Primary Cutaneous CD30+/ALK- ALCL with Transition into sALCL: Favourable Response after Systemic Administration with Brentuximab Vedotin! Unique Presentation in a Bulgarian Patient!

Authors

  • Tanya Naskova Popova Department of Clinical Hematology, University Multiprofile Hospital for Active Treatment “Sveti Ivan Rilski”, Sofia 15, Acad. Ivan Geshov Blvd., Sofia 1431
  • Atanass Radinov Department of Clinical Hematology, University Multiprofile Hospital for Active Treatment “Sveti Ivan Rilski”, Sofia 15, Acad. Ivan Geshov Blvd., Sofia 1431
  • Konstantin Stavrov Department of Dermatology, Venereology and Dermatologic Surgery, Medical Institute of Ministry of Interior (MVR-Sofia), General Skobelev 79, 1606 Sofia
  • Ivanka Temelkova Department of Dermatology, Venereology and Dermatologic Surgery, Medical Institute of Ministry of Interior (MVR-Sofia), General Skobelev 79, 1606 Sofia
  • Ivan Terziev Universitetska Mnogoprofilno Bolnitsa za Aktivno Lechenie "Tsaritsa Yoanna", Common and Clinical Pathology, Sofia
  • Ilia Lozev Medical Institute of the Ministry of Interior, Surgery, Sofia
  • Detelina Lukanova National Hospital of Cardiology, Clinic of Vascular surgery and Angiology, Sofia
  • Hristo Mangarov Department of Dermatology, Venereology and Dermatologic Surgery, Medical Institute of Ministry of Interior (MVR-Sofia), General Skobelev 79, 1606 Sofia
  • Uwe Wollina Städtisches Klinikum Dresden, Department of Dermatology and Allergology, Friedrichstrasse 41, Dresden
  • Georgi Tchernev Department of Dermatology, Venereology and Dermatologic Surgery, Medical Institute of Ministry of Interior (MVR-Sofia), General Skobelev 79, 1606 Sofia; Onkoderma, Policlinic for Dermatology and Dermatologic Surgery, General Skobelev 26, Sofia

DOI:

https://doi.org/10.3889/oamjms.2018.289

Keywords:

Anaplastic large, T cell lymphoma, Brentuximab, Remission, CD30

Abstract

BACKGROUND: Modern drugs could sometimes be a good solution even to problematic patients. The cutaneous and systemic forms of the CD30 positive anaplastic large T-cell lymphoma could often be described as a suitable target for therapy with Brentuximab vedotin.

CASE REPORT: We present the first case of a Bulgarian patient with a histologically confirmed primary cutaneous T-cell CD30+/ALK- large anaplastic cell lymphoma-cALCL (therapeutically resistant to therapy with Methotrexate, radiation therapy and systemic corticosteroid therapy) who was successfully treated with Brentuximab vedotin. In several years, the patient has developed a comparatively fast skin progression as well as an initial systemic one which impacts inguinal and mediastinal nodes. After the implementation of 4 therapy cycles with Brentuximab vedotin, complete regression of the described by previous hospitalisations lymph nodes as well as 80% reduction of the cutaneous and subcutaneous located tumour formations were observed.

CONCLUSION: The therapy of CD30+/ALK- anaplastic large T-cell lymphoma is a significant challenge for oncologists and dermatologists because it requires maximally efficient and minimally traumatic treatment in parallel. Therapy with Brentuximab is a new direction which shows extremely good clinical results and can be applied to the cutaneous as well as to the systemic form of anaplastic large-cell CD30 positive lymphoma. The key element by treatment with Brentuximab is suppression of the CD30- expression which, in turn, could be the cause of relapses. On that ground, patients with these lymphomas should be strictly monitored.

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References

Prince HM, Kim YH, Horwitz SM, Dummer R, Scarisbrick J, Quaglino P, Zinzani PL, Wolter P, Sanches JA, Ortiz-Romero PL, Akilov OE. Brentuximab vedotin or physician's choice in CD30-positive cutaneous T-cell lymphoma (ALCANZA): an international, open-label, randomised, phase 3, multicentre trial. The Lancet. 2017; 390(10094):555-66. https://doi.org/10.1016/S0140-6736(17)31266-7

Xing X, Feldman AL. Anaplastic large cell lymphomas: ALK positive, ALK negative, and primary cutaneous. Advances in anatomic pathology. 2015; 22(1):29-49. https://doi.org/10.1097/PAP.0000000000000047 PMid:25461779

Koh Y. Extended use of brentuximab vedotin before autologous stemâ€cell transplantation would benefit refractory systemic anaplastic largeâ€cell lymphoma. Clinical case reports. 2018; 6(5):798-801. https://doi.org/10.1002/ccr3.1461 PMid:29744059 PMCid:PMC5930222

Aguiar-Bujanda D, Due-as-Comino A, Cabello C, Bastida J, Rivero-Vera JC, Limeres-González MA. Early and sustained remission with brentuximab vedotin in a case of disseminated cutaneous relapse from systemic anaplastic large cell lymphoma refractory to chemotherapy. European Journal of Dermatology. 2017; 27(6):671-3. PMid:29165301

Oregel KZ, Everett E, Zhang X, Nagaraj G. Complete response in a critically ill patient with ALK-negative anaplastic large cell lymphoma treated with single agent brentuximab-vedotin. Expert review of anticancer therapy. 2016; 16(3):279-83. https://doi.org/10.1586/14737140.2016.1146597 PMid:26809026

Colton Nielson BS, Ryan Fischer MD, Garth Fraga MD. Loss of CD30 expression in anaplastic large cell lymphoma following brentuximab therapy. J Drugs Dermatol. 2016; 15(7):894-5. PMid:27391642

Published

2018-07-12

How to Cite

1.
Popova TN, Radinov A, Stavrov K, Temelkova I, Terziev I, Lozev I, Lukanova D, Mangarov H, Wollina U, Tchernev G. Primary Cutaneous CD30+/ALK- ALCL with Transition into sALCL: Favourable Response after Systemic Administration with Brentuximab Vedotin! Unique Presentation in a Bulgarian Patient!. Open Access Maced J Med Sci [Internet]. 2018 Jul. 12 [cited 2024 Mar. 29];6(7):1275-7. Available from: https://oamjms.eu/index.php/mjms/article/view/oamjms.2018.289

Issue

Section

C- Case Reports

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