Mercury Materno-fetal Burden and Its Nutritional Impact

Authors

  • Enas R. Abdel Hameed Child Health Department, Medical Research Division, National Research Center, Cairo
  • Lobna S. Sherif Child Health Department, Medical Research Division, National Research Center, Cairo
  • Ola M. Abdel Samie Child Health Department, Medical Research Division, National Research Center, Cairo
  • Hanaa H. Ahmed Hormones Department, Medical Research Division, National Research Center, Cairo
  • Amira Ahmed El-Galaa Teaching Hospital, Cairo
  • Hala Atta El-Galaa Teaching Hospital, Cairo
  • Hisham Waheed Child Health Department, Medical Research Division, National Research Center, Cairo
  • Reham F. Fahmy Child Health Department, Medical Research Division, National Research Center, Cairo http://orcid.org/0000-0002-2095-0148

DOI:

https://doi.org/10.3889/oamjms.2018.364

Keywords:

mercury, pregnancy, cord blood, nutrition

Abstract

BACKGROUND: Mercury exists worldwide in food, water and air throwing its health hazards on all body systems.

AIM: To show the influence of the presence of mercury in pregnant mothers’ blood on its level in the umbilical cord blood; and to display the relationship between the different foodstuff on the mercury levels in pregnant mothers' and umbilical cord blood.

PATIENTS AND METHODS: This cross-sectional study was conducted on randomly chosen 113 pregnant mothers at the time of labour and on their newborns. Full history, sociodemographic data and food frequency questionnaire for dietary assessment were recorded. The Maternal and neonatal anthropometric measurements together with the Apgar scoring were also measured. Serum mercury levels in both mothers' and umbilical cord blood were measured using the Inductively Coupled Plasma Mass Spectrometry (ICP-MS).

RESULTS: A high percentage of mothers (82.3%) were exposed to passive smoking. There was a statistically significant positive correlation between the maternal and fetal umbilical cord blood mercury levels (p = 0.002). There was an insignificant negative correlation between the maternal blood and fetal umbilical cord blood mercury levels on one side and each of the different foodstuff on the other side (fish, vegetables, fruits and proteins, for example, meat and legumes). An insignificant positive correlation was found between dairy products and of the maternal blood and umbilical cord blood mercury levels.

CONCLUSION: The fetal umbilical cord blood mercury levels correlate positively with the maternal blood mercury. The different foodstuff can influence the maternal and umbilical cord blood mercury levels whether by increase or decrease. Strict measures should be taken to decrease environmental mercury contamination with attention to pregnant mothers.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Plum Analytics Artifact Widget Block

References

Solenkova NV, Newman JD, Berger JS, et al. Metal pollutants and cardiovascular disease: Mechanism and Consequences of Exposure. Am Heart J. 2014; 158(6):812-822. https://doi.org/10.1016/j.ahj.2014.07.007 PMid:25458643 PMCid:PMC4254412

Agency for Toxic Substances and Disease Registry (ATSDR). The priority list of hazardous substances. Atlanta (GA): U.S. Department of Health and Human Services, Public Health Service, 2011.

Rice KM, Walker EM, WM, Gillette C, et al. Environmental Mercury and Its toxic Effects. J Prev Med Public Health. 2014; 47(2):74-83. https://doi.org/10.3961/jpmph.2014.47.2.74 PMid:24744824 PMCid:PMC3988285

Yoshida M. Placental to fetal transfer of mercury and fetotoxicity. Tohoku J Exp Med. 2002; 196(2):79-88. https://doi.org/10.1620/tjem.196.79 PMid:12498319

Li SJ, Zhang SH, Chen HP, et al. Mercury-induced membranous nephropathy: clinical and pathological features. Clin J Am Soc Nephrol. 2010; 5(3)439-444. https://doi.org/10.2215/CJN.07571009 PMid:20089494 PMCid:PMC2827581

Minoia C, Ronchi A, Pigatto P, Guzzi J. Effects of mercury on the endocrine system. Crit Rev Toxicol. 2009; 39-(6):538.

