Is There a Place for Local Natural Treatment of Psoriasis?
Keywords:Apitherapy, Psoriasis, Skin disease, Natural therapy, Propolis, Aloe vera
BACKGROUND: Apitherapy is the medical use of honey bee products (honey, propolis, royal jelly, bee wax, and bee venom) to relieve human ailments, propolis in particularly, rich in essential oils such as flavonoid. Propolis is derived from tree buds and plants. It is considered as one of the most well-documented products from the honeybee and has always played an important role in traditional folk medicine. Another renowned plant is Aloe vera appertaining to the Liliaceae family. Its mucilaginous gel has been extensively used in many cultures for its apparent effectiveness in treating wounds, burns, itchiness and hair loss.
AIM: The aim was to assess the efficacy of a mixture in an ointment form of propolis (50%) and aloe vera (3%), in the treatment of mild to moderate psoriasis.
METHODS: In this double-blind control study, 2248 patients with both mild to moderate cases of psoriasis were evaluated from 2012 to 2015.
RESULTS: In Group 1 the overall response at the end of 12 weeks was as follows: Cleared in 64.4% (excellent response), good response in 22.2%, and weak response in 5.6% and no response in 7.7%. In Group 2 (placebo group) no significant improvement was observed after 12 weeks of treatment. Also, histology also demonstrated a marked reduction in hyperkeratosis and acanthosis.CONCLUSION: In comparison with Group 2 (placebo group) patients in Group 1, treated with a mixture of propolis (50%) and aloe vera (3%), in the form of an ointment have shown noteworthy improvement thus substantiating the therapeutic value of propolis and aloe vera in the treatment of mild to moderate psoriasis.
Plum Analytics Artifact Widget Block
Barygina V, Becatti M, Lotti T, Taddei N, Fiorillo C. Low dose cytokines reduce oxidative stress in primary lesional fibroblasts obtained from psoriatic patients. Dermatol Sci. 2016; 83(3):242-4. https://doi.org/10.1016/j.jdermsci.2016.06.002 PMid:27317477
Barygina V, Becatti M, Soldi G, Prignano F, Lotti T, Nassi P, Wright D, Taddei N, Fiorillo C. Altered redox status in the blood of psoriatic patients: involvement of NADPH oxidase and role of anti-TNF-Î± therapy. Redox Rep. 2013; 18(3):100-6. https://doi.org/10.1179/1351000213Y.0000000045 PMid:23601139
Capella GL, Finzi AF. Complementary therapy for psoriasis. Dermatol Ther. 2003; 16(2):164-74. https://doi.org/10.1046/j.1529-8019.2003.01625.x
OrÅ¡oliÄ‡ N, SkuriÄ‡ J, DikiÄ‡ D, StaniÄ‡ G. Inhibitory effect of a propolis on di-n-propyl disulfide or n-hexyl salycilate-induced skin irritation, oxidative stress and inflammatory responses in mice. Fitoterapia. 2014; 93:18-30. https://doi.org/10.1016/j.fitote.2013.12.007 PMid:24370661
Hashemi SA, Madani SA, Abediankenari S. The review on properties of Aloe vera in healing of cutaneous wounds. Bio Med Res Intern. 2015; 2015:714216. https://doi.org/10.1155/2015/714216
HercogovÃ¡ J, Ricceri F, Tripo L, Lotti T, Prignano F. Psoriasis and body mass index. Dermatol Ther. 2010; 23(2):152-4. https://doi.org/10.1111/j.1529-8019.2010.01309.x PMid:20415822
Lotti T, Hercogova J, Prignano F. The concept of psoriatic disease: can cutaneous psoriasis any longer be separated by the systemic comorbidities? Dermatol Ther. 2010; 23(2):119-22. https://doi.org/10.1111/j.1529-8019.2010.01305.x PMid:20415818
Pasupuleti VR, Sammugam L, Ramesh N, Gan SH. Honey, Propolis, and Royal Jelly: A Comprehensive Review of Their Biological Actions and Health Benefits. Oxid Med Cell Longev. 2017; 2017:1259510. https://doi.org/10.1155/2017/1259510 PMid:28814983 PMCid:PMC5549483
Wahedi HM, Jeong M, Chae JK, Do SG, Yoon H, Kim SY. Aloesin from Aloe vera accelerates skin wound healing by modulating MAPK/Rho and Smad signaling pathways in vitro and in vivo. Phytomedicine. 2017; 28:19-26. https://doi.org/10.1016/j.phymed.2017.02.005 PMid:28478809
Choonhakarn C, Busaracome P, Sripanidkulchai B, Sarakarn P. A prospective, randomized clinical trial comparing topical aloe vera with 0.1% triamcinolone acetonide in mild to moderate plaque psoriasis. J Eur Acad Dermatol Venereol. 2010 Feb; 24(2):168-72. https://doi.org/10.1111/j.1468-3083.2009.03377.x PMid:19686327
How to Cite