Is There a Place for Local Natural Treatment of Psoriasis?


  • Agharid El-Gammal Department of Nuclear, Subnuclear and Radiation Physics, University of Rome “G. Marconi”, Rome
  • Veronica Di Nardo Department of Nuclear, Subnuclear and Radiation Physics, University of Rome “G. Marconi”, Rome
  • Farah Daaboul Institute of Dermatological and Regenerative Sciences, Dermatology and Nutrition, Via Alfieri 28, Florence 50121
  • Georgi Tchernev Medical Institute of Ministry of Interior (MVR-Sofia), Department of Dermatology, Venereology and Dermatologic Surgery General Skobelev Nr 79, Sofia 1606, Bulgaria; Onkoderma - Policlinic for Dermatology and Dermatologic Surgery, General Skobelev 26, Sofia 1407
  • Uwe Wollina Städtisches Klinikum Dresden, Department of Dermatology and Allergology, Academic Friedrichstrasse 41, Dresden 01067
  • Jacopo Lotti University G. Marconi of Rome, Dept. of Nuclear, Subnuclear and Radiation Physics, Rome
  • Torello Lotti Università Degli Studi "G. Marconi”, Institute of Dermatology, Rome



Apitherapy, Psoriasis, Skin disease, Natural therapy, Propolis, Aloe vera


BACKGROUND: Apitherapy is the medical use of honey bee products (honey, propolis, royal jelly, bee wax, and bee venom) to relieve human ailments, propolis in particularly, rich in essential oils such as flavonoid. Propolis is derived from tree buds and plants. It is considered as one of the most well-documented products from the honeybee and has always played an important role in traditional folk medicine. Another renowned plant is Aloe vera appertaining to the Liliaceae family. Its mucilaginous gel has been extensively used in many cultures for its apparent effectiveness in treating wounds, burns, itchiness and hair loss.

AIM: The aim was to assess the efficacy of a mixture in an ointment form of propolis (50%) and aloe vera (3%), in the treatment of mild to moderate psoriasis.

METHODS: In this double-blind control study, 2248 patients with both mild to moderate cases of psoriasis were evaluated from 2012 to 2015.

RESULTS: In Group 1 the overall response at the end of 12 weeks was as follows: Cleared in 64.4% (excellent response), good response in 22.2%, and weak response in 5.6% and no response in 7.7%. In Group 2 (placebo group) no significant improvement was observed after 12 weeks of treatment. Also, histology also demonstrated a marked reduction in hyperkeratosis and acanthosis.

CONCLUSION: In comparison with Group 2 (placebo group) patients in Group 1, treated with a mixture of propolis (50%) and aloe vera (3%), in the form of an ointment have shown noteworthy improvement thus substantiating the therapeutic value of propolis and aloe vera in the treatment of mild to moderate psoriasis.


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How to Cite

El-Gammal A, Di Nardo V, Daaboul F, Tchernev G, Wollina U, Lotti J, Lotti T. Is There a Place for Local Natural Treatment of Psoriasis?. Open Access Maced J Med Sci [Internet]. 2018 May 18 [cited 2024 May 24];6(5):839-42. Available from:



B - Clinical Sciences

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