Pyszel A, Wrobel T, Szuba A, Andrzejak R. Effects of metals, benzene, pesticides and ethylene oxide on the haematopoietic system. Med Pr. 2005; 56(3):249-255. PMid:16218139

World Health Organization. Physical status: the use and interpretation of anthropometry. Report of a WHO Expert Committee. Technical report series no. 854: Geneva: World Health Organization, 1995.

Apgar V, Holaday DA, James LS, Weisbrot IM, Berrien C. Evaluation of the newborn infant; second report. J Am Med Assoc. 1958; 168:1985-1988. https://doi.org/10.1001/jama.1958.03000150027007 PMid:13598635

World Health Organization. WHO child growth standards: length/height for age, weight-for-age, weight-for-length, weight-for-height and body mass index-for-age, methods and development. World Health Organization, 2006.

Metwally FM, Abdelraoof ER, Rashad H, Hasheesh A, et al. Toxic effect of some heavy metals in Egyptian autistic children. IJPCR. 2015; 7(3):X.

Amadi CN, Igweze ZN, Orisakwe OE. Heavy metals in miscarriage and stillbirths in developing nations. Middle East Fertility Society Journal. 2017; 22(2):91-100. https://doi.org/10.1016/j.mefs.2017.03.003

Rahman A, Kumararthasan P, Gomes J. Infant and mother related outcomes from exposure to metals with endocrine disrupting properties during pregnancy. Sci Total Environ. 2016; 569-570:1022-1031. https://doi.org/10.1016/j.scitotenv.2016.06.134 PMid:27378155

Pirard C, Koppen G, De Cremer K, et al. Hair mercury and urinary cadmium levels in Belgian children and their mothers within the framework of the COPHES/ DEMOCOPHES projects. Sci Total Environ. 2014; 472:730-740. https://doi.org/10.1016/j.scitotenv.2013.11.028 PMid:24333995

Corvelo TC, Oliveira EA, Parijos AM, et al. Monitoring mercury exposure in reproductive aged women inhabiting the Tapajos river basin. Bull Environ Contam Toxicol. 2014; 93:42- 46. https://doi.org/10.1007/s00128-014-1279-5 PMid:24789525

Gundacker C, Hengstschlager M. The role of the placenta in Fetal exposure to heavy metals. Wien. Med. Wochenschr. 2012; 162:201-206. https://doi.org/10.1007/s10354-012-0074-3 PMid:22717874

Nakal K, Suzuki K, Oka T, Murata K, et al. The Tohoku study of child Development. A Cohort study of Effects of Perinatal Exposures to Methylmercury and Environmentally Persistent Organic Pollutants on Neurobehavioral Development in Japanese Children. Tohoku J Exp Med. 2004; 202:227-237. https://doi.org/10.1620/tjem.202.227

Needham LL, Grandjean P, Heinzow B, Jorgensen PJ, et al. Partition of environmental chemicals between maternal and fetal blood and tissues. Environ Sci Technol. 2011; 45:1121-1126. https://doi.org/10.1021/es1019614 PMid:21166449 PMCid:PMC3031182

Unuvar E, Ahmadov H, Kiziler AR, Ark C. Mercury levels in cord blood and meconium of healthy newborns and venous blood of their mothers: Clinical, prospective cohort study. Science of the total Environment. 2007; 374(1):60-70. https://doi.org/10.1016/j.scitotenv.2006.11.043 PMid:17258795

Lindbohm ML, Sallmen M. Reproductive effects caused by chemical and biological agents. Finnish Institute of Occupational Health, 2017. PMid:28739833

