Efficacy of Azole Antifungal in Treatment of Pityriasis Versicolor

Van Tran Cam; Thuong Nguyen Van; Khang Tran Hau; Doanh Le Huu; Phuong Pham Thi Minh; Sau Nguyen Huu; Thu Nguyen Minh; Marco Gandolfi; Francesca Satolli; Claudio Feliciani; Micheal Tirant; Aleksandra Vojvodic; Torello Lotti

doi:10.3889/oamjms.2019.092

Authors

Van Tran Cam National Hospital of Dermatology and Venereology, Hanoi, Vietnam
Thuong Nguyen Van National Hospital of Dermatology and Venereology, Hanoi, Vietnam
Khang Tran Hau National Hospital of Dermatology and Venereology, Hanoi, Vietnam
Doanh Le Huu National Hospital of Dermatology and Venereology, Hanoi, Vietnam
Phuong Pham Thi Minh National Hospital of Dermatology and Venereology, Hanoi, Vietnam
Sau Nguyen Huu National Hospital of Dermatology and Venereology, Hanoi, Vietnam
Thu Nguyen Minh National Hospital of Dermatology and Venereology, Hanoi, Vietnam
Marco Gandolfi Unit of Dermatology, University of Parma, Parma, Italy
Francesca Satolli Unit of Dermatology, University of Parma, Parma, Italy
Claudio Feliciani Unit of Dermatology, University of Parma, Parma, Italy
Micheal Tirant University of Rome G. Marconi, Rome, Italy; Psoriasis Eczema Clinic, Melbourne, Australia
Aleksandra Vojvodic Department of Dermatology and Venereology, Military Medical Academy of Belgrade, Belgrade, Serbia
Torello Lotti University of Rome G. Marconi, Rome, Italy

DOI:

https://doi.org/10.3889/oamjms.2019.092

Keywords:

Pityriasis versicolor, Malassezia, Yeast

Abstract

AIM: Compare itraconazole alone, fluconazole combined with ketoconazole and ketoconazole in the treatment of patients with pityriasis versicolor.

MATERIAL AND METHODS: A group of 240 pityriasis versicolor patients (confirmed with KOH and culture) were classified into 3 groups: Fluconazole 300 mg a week and 2% ketoconazole foam twice a week for 2 weeks (Category I), Itraconazole 200 mg daily for one week (category II); Ketoconazole 2% foam daily for 2 weeks (Category 3). Clinical (colour of macule, scale, pruritus) and mycological assessment were done after 4 weeks of therapy.

RESULTS: After 4 weeks of treatment, clinical cure was observed in 62.4% (Category I), 36.3% (Category II) and 37.5% (Category III).

CONCLUSION: It was reported in our study that the most effective regimen for PV patients is fluconazole 300 mg per week combined with ketoconazole 2% twice a week for 2 weeks.

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