Absent 99mTc-MIBI Uptake in the Thyroid Gland during Early Phase of Parathyroid Scintigraphy in Patients with Primary and Secondary Hyperparathyroidism

Authors

  • Anamarija Jovanovska Institute of Pathophysiology and Nuclear Medicine, Medical Faculty, Ss. Cyril and Methodius University of Skopje, Skopje
  • Bojana Stoilovska Institute of Pathophysiology and Nuclear Medicine, Medical Faculty, Ss. Cyril and Methodius University of Skopje, Skopje
  • Magdalena Mileva Institute of Pathophysiology and Nuclear Medicine, Medical Faculty, Ss. Cyril and Methodius University of Skopje, Skopje
  • Daniela Miladinova Institute of Pathophysiology and Nuclear Medicine, Medical Faculty, Ss. Cyril and Methodius University of Skopje, Skopje
  • Venjamin Majstorov Institute of Pathophysiology and Nuclear Medicine, Medical Faculty, Ss. Cyril and Methodius University of Skopje, Skopje
  • Ana Ugrinska Institute of Pathophysiology and Nuclear Medicine, Medical Faculty, Ss. Cyril and Methodius University of Skopje, Skopje

DOI:

https://doi.org/10.3889/oamjms.2018.118

Keywords:

Parathyroid scintigraphy, Diminished thyroid MIBI uptake, Primary hyperparathyroidism, Chronic renal failure

Abstract

BACKGROUND: Thyroid uptake of technetium-99m methoxyisobutylisonitrile (99mTc-MIBI) during parathyroid scintigraphy can be affected by various conditions.

AIM: To evaluate the frequency of absent 99mTc-MIBI uptake by the thyroid gland in the early phase of dual-phase parathyroid scintigraphy.

METHODS: The early planar images of dual phase Tc99m MIBI parathyroid scintigraphy from 217 patients performed between 2014 and 2017 were retrospectively analysed. Patients were divided into two groups. The first group included 147 patients with primary hyperparathyroidism and the second group included 70 patients with chronic renal failure. Patient records, laboratory and ultrasonographic data were analysed in all patients. Descriptive statistic was used for data analysis.

RESULTS: Out of all patients in the first group, 18 patients (12.24%) showed absent thyroid uptake. Thyroidectomy was performed in 44.4% of these patients, and the rest of them had some thyroid disease. Only one patient had no thyroid or another chronic disease. In the second group, 8 patients (11.42%) presented with absent thyroid uptake of MIBI. Among them, 5 patients had no history of thyroid disease and had been on hemodialysis programme, and 3 patients had hypothyroidism.

CONCLUSION: Absent 99mTc-MIBI uptake in the thyroid during the early phase of parathyroid scintigraphy is most frequently related to thyroid disease. A small proportion of patients with chronic renal failure can present with absent 99mTc-MIBI uptake in the thyroid as well. The mechanism for this alteration is still unclear and needs further investigation.

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Published

2018-05-14

How to Cite

1.
Jovanovska A, Stoilovska B, Mileva M, Miladinova D, Majstorov V, Ugrinska A. Absent 99mTc-MIBI Uptake in the Thyroid Gland during Early Phase of Parathyroid Scintigraphy in Patients with Primary and Secondary Hyperparathyroidism. Open Access Maced J Med Sci [Internet]. 2018 May 14 [cited 2024 Mar. 29];6(5):808-13. Available from: https://oamjms.eu/index.php/mjms/article/view/oamjms.2018.118

Issue

Section

B - Clinical Sciences

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