How to Improve Clinical Outcome of Epileptic Seizure Control Based on Medication Adherence? A Literature Review
DOI:
https://doi.org/10.3889/oamjms.2018.235Keywords:
Antiepileptic drug, Epileptic, Seizure, AdherenceAbstract
Anti-Epileptic Drugs (AEDs) are the main therapy for epilepsy to prevent seizures. Non-adherence situation plays an important factor in the failure of seizure control. Such a condition may generate several impacts on clinical, social, and economic aspect. Several methods are used to measure adherence in epilepsy patients, including direct and indirect measurement. The direct measure involves measurement of drug levels in hair or body fluids such as blood and saliva. Whereas, indirect measure involves the non-biological tools, for example, a self-report measure, pill counts, appointment attendance, medication refills, and seizure frequency. Numerous factors may affect adherence in epilepsy patients, such as age, sex, and seizure aetiology, seizure sites, which are categorised as irreversible factors and hardly to be improved. However, there are factors that can be influenced to improve adherence such as patient knowledge, medication, cultural, health care professionals, and national health policies, which are related to treatment and education factor which is associated with behaviour to be likely adherence.Downloads
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References
Leach JP, Davenport RJ. Neurological Disease. In : Walker, BR, Colledge, NR, Ralston, SH, Penman, ID. (Eds). Davidson's Principles & Practice of Medicine 22th ed. London: Churchill Livingstone Elsevier, 2014.
Aminoff M, dan Douglas V. Nervous System Disorders. In : Papadakis, MA, McPhee, SJ, Rabow, MW. (Eds). Current Medical Diagnosis & Treatment 56th ed. New York : McGraw Hill Education, 2017: 983-90.
Glauser T, Shinnar S, Gloss D, Alldredge B, Arya R, Bainbridge, et al. Evidence-Based Guideline: Treatment of Convulsive Status Epilepticus in Children and Adults: Report of The Guideline Committee of American Epilepsy Society. Epilepsy Currents. 2016; 16(1):48-61. https://doi.org/10.5698/1535-7597-16.1.48 PMid:26900382 PMCid:PMC4749120
WHO, 2017. World Health Organization Fact Sheet: Epilepsi, updated February 2017. Available from: http://www.who.int/en/news-room/fact-sheets/detail/epilepsy
Elger CE, Schmidt D. Modern management of epilepsy: a practical approach. Epilepsy Behav. 2008; 12: 501-39. https://doi.org/10.1016/j.yebeh.2008.01.003 PMid:18314396
Hao XT, Kwan P. Update and overview of the International League against Epilepsy consensus definition of drug-resistant epilepsy. Eur Neurol Rev. 2011; 6(1):57-9. https://doi.org/10.17925/ENR.2011.06.01.57
Fisher RS, Shafer PO, Sirven JI. Refractory seizures. Epilepsy Foundation Available from: http:// www.epilepsy.com/learn/typesseizures/refractory-seizures. [Accesed 4 May 2018]
Cramer JA, Glassman M, Rienzi V. The relationship between poor medication compliance and seizures. Epilepsy Behav. 2002; 3: 338-42. https://doi.org/10.1016/S1525-5050(02)00037-9
Gabr, WM, Shams, M. Adherence to medication among outpatient adolescents with epilepsy. Saudi Pharmaceutical Journal. 2015; 23: 33–40. https://doi.org/10.1016/j.jsps.2014.05.003 PMid:25685041 PMCid:PMC4311017
Davis KL, Candrilli SD, Edin ME. Prevalence and cost of non-adherence with antiepileptic drugs in an adult managed care population. Epilepsia. 2008; 49 (3): 446–54. https://doi.org/10.1111/j.1528-1167.2007.01414.x PMid:18031549
Faught RE, Duh MS, Weiner JR, Guerin A, Cunnington C. Non-adherence to antiepileptic drugs and increased mortality: findings from the RANSOM study. Neurology. 2008; 71(20): 1572–8. https://doi.org/10.1212/01.wnl.0000319693.10338.b9 PMid:18565827
