The Effects of Filgrastim on Complications of Patients with Cerebral Hemorrhage Due To Head Trauma

Morteza Qaribi; Arash Yazdanbakhsh; Koorosh Ahmadi; Mohammad Reza Maghsoudi; Vagefe Farshin; Ali Ahmadi; Abolfazl Jokar

doi:10.3889/oamjms.2018.412

Authors

Morteza Qaribi Department of Emergency Medicine, Arak University of Medical Sciences, Arak
Arash Yazdanbakhsh Department of Emergency Medicine, Arak University of Medical Sciences, Arak
Koorosh Ahmadi Department of Emergency Medicine, Alborz University of Medical Sciences, Karaj
Mohammad Reza Maghsoudi Department of Emergency Medicine, Alborz University of Medical Sciences, Karaj
Vagefe Farshin Department of Emergency Medicine, Arak University of Medical Sciences, Arak
Ali Ahmadi Iran University of Medical Sciences
Abolfazl Jokar Department of Emergency Medicine, Arak University of Medical Sciences, Arak

DOI:

https://doi.org/10.3889/oamjms.2018.412

Keywords:

Filgrastim, Brain Trauma, Complications

Abstract

BACKGROUND: Filgrastim, a neopogen brand, is a blood-forming agent and a natural protein in the body that plays a role in stimulating the growth of white blood cells and protecting them against infectious agents. To the best of knowledge, human and animal specimens have shown the effect of Filgrastim on treating brain injuries regarding bone marrow transfusion into the blood, neuroprotection, stimulation of neurons for forming new neural networks and reducing the risk of bacterial infections.

AIM: This study aimed to investigate the effect of Filgrastim on the prognosis of a cerebral haemorrhage in patients with traumatic brain injury.

METHODS: This study was conducted as a clinical trial, in which the initial diagnosis of patients with cerebral haemorrhage due to head trauma was performed with a clinical examination and CT scan. After the patient arrives at the emergency room, the patient's initial examination is performed, and blood tests are taken from the patient. Moreover, CBC values (Hb, Platelet, Hematocrit) were checked and recorded in the checklist. The intervention group received 150 mcg/day Filgrastim injected subcutaneously for 4 days. Furthermore, patients in the control group received the same amount of sterile water. At the end of the treatment period, blood tests were performed again in all patients, and their results were then recorded. All data were analysed by SPSS v.21 software package.

RESULTS: Our findings revealed that the mean volume of bleeding in the intervention group based on CT scan was significantly reduced after four days as compared to the control group. Moreover, the mean score of consciousness and muscular strength of patients in the intervention group was significantly higher than the control group. Also, WBCs in the intervention group exhibited a significant increase after four days of intervention, while platelet and hematocrit levels in the intervention group decreased significantly compared to the control group.

CONCLUSION: Regarding the results, the therapeutic application of filtration is considered to be effective. Given the lack of serious complications of the proposed dosages, the use of this drug can be suggested.

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