Angiotensin-Converting Enzyme (ACE) D Allele as a Risk Factor for Increase Serum Interleukin-6 and Interleukin-8 in Psoriasis Patients

Ahmed I. Abd Elneam; Mohammed Saleh Al-Dhubaibi; Ali Ismaiel Ali Abd Alrheam

doi:10.3889/oamjms.2018.188

Authors

Ahmed I. Abd Elneam Molecular Genetics and Enzymology Department, Human Genetics Division, National Research Centre, 33 El Bohouth St. (former El Tahrir St.), Dokki 12622, Cairo, Egypt; Department of Clinical Biochemistry, Faculty of Medicine Al-dawdmi, Shaqra University
Mohammed Saleh Al-Dhubaibi Department of Dermatology, Faculty of Medicine Addawdmi, Shaqra University
Ali Ismaiel Ali Abd Alrheam Department of Clinical Laboratory, Faculty of Applied Medical Science Al-dawdmi, Shaqra University

DOI:

https://doi.org/10.3889/oamjms.2018.188

Keywords:

ACE polymorphism, Serum IL-6, serum IL-8, Psoriasis

Abstract

BACKGROUND: Psoriasis is a chronic, recurrent inflammatory skin disease. It is characterised by autoimmune, environmental factors and complex genetic disorder.

AIM: To explore the role of IL-6, IL-8, and ACE I/D polymorphism in the pathogenesis of Psoriasis and investigation of the relationship between ACE polymorphism and occurrence of psoriasis.

PATIENTS AND METHODS: In this study, we took 73 psoriasis patients and 47 healthy patients as a control. These two groups subjected to analysis for ACE gene I/D polymorphism by PCR and biochemical methods.

RESULTS: The serum levels of ACE, IL-8 and IL-6 were statistically significantly higher in psoriasis patients compared to healthy subjects (P < 0.001). ID and DD polymorphism were more common in psoriasis patients than healthy subjects. Also, D allele was significantly over-represented in patients compared to controls (52.7% Vs 35.1%).

CONCLUSION: ACE gene polymorphism might grant susceptibility to develop psoriasis.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Plum Analytics Artifact Widget Block

References

Griffiths CE, Barker JN. Pathogenesis and clinical features of psoriasis. Lancet. 2007; 370:263-71. https://doi.org/10.1016/S0140-6736(07)61128-3

Mee JB, Johnson CM, Morar N, Burslem F, Groves RW. The psoriatic transcriptome closely resembles that induced by interleukin-1 in cultured keratinocytes: dominance of innate immune responses in psoriasis. Am J Pathol. 2007; 17(1): 32-42. https://doi.org/10.2353/ajpath.2007.061067 PMid:17591951 PMCid:PMC1941577

Zachariae H. Prevalence of joint disease in patients with psoriasis: implications for therapy. Am J Clin Dermatol. 2003; 4(7):441-7. https://doi.org/10.2165/00128071-200304070-00001 PMid:12814334

Rigat B1, Hubert C, Alhenc-Gelas F, Cambien F, Corvol P, Soubrier F. An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest. 1990; 86(4): 1343â€“6. https://doi.org/10.1172/JCI114844 PMid:1976655 PMCid:PMC296868

Jin SY, Park HH, Li GZ, Lee HJ, Hong MS, Hong SJ, et al. Association of Angiotensin Converting Enzyme Gene I/D Polymorphism of Vitiligo in Korean Polymorphism. Pigment Cell Res. 2004; 17(1): 84â€“6. https://doi.org/10.1046/j.1600-0749.2003.00105.x PMid:14717849

Scholzen TE, StÃ¤nder S, Riemann H, Brzoska T, Luger TA. Modulation of cutaneous inflammation by the angiotensin-converting enzyme. J Immunol. 2003; 170(7):3866â€“73. https://doi.org/10.4049/jimmunol.170.7.3866 PMid:12646655

Takahashi T, Taniguchi T, Okuda M, Takahashi A, Kawasaki S, Domoto K, et al. Participation of reactive oxygen intermediates in the angiotensin II-activated signalling pathways in vascular smooth muscle cells. Ann NY Acad Sci. 2000; 902: 283â€“7. https://doi.org/10.1111/j.1749-6632.2000.tb06323.x PMid:10865848

Beazley WD, Gaze D, Panske A, Panzig E, Schallreuter KU. Serum selenium levels and blood glutathione peroxidase activities in vitiligo. Br J Dermatol. 1999; 141(2):301â€“3. https://doi.org/10.1046/j.1365-2133.1999.02980.x PMid:10468804

Nickoloff BJ, Nestle FO. Recent insights into the immunopathogenesis of psoriasis provide new therapeutic opportunities. J Clin Invest. 2004; 113(12):1664â€“75. https://doi.org/10.1172/JCI200422147

Yildirim M, Baysal V, Inaloz HS, Can M. The role of oxidants and antioxidants in generalized vitiligo at tissue level. J Eur Acad Dermatol Venereol. 2004; 18(6):683â€“6. https://doi.org/10.1111/j.1468-3083.2004.01080.x PMid:15482295

Borden EC, Chin P. Interleukin-6: a cytokine with potential diagnostic and the therapeutic roles. J Lab Clin Med. 1994; 123(6):824-9. PMid:8201259

Castells-Rodellas A, Castell JV, Ramirez-Bosca A, Nicolas JF, Valcuende-Cavero F, Thivolet J. Interleukin-6 in normal skin and psoriasis. Acta Derm Venereol. 1992; 72(3):165â€“8. PMid:1357848

