IGF1R Gene Alterations in Small for Gestational Age (SGA) Children

Authors

  • Aleksandra Janchevska University Children's Hospital, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje
  • Aleksandar Dimovski Macedonian Academy of Sciences and Arts, Skopje
  • Kristina Mironska University Children's Hospital, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje
  • Velibor Tasic University Children's Hospital, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje
  • Zoran Gucev University Children's Hospital, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje

DOI:

https://doi.org/10.3889/oamjms.2018.209

Keywords:

SGA born children, Microcephaly, Short stature, Exon 2 of IGF1R gene, Gene analysis

Abstract

BACKGROUND: Small for gestational age children (SGA) is born on term with BW and or BL of -2.0 standard deviation score (SDS). SGA children have an increased risk of being short, developing DM, and cardiovascular and cerebrovascular disease. Often defects of IGF1R are the cause of SGA. Most frequently affected part of the IGF1R gene is the exon 2.

AIM: To investigate whether the exon 2 of the IGF1R gene is affected in the SGA children.

PATIENTS AND METHODS: A cohort of 100 SGA children born in term was evaluated for alterations in IG1R gene. Their anthropometric parameters, IGF1 serum concentrations and IGF1 SDS values were analysed. The molecular analysis of IGF1R gene was performed by PCR restriction-site analysis and followed by direct sequencing of conspicuous fragments.

RESULTS: Within our cohort, 64 SGA children were with short stature (height SDS -3.25 ± 0.90 SDS), and 36 were with normal height for their age and sex, (H SDS was 0.20 ± 1.1 SDS). None of these children had microcephaly (occipitofrontal circumference -0.70 ± 1.01 SDS vs 0.06 ± 0.56 SDS in SGA children with normal height) or dysmorphic features. The IGF1 serum concentrations and IGF1 SDS values of all children were within normal range. Only one child had lower normal serum IGF1 concentration. No alterations in exon 2 of IGF1R gene were detected.

CONCLUSIONS: The genetic analysis of the exon 2 of the IGF1R gene did not detect any gene defects in the analysed patients. The putative genetic defect in those children affects other parts of the IGF1R gene or another gene (s), or yet unidentified factors.

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Published

2018-05-13

How to Cite

1.
Janchevska A, Dimovski A, Mironska K, Tasic V, Gucev Z. IGF1R Gene Alterations in Small for Gestational Age (SGA) Children. Open Access Maced J Med Sci [Internet]. 2018 May 13 [cited 2022 Jan. 24];6(5):790-3. Available from: https://oamjms.eu/index.php/mjms/article/view/oamjms.2018.209

Issue

Section

B - Clinical Sciences

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