The Role of CYP2A6 Genetic Polymorphism in Nicotine Dependence and Tobacco Consumption among Bataknese Male Smokers
DOI:
https://doi.org/10.3889/oamjms.2018.224Keywords:
Polymorphism of CYP2A6 gene, Nicotine Dependence, Bataknese, Brinkman IndexAbstract
AIM: This research aimed to analyse the relationship between CYP2A6 gene polymorphism with nicotine dependence and its relation to the number of cigarette consumption among Bataknese smokers.
METHOD: This study was a cross-sectional study involving 140 research subjects in Medan, Indonesia.
RESULTS: Nicotine dependence rates were found to be significantly associated with the number of cigarette consumption expressed in the Brinkman Index.
CONCLUSION: The *1A wild-type alleles have a greater risk of high-very high dependence rate compared to the other variants.
Downloads
Metrics
Plum Analytics Artifact Widget Block
References
World Health Organization: The Facts About Smoking and Health, May 30, 2006. http://www.wpro.who.int/media_centre/ fact_sheets/fs_20060530.htm.
Hukkanen J, Jacob P, Benowitz N. Metabolism and disposition kinetics of nicotine. Pharmacol Rev. 2005; 57(1):79-115. https://doi.org/10.1124/pr.57.1.3 PMid:15734728
Tyndale RF, Sellers EM. Genetic variation in CYP2A6-mediated nicotine metabolism alters smoking behaviour. Therapeutic Drug Monitoring. 2002; 24:163–171. https://doi.org/10.1097/00007691-200202000-00026
O'Brian CP. Drug Addiction and Drug Abuse', In Brunton LL, Lazo JS & Parker KL, Goodman & Gilman's. 11th Ed. The Pharmacological Basis of Therapeutics, 2006:607-628.
Heatherton TF, Kozlowski LT, Frecker RC, Fagerstrom KO. The Fagerstrom test for nicotine dependence, a revision of The Fagerstrom Tolerance Questionnaire. Br J Addict. 1991; 86:1119-27. https://doi.org/10.1111/j.1360-0443.1991.tb01879.x PMid:1932883
Siregar AP. Determinan perilaku merokok siswa sekolah dasar di Desa Simatahari Kecamatan Kota Pinang Kabupaten Labuhan Batu Selatan [Tesis]. Universitas Sumatera Utara, 2015.
Ryan H, Trosclair A, Gfroerer J. Adult current smoking: Differences in definitions and prevalence estimates-NHIS and NSDUH 2008. Journal of Environmental and Public Health. 2012; 2012.
Perhimpunan Dokter Paru Indonesia (PDPI). Penyakit Paru Obstruktif Kronik (PPOK): diagnosis dan penatalaksanaan. PPOK Books, 2011.
Benowitz NL. Cotinine is a biomarker of environmental tobacco smoke exposure. Epidemiol Rev. 1996; 18(2):188-204. https://doi.org/10.1093/oxfordjournals.epirev.a017925 PMid:9021312
Nakajima M, Yoshida R, Fukami T, McLeod HL, Yokoi T. Novel human CYP2A6 alleles confound gene deletion analysis. FEBS Lett. 2004; 569(1-3):75-81. https://doi.org/10.1016/j.febslet.2004.05.053 PMid:15225612
Downloads
Published
How to Cite
Issue
Section
License
http://creativecommons.org/licenses/by-nc/4.0