Vitiligo in Children: A Review of Conventional Treatments

Serena Gianfaldoni; Uwe Wollina; Georgi Tchernev; Jacopo Lotti; Katlein FranÃ§a; Torello Lotti

doi:10.3889/oamjms.2018.054

Authors

Serena Gianfaldoni University G. Marconi of Rome - Dermatology and Venereology, University G. Marconi of Rome, Rome
Uwe Wollina StÃ¤dtisches Klinikum Dresden, Department of Dermatology and Allergology, 01067 Dresden
Georgi Tchernev Medical Institute of Ministry of Interior Department of General, Vascular and Abdominal Surgery, Sofia
Jacopo Lotti University G. Marconi of Rome - Dept. of Nuclear, Subnuclear and Radiation Physics, Rome
Katlein FranÃ§a University of Miami School of Medicine Ringgold standard institution, Miami, Florida
Torello Lotti University G. Marconi of Rome, Dermatology and Venereology, Rome

DOI:

https://doi.org/10.3889/oamjms.2018.054

Keywords:

Childhood vitiligo, Conventional treatments, Topical treatments, Systemic treatments, Phototherapy, Combined treatments, Surgical therapies

Abstract

Vitiligo is an important skin disease of childhood, which may lead to deep psychological trauma, resulting in a poor quality of life and low self-esteem. The Authors discuss a short review of the more conventional therapies available for the treatment of vitiligo in children.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Plum Analytics Artifact Widget Block

References

Abdel-Naser MB, KrÃ¼ger-Krasagakes S, Krasagakis K et Al. Further evidence for the involvement of both cell-mediated and humoral immunity in generalized vitiligo. Pigment Cell Res. 1994; 7(1):1- 8. https://doi.org/10.1111/j.1600-0749.1994.tb00013.x PMid:8072943

Halder RM, Grimes PE, Cowan CA, et Al. Childhood vitiligo. J Am Acad Dermatol. 1987; 16:948â€“ 54. https://doi.org/10.1016/S0190-9622(87)70119-4

Manzoni AP, Weber MB, Nagatomi AR et Al. Assessing depression and anxiety in the caregivers of pediatric patients with chronic skin disorders. An Bras Dermatol. 2013; 88(6):894-9. https://doi.org/10.1590/abd1806-4841.20131915 PMid:24474096 PMCid:PMC3900338

Tamesis ME, Morelli JG. Vitiligo treatment in childhood: A state of the art review. Paediatr Dermatol. 2010; 27:437â€“45. https://doi.org/10.1111/j.1525-1470.2010.01159.x PMid:20553403

Cho S, Kang HC, Hahm JH. Characteristics of vitiligo in Korean children. Pediatr Dermatol. 2000;17:189-93. https://doi.org/10.1046/j.1525-1470.2000.01749.x PMid:10886749

Amrinder Jit Kanwar, M Sendhil Kumaran. Childhood Vitiligo: Treatment Paradigms. Indian J Dermatol. 2012; 57(6): 466â€“474. https://doi.org/10.4103/0019-5154.103067 PMid:23248365 PMCid:PMC3519254

Gianfaldoni S, Hercogova J, Lotti T. The last frontier of Vitiligo repigmentation. The Asthetic J. 2014; 2014:34-37.

Pascual JC, Fleisher AB. Tacrolimus ointment (Protopic) for atopic dermatitis. Skin Therapy Lett. 2004; 9:1â€“5. PMid:15550992

Lepe V, Moncada B, Castanedo-Cazares JP, et al. A double-blind randomized trial of 0.1% tacrolimus vs 0.05% clobetasol for the treatment of childhood vitiligo. Arch Dermatol. 2003; 139:581 â€“585. https://doi.org/10.1001/archderm.139.5.581 PMid:12756094

KÃ¶se O, Arca E, Kurumlu Z. Mometasone cream versus pimecrolimus cream for the treatment of childhood localized vitiligo. J Dermatolog Treat. 2010; 21:133-9. https://doi.org/10.3109/09546630903266761 PMid:20394489

Sarma N, Singh AK. Topical calcipotriol in childhood vitiligo: An Indian experience. Int J Dermatol. 2004; 43:856â€“9. https://doi.org/10.1111/j.1365-4632.2004.02344.x PMid:15533076

Sarma N. Topical calcipotriol in childhood vitiligo: an Indian experience. Int J Dermatol. 2004; 43:856-9. https://doi.org/10.1111/j.1365-4632.2004.02344.x PMid:15533076

Banerjee K, Barbhuiya JN, Ghosh AP et al. The efficacy of low-dose oral corticosteroids in the treatment of vitiligo patient. Indian J Dermatol Venereol Leprol. 2003; 69:135â€“7. PMid:17642858

