The Study of the Wound Healing Activity of the Gel with a Comprehensive Therapeutic Effect

Liliana Lyubanovna Brkich; Andrey Anatolievich Nedorubov; Natalia Valeryevna Pyatigorskaya; Galina Eduardovna Brkich; Elena Sergeevna Odintsova

doi:10.3889/oamjms.2019.220

Authors

Liliana Lyubanovna Brkich Institute of Translational Medicine and Biotechnology, Sechenov First Moscow State Medical University, Trubetskaya Street, 8-2, Moscow, 119991, Russian Federation
Andrey Anatolievich Nedorubov Institute of Translational Medicine and Biotechnology, Sechenov First Moscow State Medical University, Trubetskaya Street, 8-2, Moscow, 119991, Russian Federation
Natalia Valeryevna Pyatigorskaya Institute of Translational Medicine and Biotechnology, Sechenov First Moscow State Medical University, Trubetskaya Street, 8-2, Moscow, 119991, Russian Federation
Galina Eduardovna Brkich Institute of Translational Medicine and Biotechnology, Sechenov First Moscow State Medical University, Trubetskaya Street, 8-2, Moscow, 119991, Russian Federation
Elena Sergeevna Odintsova Institute of Translational Medicine and Biotechnology, Sechenov First Moscow State Medical University, Trubetskaya Street, 8-2, Moscow, 119991, Russian Federation

DOI:

https://doi.org/10.3889/oamjms.2019.220

Keywords:

Chitosan-miramistin-hemopexin complex, Development of wound healing drugs, Models of linear and planar wounds, Wound treatment gel

Abstract

AIM: The study was aimed at researching the specific wound healing activity of the drug with a comprehensive therapeutic effect based on derivatives of glucosamine and acrylic polymers to treat the infected wounds of various origins on a model of a planar infected wound.

METHODS: The model of septic wounds in rats as per the method of P.I. Tolstykh was used during the study of the specific activity of the drug with a comprehensive therapeutic effect based on derivatives of glucosamine and acrylic polymers for the treatment of infected wounds. The infection was performed with the S. aureus and E. coli strains. The study lasted 18 days, and during this period no full scarring occurred. The wound diameter was chosen as the effectiveness criterion. The planimetric method was used to assess the course of the wound process in experimental animals.

RESULTS: The obtained data prove the specific action of the drug with a comprehensive therapeutic action based on derivatives of glucosamine and acrylic polymers to treat the infected wounds of various origins. The study has shown that bacterially infected wounds healed worse than noninfected ones. Both types of wounds â€” infected and uninfected ones â€” healed faster when applying the test drug or Levomekol ointment.

CONCLUSION: On the model of a planar infected wound, the developed drug with a comprehensive therapeutic action has shown better wound healing effect compared with the Levomekol reference drug.