Assessment of Expression of Ki-67 in Benign and Malignant Prostatic Lesions among Sudanese Patients

Authors

  • Albasheer Abdelmalik Mohamed Department of Histopathology and cytology, College of Medical Laboratory Sciences, University of Science and Technology, Omdurman
  • Mohammed Yousif Abbas Allied Health Department - Medical Laboratory Sciences, College of Health Sciences, University of Bahrain
  • Hajed Alharbi Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University
  • Ali Yousif Babiker Department of Histopathology and cytology, College of Medical Laboratory Sciences, University of Science and Technology, Omdurman, Sudan; Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University

DOI:

https://doi.org/10.3889/oamjms.2018.309

Keywords:

Prostatic cancer, Ki-67, Sudanese patients, Prostatic lesions

Abstract

BACKGROUND: Prostatic cancer is one of the most common cancers of males in a Sudanese population. The early detection is very important, as it is only curable at an early stage.

AIM: The objective of this study was to investigate the expression pattern of Ki-67 in benign and malignant prostatic lesions to improve the diagnosis that may help in better management and prevention of disease.

MATERIAL AND METHODS: Fifty-eight formalin fixed paraffin blocks from diagnosed cases of prostatic tumours with different grade, and stages were included in this study. Ki-67 expression was examined immunohistochemically by using monoclonal mouse anti-human Ki67 IS626. The results were correlated with Gleason score and tumour differentiation and stage.

RESULTS: The frequency of histological types was as follow: 11 cases of benign prostate,atic hyperplasia (19%) and 47 cases of prostatic cancer (81%). Our results stated that prostatic adenocarcinoma among Sudanese patients was of low grade which means tumours are less aggressive. Furthermore, the findings demonstrate that Ki-67 expression in prostatic carcinoma smears was correlated significantly with the degree of Gleason score (P < 0.05).

CONCLUSIONS: We found that the prostatic adenocarcinoma among Sudanese patients was less aggressive. Furthermore, Ki-67 expression was proportional to the grade of a tumour and it was a useful prognostic and diagnostic biomarker.

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Published

2018-09-26

How to Cite

1.
Mohamed AA, Abbas MY, Alharbi H, Babiker AY. Assessment of Expression of Ki-67 in Benign and Malignant Prostatic Lesions among Sudanese Patients. Open Access Maced J Med Sci [Internet]. 2018 Sep. 26 [cited 2021 Apr. 12];6(10):1809-12. Available from: https://oamjms.eu/index.php/mjms/article/view/oamjms.2018.309

Issue

Section

A - Basic Science

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