Huang SH, Weng KP, Ger LP, Liou HH, Lin CC, et al. Influence of seafood and vitamin supplementation on maternal and umbilical cord blood mercury concentration. Journal of the Chinese Medical Association. 2017; 80(5):307-312. https://doi.org/10.1016/j.jcma.2016.11.005 PMid:28262384

Thomas S, Arbuckle TE, Fisher M, Fraser WD, et al. Metals poseur and risk of small for- gestational age birth in a Canadian birth cohort: The MIREC study. Environmental Research. 2015; 141:430-439. https://doi.org/10.1016/j.envres.2015.04.018 PMid:25967284

Jinhua Wu, Ying T, Shen Z, et al. Effect of Low-Level Prenatal Mercury Exposure on Neonate Neurobehavioral Development in China Pediatric Neurology. 2014; 51(1):93-99. PMid:24938141

Garcia-Esquinas E, Perez-Gomez B, Fernandez-Navarro P, et al. Lead, mercury and cadmium in umbilical cord blood and its association with parental epidemiological variables and birth factors. BMC Public Health. 2013; 13:841. https://doi.org/10.1186/1471-2458-13-841 PMid:24028648 PMCid:PMC3848449

Hsu CS, Liu PL, Chien LC, Chou SY, Han BC. Mercury concentration and Fish consumption in Taiwanese pregnant women. BJOG. 2007; 114:81-85. https://doi.org/10.1111/j.1471-0528.2006.01142.x PMid:17081179

Bernhard D, Rossmann A, Wick G. Metals in Cigarette smoke. IUBMB Life. 2005; 57(12):805-809. https://doi.org/10.1080/15216540500459667 PMid:16393783

Kowalski R, Wiercinski J. Mercury content in smoke and tobacco from selected cigarette brands. Ecological Chemistry and Engineering. 2009; 16(52).

Kafai MR, Ganji V. Sex, age geographical location, smoking and alcohol consumption influence serum selenium concentrations in the USA. J Trace Elem Med Biol. 2003; 17(1)13-18. https://doi.org/10.1016/S0946-672X(03)80040-8

Huang SH, Weng KP, Lin CC, Wang CC, Lee CTC, et al. Maternal and umbilical cord blood levels of mercury, manganese, iron and copper in southern Taiwan. Across-sectional study Journal of the Chinese Medical Association. 2017; 80(7):442-451. https://doi.org/10.1016/j.jcma.2016.06.007 PMid:27889462

Kopp RS, Kumbartski M, Harth V, Bruning T, Kafferlein HU. Partition of metals in the maternal / fetal unit and lead associated decreases of fetal iron and manganese: an observational biomonitoring approach. Arch Toxicol. 2012 86:1571-1581. https://doi.org/10.1007/s00204-012-0869-4 PMid:22678741

Rudge CV, Rollin HB, Nogueira CM, Thomassem Y, et al. The placenta as a barrier for toxic and essential elements in paired maternal and cord blood samples of South African delivering women. J Environ Monit. 2009; 11:1322-1330. https://doi.org/10.1039/b903805a PMid:20449220

Butler Walker J, Houseman J, Seddon L, McMullen E, et al. Maternal and umbilical cord blood levels of mercury, lead, cadmium and essential trace elements in Arctic Canada. Environ Res. 2006; 100:295-318. https://doi.org/10.1016/j.envres.2005.05.006 PMid:16081062

Hibbeln JR, Davis JM, Steer C, et al. Maternal seafood consumption in pregnancy and neurodevelopmental outcomes in childhood (ALSPAC study) an observational cohort study. Lancet. 2007; 369:578-585. https://doi.org/10.1016/S0140-6736(07)60277-3

Holland IB, Smith L, Saaremk et al. Maternal supplementation with very-long-chain n-3 fatty acids during pregnancy and lactation augments children's IQ at 4 years of age. Pediatrics. 2003; 111:e39-e44. https://doi.org/10.1542/peds.111.1.e39