Molugulu N, Gubbiyappa KS, Vasudeva Murthy CR, Lumae L, Mruthyunjaya AT. Evaluation of self reported medication adherence and its associated factors among epilepsy patients in Hospital Kuala Lumpur. J Basic Clin Pharma. 2016; 7: 105 9. https://doi.org/10.4103/0976-0105.189430 PMid:27999469 PMCid:PMC5153886
WHO. Adherence to long-term therapies. Evidence for action. Geneva: World Health Organization. 2003. Available from: http://www. apps.who.int/medicinedocs/en/d/Js4883e/ [Accesed 4 May 2018]
Howard RL. Compliance, adherence and concordance. In: Whalley, BJ., Fletcher, KE., Weston, SE., Howard, RL, Rawlinson, CF. (eds). Foundation in Pharmacy Practice. London: Pharmaceutical Press, 2008:135-50. PMid:18500715
Shams ME, Barakat EA. Measuring the rate of therapeutic adherence among outpatients with T2DM in Egypt. Saudi Pharm J. 2010; (4): 225. https://doi.org/10.1016/j.jsps.2010.07.004 PMid:23960731 PMCid:PMC3730985
Burkhart PV, Sabaté E. Adherence to long term therapies: evidence for action. J Nurs Scholarsh. 2003; 35(3): 207. PMid:14562485
Losada-Camacho M, Guerrero-Pabon M, Garcia-Delgado P, Martineze F. Impact of a pharmaceutical care programme on health-related quality of life among women with epilepsy: a randomised controlled trial (IPHIWWE study). Health and Quality of Life Outcomes. 2014; 12:162. https://doi.org/10.1186/s12955-014-0162-8 PMid:25358723 PMCid:PMC4236797
Dash D, Sebastian TM, Aggarwal M, Tripathi M. Impact of health education on drug adherence and self care in people with epilepsy with low education. Epilepsy & Behavior. 2015: 44; 213–17. https://doi.org/10.1016/j.yebeh.2014.12.030 PMid:25768712
Skinner HJ, Durbon-Murcia SA, Thompson AR, Medina MT, Edwards JC, Nicholas JS, et al. Adult convulsive status epilepticus in the developing country of Honduras. Seizure. 2010; 19(6): 363–7. https://doi.org/10.1016/j.seizure.2010.05.007 PMid:20554456
O'Rourke G, O'Brien JJ, Review. Identifying the barriers to antiepileptic drug adherence among adults with epilepsy. Seizure. 2017; 45: 160–8. https://doi.org/10.1016/j.seizure.2016.12.006 PMid:28063375
Paschal, AM, Hawley, SR Romain, TS, and Ablah, E, Measures of adherence to epilepsy treatment: Review of present practices and recommendations for future directions. Epilepsia. 2008; 49 (7):1115-22. https://doi.org/10.1111/j.1528-1167.2008.01645.x PMid:18479395
Getnet A, Meseret S. Antiepileptic Drug Non-adherence and Its Predictors among People with Epilepsy. Behavioral Neurology. 2016; 6: 3189108.
Shallcross AJ, Becker AB, Singh A, Friendman D, Jurd R, French JA, et al. Psychosocial factors associated with medication adherence in ethically and socioeconomically diverse patients with epilepsy. Epilepsy Behav. 2015; 46: 242–5. https://doi.org/10.1016/j.yebeh.2015.01.034 PMid:25847430 PMCid:PMC4701194
Claxton AJ, Cramer J, Pierce C. A systematic review of the associations between dose regimens and medication compliance. Clin Ther. 2001; 23: (8)1296–1310. https://doi.org/10.1016/S0149-2918(01)80109-0
Ferrari CM, De Sousa RM, Castro LH. Factors associated with treatment non-adherence in patients with epilepsy in Brazil. Seizure. 2013; 22: 384–89. https://doi.org/10.1016/j.seizure.2013.02.006 PMid:23478508
Gurumurthy R, Chanda K, Sarma. An evaluation of factors affecting adherence to antiepileptic drugs in patients with epilepsy: a cross-sectional study. Singapore Med J. 2017; 58 (2): 98-102. https://doi.org/10.11622/smedj.2016022 PMid:26805666 PMCid:PMC5311891
Haynes RB, Yao X, Degani A, Kripalani S, Garg A, McDonald HP. Interventions to enhance medication adherence. Cochrane Database Syst Rev. 2005; 4:CD000011.
