Assessment of Laser Biostimulation in Induction of Ovulation


  • Mohamed A. El-Nourya Department of Obstetrics & Gynecology, National Institute of Laser Enhanced Science (NILES), Cairo University, Cairo
  • Mahmoud B. El-Begawyb Department of Pathology, Faculty of Veterinary Medicine, BeniSeuf University, Cairo
  • Mona E. Morsyc Department of Photobiology, National Institute of Laser Enhanced Science (NILES), Cairo University, Cairo
  • Ehab M. Al Sherbiny Department of Obstetrics & Gynecology, Nasr City Hospital for Surgery, Ministry of Health & Population, Cairo



Laser, Biostimulation, Induction, Ovulation


AIM: This study aimed to evaluate a new modality of low power laser biostimulation in rat ovaries, in comparison with the conventional medical therapy by clomiphene citrate that depends on up-regulation of the hypothalamic-pituitary-ovarian axis to induce ovulation.

STUDY DESIGN: A Prospective experimental study carried out from January 2014 to February 2016.

SETTING: University-based photobiology laboratory.

MATERIALS AND METHODS: Seventy-two (72) Female-Wistar Albino rats were used in this study, divided into three groups: 17 rats used as a control group, 19 rats received clomiphene citrate (Clomid group), 36 rats exposed to diode laser 660 nm wavelength (laser group).

RESULTS: Biochemical assessment of serum Estradiol and serum Progesterone was done in the three study groups. Serum Estradiol & Progesterone levels were statistically significantly higher in clomiphene and laser treated groups than non-interventional controls, while no significant difference between clomiphene and laser groups as regard of both hormones.

CONCLUSION: This study shows that ovarian laser biostimulation is a new encouraging method for induction of ovulation, at least in animals. This had been proven biochemically by a significant increase in serum Estradiol and serum Progesterone.


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Author Biography

Ehab M. Al Sherbiny, Department of Obstetrics & Gynecology, Nasr City Hospital for Surgery, Ministry of Health & Population, Cairo

National Institute Of Laser Enhanced Science, Department of Medical Laser Application ( Gynecology Unit)


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How to Cite

El-Nourya MA, El-Begawyb MB, Morsyc ME, Al Sherbiny EM. Assessment of Laser Biostimulation in Induction of Ovulation. Open Access Maced J Med Sci [Internet]. 2018 Jun. 25 [cited 2021 Jun. 25];6(7):1193-8. Available from:



A - Basic Science