Rahbar MH, Samms-Vaughan M, Dickerson AS, Hessabi M, et al. Concentration of lead, Mercury, Cadmium, Aluminum, Arsenic and Manganese in umbilical cord blood of Jamaican newborns. Int J Environ Res Public Health. 2015; 12:4481-4501. https://doi.org/10.3390/ijerph120504481 PMid:25915835 PMCid:PMC4454921

Taryk ME, Bhavsar SP, Bowerman W, et al. Risks and benefits of consumption of great lakes fish. Environ Health Perspect. 2012; 120:11-18. https://doi.org/10.1289/ehp.1003396 PMid:21947562 PMCid:PMC3261933

Dang, Wang WX. Antagonistic interaction of mercury and selenium in a marine fish is dependent on their chemical species. Environ Sci Technol. 2011; 45(7):3116-3122. https://doi.org/10.1021/es103705a PMid:21366307

Ramon R, Ballester F, Aguinagalde X, et al. Fish consumption during pregnancy, prenatal mercury exposure and anthropometric measures at birth in a prospective mother-infant cohort study in Spain. Am J Xlin Nutr. 2009; 90:1047-1055. https://doi.org/10.3945/ajcn.2009.27944 PMid:19710189

Mozaffarian D. Fish, mercury, selenium and cardiovascular risk: Current evidence and unanswered questions. Int J Environ Res Public Health. 2009; 6:1894-1916. https://doi.org/10.3390/ijerph6061894 PMid:19578467 PMCid:PMC2705224

Yi Y, Tang C, Yi T, et al. Health risk assessment of heavy, metals in fish and accumulation patterns in food web in the upper Yangtze River, China. Ecotoxicol Environ Saf. 2017; 145:295-302. https://doi.org/10.1016/j.ecoenv.2017.07.022 PMid:28755647

Wei Y, Zhang J, Zhang D, et al. Metal concentrations in various fish organs of different fish species from Poyang lake, china. Ecotoxicol Environ Saf. 2014; 104:182-188. https://doi.org/10.1016/j.ecoenv.2014.03.001 PMid:24681447

Sharma A, Flora SJS. Nutritional management can assist a significant role in alleviation of arsenicosis. Journal of Trace Elements in Medicine and Biology. 2018; 45:11-20. https://doi.org/10.1016/j.jtemb.2017.09.010 PMid:29173466

Rezeai M, Dastjerdi HA, Jafaritt, et al. Assessment of dairy products consumed on the Arak market as determined by heavy metal residues. Health. 2014; 6(5):323-327. https://doi.org/10.4236/health.2014.65047

Meshref A, Moselhy W, Hassan N. Heavy metals and trace elements levels in milk and milk products. Journal of Food Measurement and Characterization. 2014; 8:381-388. https://doi.org/10.1007/s11694-014-9203-6

Abdulkhaliq A, Swaileh KH, Hassein RM, Matani M. Levels of metals (Ca, Pb, Cu and Fe) in cow's milk, dairy products and hen's eggs from the West Bank, Palestine. International Food Research Journal. 2012; 19(3):1089-1094.

Anastasion A, Caggiano R, Macchiato M, et al. Heavy metal concentrations in dairy products from sheep milk collected in two regions of Southern Italy. Acta Vet Scand. 2006; 47(1):69-74. https://doi.org/10.1186/1751-0147-47-69 PMCid:PMC1698924

Published

2018-09-24

How to Cite

1.
Abdel Hameed ER, Sherif LS, Abdel Samie OM, Ahmed HH, Ahmed A, Atta H, Waheed H, Fahmy RF. Mercury Materno-fetal Burden and Its Nutritional Impact. Open Access Maced J Med Sci [Internet]. 2018 Sep. 24 [cited 2024 May 26];6(9):1652-8. Available from: https://oamjms.eu/index.php/mjms/article/view/oamjms.2018.364

Issue

Section

B - Clinical Sciences

Most read articles by the same author(s)

1 2 > >>