Hovinga CA, Asato MR, Manjunath R, Wheles JW, Phelps SJ, Sheth RD. Association of non-adherence to antiepileptic drugs and seizures, quality of life, and productivity: survey of patients with epilepsy and physicians. Epilepsy Behav. 2008; 13 (2): 316–22. https://doi.org/10.1016/j.yebeh.2008.03.009 PMid:18472303
World Health Organization. Epilepsy in the WHO Africa Region, Bridging the Gap: the Global Campaign Against Epilepsy. Out of Shadows. Geneva: WHO Press, 2004.
Barennes H, Duc-Si Tran, Latthaphasavang V, Preux PM, Odermatt P. Epilepsy in Lao PDR: From research to treatment intervention. Neurology Asia. 2008; 13: 27–31.
Bartolini E, Bell G, Sander JW. Multicultural challenges in epilepsy. Epilepsy and Behavoiur. 2011; 20: 428-34. https://doi.org/10.1016/j.yebeh.2010.12.045 PMid:21310665
Tang F, Zhu G, Jiao Z, Ma C, Wang B. The effects of medication education and behavioral intervention on Chinese patients with epilepsy. Epilepsy & Behavior. 2014; 37:157–64. https://doi.org/10.1016/j.yebeh.2014.05.017 PMid:25022824
Al aqeel S, Al-sabhan J, Hiligsmann M. Strategies for improving adherence to antiepileptic drug treatmentin people withepilepsy. Cochrane Database of Systematic Reviews. 2017; 2: CD008312. PMid:28157274
Demonceau J, Ruppar T, Kristanto P, et al. Identification and assessment of adherence enhancing interventions in studies assessing medication adherence through electronically compiled drug dosing histories: a systematic literature review and meta analysis. Drugs. 2013; 73:545–62. https://doi.org/10.1007/s40265-013-0041-3 PMid:23588595 PMCid:PMC3647098
Matthes J, Albus C. Improving adherence with medication: a selective literature review based on the example of hypertension treatment. Dtsch Arztebl Int. 2014; 111:41–7. https://doi.org/10.3238/arztebl.2014.0041
Kripalani S, Yao X, Haynes RB. Interventions to enhance medication adherence in chronic medical conditions: a systematic review. Arch Intern Med. 2007; 167: 540–50. https://doi.org/10.1001/archinte.167.6.540 PMid:17389285
Al Ajmi, R, Al Aqeel, S, Baz, S. The impact of pharmacist-led educational interview on medication adherence of Saudi patients with epilepsy. Patient Preference and Adherence. 2017; 11: 959-64. https://doi.org/10.2147/PPA.S124028 PMid:28572723 PMCid:PMC5441662
Jacoby A, Wang W, Vu TD, Wu J, Snape D, Aydemir N, Parr J.et al. Meanings of epilepsy in its sociocultural context and implications for stigma: findings from ethnographics studies in local communities in China and Vietnam. Epilepsy Behav. 2008; 12: 286-97. https://doi.org/10.1016/j.yebeh.2007.10.006 PMid:18032116
Hosseini N, Sharif F, Ahmadi F, Zare M. Striving for balance: coping with epilepsyin Iranian patients. Epilepsy Behav. 2010; 18: 466-71. https://doi.org/10.1016/j.yebeh.2010.05.022 PMid:20605112
Costa E, Giardini A, Savin M. Interventional tools to improve medication Adherence: review of literature. Patient Preference and Adherence. 2015; 9:1303-14. https://doi.org/10.2147/PPA.S87551 PMid:26396502 PMCid:PMC4576894
Tang F, Zhu G, Jiao Z, Ma C, Wang B. Self reported adherence inpatients with epilepsy who missed their medications and reasons for nonadherence in China. Epilepsy Behav. 2013; 27: 85–9. https://doi.org/10.1016/j.yebeh.2012.12.022 PMid:23399942
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