EBV Positive Gastric Carcinomas and Their Clinicopathological Characteristics

Authors

  • Ljubomir Ognjenovikj University Clinic for Abdominal Surgery, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, Skopje
  • Aleksandar Shumkovski University Clinic for Abdominal Surgery, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, Skopje
  • Stojan Gjoshev University Clinic for Abdominal Surgery, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, Skopje
  • Goce Volchevski University Clinic for Abdominal Surgery, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, Skopje
  • Gjorgji Trajkovski University Clinic for Abdominal Surgery, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, Skopje
  • Zoran Karadzov University Clinic for Abdominal Surgery, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, Skopje
  • Darko Dzambaz University Clinic for Abdominal Surgery, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, Skopje
  • Dragan Hadzi-Manchev University Clinic for Abdominal Surgery, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, Skopje
  • Todor Hadzi-Manchev University Clinic for Abdominal Surgery, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, Skopje
  • Gordana Petrushevska Institute of Pathology, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, Skopje
  • Vesna Janevska Institute of Pathology, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, Skopje
  • Vlado Janevski University Clinic for Abdominal Surgery, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, Skopje
  • Nikola Brzanov Univeristy Clinic for TOARILUC, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, Skopje

DOI:

https://doi.org/10.3889/oamjms.2018.409

Keywords:

EBV, gastric carcinoma, immunohistochemistry, clinicopathological characteristics

Abstract

BACKGROUND: The understanding of the etiopathogenesis of gastric carcinoma (GC) can be a base for development of new therapeutic methods to reduce mortality and to increase survival in patients with GC. The percentage of Epstein - Barr virus (EBV) positive gastric carcinomas is uncertain, and the etiologic importance of EBV in the pathogenesis of GC has still not been elucidated.

AIM: This study aimed to determine the percentage of EBV associated GC as well as to determine their clinicopathological characteristics.

MATERIAL AND METHODS: The study included 80 patients with GC who were analysed for ethnicity, local growth of a tumour (T status), the presence of nodal metastases (N), the presence of distant metastases (M), stage of the disease and degree of carcinoma differentiation. For detection of EBV, immunostainings were performed on tumour tissue and the peripheral non-tumour gastric mucosa.

RESULTS: Positive immunostaining with an antibody against EBV was found in 19 (23.75%) of the 80 patients with gastric carcinomas. EBV immunostainings were significantly different in patients with or without metastasis and between patients of Macedonian and Albanian ethnicity (p < 0.0001, p < 0.009, respectively). EBV immunoexpression was significantly associated with the presence of distant metastases and with patients of Albanian ethnicity.

CONCLUSION: Association of EBV immunostainings with distant metastasis in patients with GC suggests the influence of EBV infection on the progression of gastric carcinoma. Due to scarce and doubtful literature data on EBV associated GC, further studies are necessary to determine the role of EBV regarding aetiology, treatment and prognosis in patients with EBV associated gastric carcinoma.

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References

Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002.CA Cancer J Clin. 2005; 55:74–108. https://doi.org/10.3322/canjclin.55.2.74 PMid:15761078

Jemal A, Bray F, Center MM, et al. Global cancer statistics. CA Cancer J Clin. 2011; 61:69 90. https://doi.org/10.3322/caac.20107 PMid:21296855

Cunningham D, Allum WH, Stenning SP, et al. Perioperative chemotherapy versussurgery alone for resectable gastroesophageal cancer. New Eng J Med. 2006; 355(1):11–22. https://doi.org/10.1056/NEJMoa055531 PMid:16822992

Macdonald JS, Smalley SR, Benedetti J, et al. Chemoradiotherapy after surgerycompared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction. N Eng J Med. 2001; 345(10):725–730. https://doi.org/10.1056/NEJMoa010187 PMid:11547741

Murphy G, Pfeiffer R,Constanza Camargo CM, Rabkin C.Meta-analysis Shows That Prevalence of Epstein–Barr Virus-Positive Gastric Cancer Differs Based on Sex and Anatomic Location. Ggastroenterology. 2009; 137:824–833. https://doi.org/10.1053/j.gastro.2009.05.001 PMid:19445939 PMCid:PMC3513767

Truong CD, Feng W, Li W, Khoury T, Li Q, Alrawi S, Yu Y, Xie K, Yao J, Tan D. Characteristics of Epstein-Barr virus-associated gastric cancer: a study of 235 cases at a comprehensive cancer center in U.S.A. Exp Clin Cancer Res. 2009; 28:14. https://doi.org/10.1186/1756-9966-28-14 PMid:19192297 PMCid:PMC2642773

Kim Y, Shin A, Gwack J, Ko KP, Kim CS, Park SK, Hong YC, Kang D, Yoo KY. Epstein-Barr virus antibody level and gastric cancer risk in Korea: a nested case-control study. Br J Cancer. 2009; 101(3):526-9. https://doi.org/10.1038/sj.bjc.6605146 PMid:19550421 PMCid:PMC2720236

Tokunaga M, Land CE. Epstein-Barr virus involvement in gastric cancer: biomarker for lymph node metastasis. Cancer Epidemiol Biomarkers. 1998; 7:449–450.

Takada K. Epstein-Barr virus and gastric carcinoma. Mol Pathol. 2000; 53:255–61. https://doi.org/10.1136/mp.53.5.255 PMid:11091849 PMCid:PMC1186978

Fukayama M, Hayashi Y, Iwasaki Y, et al. Epstein-Barr virus associated gastric carcinoma and Epstein-Barr virus infection of the stomach. Lab Invest. 1994; 71:73–81. PMid:8041121

Burgess DE, Woodman CB, Flavell KJ, et al. Low prevalence of Epstein-Barr virus in incident gastric adenocarcinomas from the United Kingdom. Br J Cancer. 2002; 86:702–4. https://doi.org/10.1038/sj.bjc.6600107 PMid:11875729 PMCid:PMC2375309

Wang HH, Wu MS, Shun CT, et al. Lymphoepithelioma-like carcinoma of the stomach: a subset of gastric carcinoma with distinct clinicopathological features and high prevalence of Epstein-Barr virus infection. Hepatogastroenterol. 1999; 46:1214–9.

Herrera-Goepfert R, Akiba S, Koriyama C, Ding S, Reyes E, Itoh T, Minakami Y, Eizuru Y. Epstein-Barr virus-associated gastric carcinoma: Evidence of age-dependence among a Mexican population. World J Gastroenterol. 2005; 11(39):6096-103. https://doi.org/10.3748/wjg.v11.i39.6096 PMid:16273633 PMCid:PMC4436624

Lee JH, Kim SH, Han SH, An JS, Lee ES, Kim YS. Clinicopathological and Molecular Characteristics of Epstein-Barr Virus-associated Gastric Carcinoma: A Meta-analysis. J Gastroenterol Hepatol. 2009; 24(3):354-65. https://doi.org/10.1111/j.1440-1746.2009.05775.x PMid:19335785

Published

2018-10-12

How to Cite

1.
Ognjenovikj L, Shumkovski A, Gjoshev S, Volchevski G, Trajkovski G, Karadzov Z, Dzambaz D, Hadzi-Manchev D, Hadzi-Manchev T, Petrushevska G, Janevska V, Janevski V, Brzanov N. EBV Positive Gastric Carcinomas and Their Clinicopathological Characteristics. Open Access Maced J Med Sci [Internet]. 2018 Oct. 12 [cited 2021 Apr. 12];6(10):1829-32. Available from: https://oamjms.eu/index.php/mjms/article/view/oamjms.2018.409

Issue

Section

B - Clinical Sciences

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