Radakovic-Fijan S, Furnsinn-Friedl AM, Honigsmann H, et Al. Oral dexamethasone pulse treatment of vitiligo. J Am Acad Dematol. 2001; 44:814â€“7. https://doi.org/10.1067/mjd.2001.113475 PMid:11312430

Pasricha JS, Khaitan BK. Oral mini-pulse therapy with betamethasone in vitiligo patients having extensive or fast-spreading disease. Int J Dermatol. 1993; 32:753â€“7. https://doi.org/10.1111/j.1365-4362.1993.tb02754.x

Gianfaldoni S, Zarrab Z and Lotti T. Phototherapy and Vitiligo Re-pigmentation: From PUVA to Micro-focused Phototherapy. Journal of Pigmentary Disorders. 2014; 1:102.

Singh S, Khandpur S, Sharma VK, et al. comparison of efficacy and side effect profile of oral PUVA vs. oral PUVA sol in the treatment of vitiligo: a 36 week prospective study. J Eur Acad Dermatol Venereol. 2013; 27(11):1344-51. https://doi.org/10.1111/jdv.12002 PMid:23066663

Kappes UP, Barta U, Merkel U et al. High plasma levels of 8-methoxypsoralen following bath water delivery in dermatological patients. Skin Pharmacol Appl Skin Physiol. 2003; 16(5):305-12. https://doi.org/10.1159/000072070 PMid:12907835

Mai DW, Omohundro C, Dijkstra JW, Bailin PL. Childhood vitiligo successfully treated with bath PUVA. Pediatr Dermatol. 1998; 15(1):53-5. https://doi.org/10.1046/j.1525-1470.1998.1998015053.x PMid:9496807

Scherschun L, Kim JJ, Lim HW. Narrow-band ultraviolet B is a useful and well-tolerate treatment for vitiligo. J Am Acad Dermatol. 2001; 44(6):999-1003. https://doi.org/10.1067/mjd.2001.114752 PMid:11369913

Travis LB, Silverberg NB. Calcipotriene and corticosteroid combination therapy for vitiligo. Pediatr Dermatol. 2004; 21:495-8. https://doi.org/10.1111/j.0736-8046.2004.21418.x PMid:15283800

Majid I, Masood Q, Hassan I, et al. Childhood vitiligo: Response to methylprednisolone oral minipulse therapy and topical fluticasone combination. Indian J Dermatol. 2009; 54:124-7. https://doi.org/10.4103/0019-5154.53185 PMid:20101306 PMCid:PMC2807150

Rath N, Kar HK, Sabhnani S. An open labeled, comparative clinical study on efficacy and tolerability of oral minipulse of steroid (OMP) alone, OMP with PUVA and broad / narrow band UVB phototherapy in progressive vitiligo. Indian J Dermatol Venereol Leprol. 2008; 74:357-60. https://doi.org/10.4103/0378-6323.42905

PMid:18797057

Schallreuter KU, KrÃ¼ger C, WÃ¼rfel BA, et al. From basic research to the bedside: Efficacy of topical treatment with pseudocatalase PC-KUS in 71 children with vitiligo. Int J Dermatol. 2008; 47:743â€“53. https://doi.org/10.1111/j.1365-4632.2008.03660.x PMid:18613887

Tedeschi A, Dall'Oglio F, Micali G, et al. Corrective camouflage in pediatric dermatology. Cutis. 2007; 79:110â€“2. PMid:17388210

Paller AS, Mancini AJ. Disorders of pigmentation. In: Paller AS, Mancini AJ, editors. Hurwitz clinical pediatric dermatology. 3 rd ed. Philadelphia: Elsevier Saunders, 2006: 265-305.

Schwartz R, Sepulveda JE, Quintana T. Possible role of psychological and environmental factors in the genesis of childhood vitiligo. Rev Med Chil. 2009; 137:53â€“62. PMid:19399322

Gupta S, Kumar B. Epidermal grafting for vitiligo in adolescents. Pediatr Dermatol. 2002;19:159- 62. https://doi.org/10.1046/j.1525-1470.2002.00035.x PMid:11994184

Ashique KT, Kaliyadan F. Long-Term Follow-up and Donor Site Changes Evaluation in Suction Blister Epidermal Grafting Done for Stable Vitiligo: A Retrospective Study. Indian J Dermatol. 2015; 60(4):369-72. https://doi.org/10.4103/0019-5154.160482 PMid:26288405 PMCid:PMC4533535

Farajzadeh S, Daraei Z, Esfandiarpour I, Hosseini SH. The efficacy of pimecrolimus 1% cream combined with microdermabrasion in the treatment of non-segmental childhood vitiligo: A randomized placebo-controlled study. Pediatr Dermatol. 2009; 26:286-91. https://doi.org/10.1111/j.1525-1470.2009.00926.x

PMid:19706089