Assessment of Expression of Ki-67 in Benign and Malignant Prostatic Lesions among Sudanese Patients

Albasheer Abdelmalik Mohamed; Mohammed Yousif Abbas; Hajed Alharbi; Ali Yousif Babiker

doi:10.3889/oamjms.2018.309

Authors

Albasheer Abdelmalik Mohamed Department of Histopathology and cytology, College of Medical Laboratory Sciences, University of Science and Technology, Omdurman
Mohammed Yousif Abbas Allied Health Department - Medical Laboratory Sciences, College of Health Sciences, University of Bahrain
Hajed Alharbi Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University
Ali Yousif Babiker Department of Histopathology and cytology, College of Medical Laboratory Sciences, University of Science and Technology, Omdurman, Sudan; Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University

DOI:

https://doi.org/10.3889/oamjms.2018.309

Keywords:

Prostatic cancer, Ki-67, Sudanese patients, Prostatic lesions

Abstract

BACKGROUND: Prostatic cancer is one of the most common cancers of males in a Sudanese population. The early detection is very important, as it is only curable at an early stage.

AIM: The objective of this study was to investigate the expression pattern of Ki-67 in benign and malignant prostatic lesions to improve the diagnosis that may help in better management and prevention of disease.

MATERIAL AND METHODS: Fifty-eight formalin fixed paraffin blocks from diagnosed cases of prostatic tumours with different grade, and stages were included in this study. Ki-67 expression was examined immunohistochemically by using monoclonal mouse anti-human Ki67 IS626. The results were correlated with Gleason score and tumour differentiation and stage.

RESULTS: The frequency of histological types was as follow: 11 cases of benign prostate,atic hyperplasia (19%) and 47 cases of prostatic cancer (81%). Our results stated that prostatic adenocarcinoma among Sudanese patients was of low grade which means tumours are less aggressive. Furthermore, the findings demonstrate that Ki-67 expression in prostatic carcinoma smears was correlated significantly with the degree of Gleason score (P < 0.05).

CONCLUSIONS: We found that the prostatic adenocarcinoma among Sudanese patients was less aggressive. Furthermore, Ki-67 expression was proportional to the grade of a tumour and it was a useful prognostic and diagnostic biomarker.