Brucellosis as the Cause of Non-Viral Bacterial Hepatitis: A Case Report

Bilger Ã‡avuÅŸ; Ã–zge Ã‡aydaÅŸÄ±; Ahmet Aktan; Ercan Ayaz

doi:10.3889/oamjms.2018.198

Authors

Bilger Ã‡avuÅŸ BingÃ¶l State Hospital, Gastroenterology Department
Ã–zge Ã‡aydaÅŸÄ± BingÃ¶l State Hospital, Infectious Disease Department
Ahmet Aktan BingÃ¶l State Hospital, Radiology Department
Ercan Ayaz BingÃ¶l State Hospital, Radiology Department

DOI:

https://doi.org/10.3889/oamjms.2018.198

Keywords:

Brucellosis, Acute hepatitis, Liver transaminases

Abstract

BACKGROUND: Brucellosis can lead to different clinical pictures such as hepatomegaly, granulomatous liver disease, hepatic abscess, and it can cause mild hepatic transaminase elevation in the laboratory investigations.

CASE REPORT: We found out that the etiologic agent was Brucella in our two cases admitted with acute hepatitis presentation in the investigations conducted. Liver transaminases were as follows for case 1 and case 2; AST: 306/187U/L, ALT: 368/312U/L, ALP: 355/264U/L, GGT: 116/197U/L, LDH: 887/549U/L, respectively. Sacroiliitis also accompanied the clinical picture in our first case. Our patients showed clinical and laboratory improvement with rifampicin, doxycycline, (additional streptomycin for 21 days in the patient with sacroiliitis) treatment.

CONCLUSION: Brucellosis which may manifest as a clinical picture regarding numerous medical branches should be considered in case of acute hepatitis, especially in endemic regions, along with viral hepatitis.

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References

Avila-CalderÃ³n ED, Lopez-Merino A, Sriranganathan N, Boyle SM, Contreras-RodrÃguez A. A history of the development of Brucella vaccines. BioMed research international. 2013;2013.

Tumwine G, Matovu E, Kabasa JD, Owiny DO, Majalija S. Human brucellosis: seroprevalence and associated risk factors in agro-pastoral communities of Kiboga District, Central Uganda. BMC public health. 2015; 15(1):900. https://doi.org/10.1186/s12889-015-2242-z PMid:26374402 PMCid:PMC4572625

Pappas G, Akritidis N, Bosilkovski M, Tsianos E. the b. melitensis genome. N Engl J Med. 2005; 352:2325-36. https://doi.org/10.1056/NEJMra050570 PMid:15930423

Cervantes F, Carbonell J, Bruguera M, Force L, Webb S. Liver disease in brucellosis. A clinical and pathological study of 40 cases. Postgraduate medical journal. 1982; 58(680):346-50. https://doi.org/10.1136/pgmj.58.680.346 PMid:7122367 PMCid:PMC2426342

Ã‡iftdoÄŸan DY, Aslan S. Unrecognized pediatric and adult family members of children with acute brucellosis. The Brazilian Journal of Infectious Diseases. 2017; 21(5):520-4. https://doi.org/10.1016/j.bjid.2017.05.006 PMid:28623676

Erdem H, Akova M. Leading infectious diseases problems in Turkey. Clinical Microbiology and Infection. 2012; 18(11):1056-67. https://doi.org/10.1111/1469-0691.12000 PMid:23043613

GÃ¼rsoy B, Tekin-Koruk S, SÄ±rmatel F, KaraaÄŸaÃ§ L. Bruselloz: 140 olgunun deÄŸerlendirilmesi. Klimik Derg. 2008; 21(3):101-4.

Demir MI, Kader Ã‡, Ã‡olak NY, Kocabiyik O, Erbay A, Åžebnem ER. Evaluation of Brucellosis Cases. Bozok TÄ±p Dergisi. 2017; 7(3):47-51.

Denk A, Ozden M. A case of brucellosis presenting with acute hepatitis and bicytopenia. Le infezioni in medicina: rivista periodica di eziologia, epidemiologia, diagnostica, clinica e terapia delle patologie infettive. 2015; 23(2):178-81.