Gearing AJ, Fincham NJ, Bird CR, Wadhwa M, Meager A, Cartwright JE et al. Cytokines in skin lesions of psoriasis. Cytokine. 1990; 2(1):68â€“75. https://doi.org/10.1016/1043-4666(90)90045-U

Antilla HSI, Reitamo S, Erkko P, Ceska M, Moser B, Baggiolini M. Interleukin-8 immunoreactivity in the skin of healthy subjects and patients with palmoplantar pustulosis and psoriasis. J Invest Dermatol. 1992; 98(1): 96-101. https://doi.org/10.1111/1523-1747.ep12495817

Baggiolini M, Dewald B, Moser B. Human chemokines: an update. Annu Rev Immunol. 1997; 15: 675-705. https://doi.org/10.1146/annurev.immunol.15.1.675 PMid:9143704

Ramsay B, Lawrence CM. Measurement of involved surface area in patients with psoriasis. Br J Dermatol. 1991; 124: 565-70. https://doi.org/10.1111/j.1365-2133.1991.tb04952.x PMid:2064940

Wang P, Holst C, Wodzig W, Andersen M, Astrup A, van Baak M et al. Circulating ACE is a predictor of weight loss maintenance not only in overweight and obese women, but also in men. Int J Obes (Lond). 2012; 36(12):1545-51. https://doi.org/10.1038/ijo.2011.278 PMid:22270380

MÃ¤rz P, Cheng JG, Gadient RA, Patterson PH, Stoyan T, Otten U, et al. Sympathetic neurons can produce and respond to interleukin 6. Proc Natl Acad Sci USA. 1998; 95(6): 3251â€“6. https://doi.org/10.1073/pnas.95.6.3251 PMid:9501249 PMCid:PMC19728

Sticherling M, Hetzel F, Schroder J-M, Christophers E. Time-and stimulus-dependent secretion of NAP-1/IL-8 by human fibroblasts and endothelial cells. J Invest Dermatol. 1993; 101(4): 573-6. https://doi.org/10.1111/1523-1747.ep12366023 PMid:8409526

Dehwah MA, Shunag Z, Huang Q Y. The Association Between ACE Gene I/D Polymorphism and Type 2 Diabetes in Han Chinese in Hubei. Int J Osteop Meta Disor. 2008; 1(1):1-7.

https://blast.ncbi.nlm.nih.gov/Blast.cgi.

Kapp A, Piskorski A, Schopf E. Elevated levels of interleukin 2 receptor in sera of patients with atopic dermatitis and psoriasis. British Journal of Dermatology.1988; 119(6):707â€“710. https://doi.org/10.1111/j.1365-2133.1988.tb03491.x PMid:3264510

Abanmi A, Al Harthi F, Al Agla R, Khan HA, Tariq M. Serum levels of proinflammatory cytokines in psoriasis patients from Saudi Arabia. Int J Dermatol. 2005; 44(1):82â€“83. https://doi.org/10.1111/j.1365-4632.2004.02082.x PMid:15663670

Zalewska A, GÅ‚owacka E, WyczÃ³Å‚kowska J, TchÃ³rzewski H, Narbutt J, Sysa-Jedrzejowska A. Interleukin 6 and 8 levels in plasma and fibroblast cultures in psoriasis. Mediators Inflamm. 2006; 2006(1):81767. https://doi.org/10.1155/MI/2006/81767

Song GG, Bae SC, Kim JH, Lee YH. The angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to rheumatoid arthritis, vitiligo and psoriasis: A meta-analysis. J Renin Angiotensin Aldosterone Syst. 2015; 16(1):195-202. https://doi.org/10.1177/1470320313478285 PMid:23413281

Min Huang, Guo-Dong Huang. Dan Peng. Angiotensin-converting enzyme I/D polymorphism and susceptibility of psoriasis. Biomedical Research. 2017; 28(12):5450-3.

Rajesh D, Gurumurthy R, Kutty AV, Balakrishna S. Tumor necrosis factor-alpha gene promoter -238G/A polymorphism increases the risk of psoriasis vulgaris in Indian patients. Int J Dermatol. 2017; 56:307-311. https://doi.org/10.1111/ijd.13482 PMid:28093730

Zablotna M, Sobjanek M, Purzycka-Bohdan D, Szczerkowska-Dobosz A, Nedoszytko B, Nowicki R. The -2518 A/G MCP-1 and -403 G/A RANTES promoter gene polymorphisms are associated with psoriasis vulgaris. Clin Exp Dermatol. 2016; 41(8): 878-83. https://doi.org/10.1111/ced.12937 PMid:27859608

Shi G, Li SJ, Wang TT, Cheng CM, Fan YM, Zhu KJ. The common CARD14 gene missense polymorphism rs11652075 (c.C2458T/ p.Arg820Trp) is associated with psoriasis: a meta-analysis. Genet Mol Res. 2016; 15(3). https://doi.org/10.4238/gmr.15038357

Ehlers MR, Riordan JF. Angiotensin-converting enzyme: new concepts concerning its biological role. Biochemistry. 1989; 28(13):5311â€“8. https://doi.org/10.1021/bi00439a001

Schremmer-Danninger E, Hermann A, Fink E, Fritz H, Roscher AA. Identification and occurrence of mRNAs for components of the kallikrein-kinin system in human skin and in skin diseases. Immunopharmacology.1999; 43(2-3):287â€“91. https://doi.org/10.1016/S0162-3109(99)00100-9