A â€œYellow Submarineâ€ in Dermoscopy
Keywords:histiocytic sarcoma, dermoscopy, yellow colour, CD68, WHO classification lymphomas
BACKGROUND: Histiocytic sarcoma (HS) is an extremely rare, non-Langerhans cell tumor. HS affects especially adults, its etiology is unknown yet. Skin could be interested by papules or nodules, single or multiple.Â Â
CASE REPORT: A Caucasian man in his late 40s came to our clinic for a naevi evaluation. During the visit, a rose papulonodular lesion was observed in the lumbar region. This lesion was completely asymptomatic, and it had been there for an indefinite period. The clinical evaluation revealed that the lesion appeared elevated, of 9 x 15 mm in dimension, symmetrical and of a homogeneous pinkish colour. The videodermoscopical evaluation revealed a homogeneous yellow central pattern, polymorphic vessels, an eccentric peripheral pigmentation and a white collar. An excisional biopsy was performed. The morphology and the expression of CD163, CD68 and/or lysozyme to the immunophenotypic analysis, revealed the true nature of the lesion.CONCLUSION: HS is usually diagnosed at an already advanced clinical stage and it has a high mortality rate even today. Dermoscopy, showing a yellow and distributed homogeneously colour, can facilitate its hard diagnosis.
Plum Analytics Artifact Widget Block
Takahashi E, Nakamura S. Histiocytic Sarcoma: An Updated Literature Review Based on 2008 WHO classification. J Clin Exp Hematop. 2013; 53(1). https://doi.org/10.3960/jslrt.53.1
Ansari J, Nagash AR, Munker R, et al. Histiocytic sarcoma as a secondary malignancy: photobiology, diagnosis, and treatment. Eur J Haematol. 2016; 97(1): 9-â€16. https://doi.org/10.1111/ejh.12755 PMid:26990812
Swerdlow SH, Campo E, Harris NL, et al. WHO Classification of Tumours of the Haematopoietic and Lymphoid Tissues. IARC. 2008; 4.:270-â€319.
Swerdlow SH, Campo E, Pileri SA, et al. The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood. 2016; 127:2375-â€2390. https://doi.org/10.1182/blood-2016-01-643569 PMid:26980727 PMCid:PMC4874220
Cavicchini S, Tourlaki A, Bottini, et al. Dermoscopy of Solitary Yellow Lesions in Adults. Arch Dermatol. 2008; 144(10):1412. https://doi.org/10.1001/archderm.144.10.1412 PMid:18936419
Argenziano G, Zalaudek I, Corona R, et al. Vascular structures in skin tumours: a dermoscopy study. Arch Dermatol. 2004; 140(12):1485-â€9. https://doi.org/10.1001/archderm.140.12.1485 PMid:15611426
Hornick JL, Jaffe ES, Fletcher CD. Extranodal histiocytic sarcoma: clinicopathologic analysis of 14 cases of a rare epithelioid malignancy. Am J Surg Pathol. 2004; 28:1133â€“1144. https://doi.org/10.1097/01.pas.0000131541.95394.23 PMid:15316312
Escandell I, Ramon MD, Sanchez S, et al. Dermoscopic characteristics of a cutaneous histiocytic sarcoma in a young patient. J Am Acad Dermatol. 2017; 76(2S1): S5-Â¬â€S7.
Garbe C, Peris K, Hauschild A, et al. Diagnosis and treatment of melanoma. European consensus -â€based interdisciplinary guideline-â€ Update 2016. Eur J Cancer. 2016; 63: 201-â€17. https://doi.org/10.1016/j.ejca.2016.05.005 PMid:27367293
How to Cite