Obstetric Outcome in Pregnant Patients with Low Level of Pregnancy-Associated Plasma Protein A in First Trimester

Vesna Livrinova; Igor Petrov; Igor Samardziski; Viktorija Jovanovska; Slagjana Simeonova-Krstevska; Irena Todorovska; Aleksandra Atanasova-Boshku; Milena Gjorgjievska

doi:10.3889/oamjms.2018.238

Authors

Vesna Livrinova University Clinic for Obstetrics and Gynecology, Medical Faculty, Ss Cyril and Methodius University of Skopje, Skopje
Igor Petrov Universtity Clinic for Neurology, Medical Faculty, Ss Cyril and Methodius University of Skopje, Skopje
Igor Samardziski University Clinic for Obstetrics and Gynecology, Medical Faculty, Ss Cyril and Methodius University of Skopje, Skopje
Viktorija Jovanovska University Clinic for Obstetrics and Gynecology, Medical Faculty, Ss Cyril and Methodius University of Skopje, Skopje
Slagjana Simeonova-Krstevska University Clinic for Obstetrics and Gynecology, Medical Faculty, Ss Cyril and Methodius University of Skopje, Skopje
Irena Todorovska University Clinic for Obstetrics and Gynecology, Medical Faculty, Ss Cyril and Methodius University of Skopje, Skopje
Aleksandra Atanasova-Boshku University Clinic for Obstetrics and Gynecology, Medical Faculty, Ss Cyril and Methodius University of Skopje, Skopje
Milena Gjorgjievska University Clinic for Obstetrics and Gynecology, Medical Faculty, Ss Cyril and Methodius University of Skopje, Skopje

DOI:

https://doi.org/10.3889/oamjms.2018.238

Keywords:

Factor screening, First trimester, Pregnancy-associated plasma protein A, the Perinatal outcome

Abstract

BACKGROUND: Pregnancy-associated plasma protein A (PAPP-A), is a protease which releases Insulin-like growth factor. The role of this factor is stimulation of cell mitosis, differentiation and trophoblastic invasion of deciduas. Identification of patients with low PAPP-A (under 0.4 MoM in the first trimester has an influence on birth weight, attenuation of fetal growth, preeclampsia, birth and fetal demise.

AIM: The main issue in the study is evaluating an influence of PAPP-A, calculated in the first trimester on the unfavourable outcome of pregnancy.

MATERIAL AND METHODS: Seventy pregnant women with singleton pregnancy underwent first-trimester biochemical screening. The target group were women with PAPP-A below 0.4 MoM, and in control group, PAPP-A were Ð¾ver 0.4 MoM. There was an assessment of the influence on the mode of delivery, gestational week, the presence of intrauterine growth restriction, preeclampsia, temporary birth, intrauterine fetal demise and newborn condition.

RESULTS: In target group, consisted of 35 patients, 16 were delivered at term. From 28 to 37 g.w.- were 7 patient, 22-28 g.w.- 4 and 8 patients were under the 22 g.w (all with fetal demise) there were 19 pretemporary deliveries - 9 with Cesarean Section (SC). In the target group: 5 newborn wÐµre with IUGR, 6 women had preeclampsia, 1 had placental abruption. In control group were 35 patients: 28 delivered at term, 9 with SC, 26 vaginal deliveries; with IUGR were 4 newborns. Two newborns were hypertrophic.

CONCLUSION: There is a significant difference in unfavourable outcome in the cases with PAPP-A under 0.4 Mom, particular in the group, with a PAPP-A value under 0.2 MoM. The patients delivered with SC with the main indications in utero hypoxia, growth restriction and elevated blood pressure had PAPP-A between 0.3-0.4 MoM. The patients with intrauterine fetal death and placental abruption in the most of the cases have PAPP-A value under 0.2 MoM. There is a need to be aware in these pregnancies to achieve the preventions of adverse outcome, to decrease perinatal morbidity and mortality.

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Policy developed by: SA Maternal & Neonatal Community of Practice Approved SA Health Safety & Quality Strategic Governance Committee on: 19 April 2016 Management of women with a low PAPP-A and normal chromosomes. South Australian Perinatal Practice Guidelines, 2016.