Comparison of the Effects of Omega 3 and Vitamin E on Palcitaxel-Induced Peripheral Neuropathy

Authors

  • Ali Arash Anoushirvani Department of Hematology and Medical Oncology, Arak University of Medical Sciences, Arak
  • Laila Poorsaadat Department of Neurology, Arak University of Medical Sciences, Arak
  • Reza Aghabozorgi Department of Hematology and Medical Oncology, Arak University of Medical Sciences, Arak
  • Maryam Kasravi Department of Internal Medicine, Arak University of Medical Sciences, Arak

DOI:

https://doi.org/10.3889/oamjms.2018.333

Keywords:

Neuropathy, Omega 3, Paclitaxel, Vitamin E

Abstract

BACKGROUND: Paclitaxel-induced peripheral neuropathy is the most important side effect limiting the use of this medication.

AIM: This study aimed to compare the effects of omega-3 and vitamin E on the incidence of peripheral neuropathy in patients receiving Taxol.

METHODS: In this clinical trial, 63 patients who were a candidate for receiving taxol, were enrolled based on inclusion and exclusion criteria. In group O, patients received 640 mg omega-3 three times a day, and group E, received 300 mg vitamin E two times a day. Patients took the supplements up to three months after the onset of Taxol. Group P received placebo for a similar period. All patients referred to a neurologist for electrophysiological evaluation before the onset of chemotherapy and at months 1 and 3. The presence of neuropathy and its progression was recorded by the neurologist.

RESULTS: Neurological examination in this study indicated that 6 patients (28.6%) in Group O, 7 patients (33.3%) in group E, and 15 patients (71.4%) in placebo group started peripheral neuropathy. There was a significant difference between intervention groups and the placebo group (p = 0.0001) and no significant difference between intervention groups (p = 0.751).

CONCLUSION: Our data suggested that vitamin E and omega-3 may significantly reduce the incidence of Paclitaxel-induced peripheral neuropathy. Routine administration of such supplements that have no special side effect for patients under chemotherapy may greatly enhance their quality of life.

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Published

2018-10-21

How to Cite

1.
Anoushirvani AA, Poorsaadat L, Aghabozorgi R, Kasravi M. Comparison of the Effects of Omega 3 and Vitamin E on Palcitaxel-Induced Peripheral Neuropathy. Open Access Maced J Med Sci [Internet]. 2018 Oct. 21 [cited 2021 Apr. 12];6(10):1857-61. Available from: https://oamjms.eu/index.php/mjms/article/view/oamjms.2018.333

Issue

Section

B - Clinical Sciences

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