1998; 38:45-48. https://doi.org/10.1016/S0190-9622(98)70537-7
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