Alveolar Cleft Reconstruction Using Different Grafting Techniques

Authors

  • Aida Mossaad Orodental Gernetics Department, National Research Center, Cairo, Egypt
  • Tarek El Badry Orodental Gernetics Department, National Research Center, Cairo, Egypt
  • Moustapha Abdelrahman Orodental Gernetics Department, National Research Center, Cairo, Egypt
  • Ahmad Abd Elazeem Orodental Gernetics Department, National Research Center, Cairo, Egypt
  • Wael Ghanem Plastic Pediatric Department at Ain Shams University, Cairo, Egypt
  • Susan Hassan Oral & Maxillofacial Surgery Department at Al Azhar University Girls, Nasr City, Cairo Governorate, Egypt
  • Nahed Adly Oral & Maxillofacial Surgery Department at Al Azhar University Girls, Nasr City, Cairo Governorate, Egypt
  • Wael Shawkat Oral & Maxillofacial Department at Nasr City Insurance Hospital, Nasr City, Cairo Governorate, Egypt

DOI:

https://doi.org/10.3889/oamjms.2019.236

Keywords:

Alveolar cleft, Hydroxy apatite, Stem cells, Iliac crest

Abstract

BACKGROUND: Cleft lip and palate CLP is a frequent congenital malformation that manifests in several varieties including unilateral or bilateral anomalies due to either genetic or acquired causes. Alveolar cleft graft ACG remains controversial as regard timing, grafting materials and surgical techniques. The primary goal of alveolar cleft grafting in ACG patients is to provide an intact bony ridge at the cleft site to allow maxillary continuity for teeth eruption, proper orthodontic treatment for dental arch alignment, oronasal fistula closure and providing alar support for nasal symmetry.

AIM: This study aims to compare different grafting techniques to treat the alveolar cleft defect.

METHODS: This study included 24 cases divided into three groups of patients: Group A was treated with autogenous iliac crest bone; Group B was treated with nano calcium hydroxyapatite with collagen membrane and Group C was treated with tissue engineering method using bone marrow stem cells extract and PRF membrane.

RESULTS: According to clinical and radiographic examination measuring bone density in the CT preoperatively compared to six months postoperatively. Group C with bone marrow stem cells extract showed superior results among all followed by group B, while group A with autogenous iliac crest showed resorption in some cases and gave the least values, in addition to its drawbacks as regard donor site affection with pain & scar formation.

CONCLUSION: Bone substitutes as Nano calcium hydroxyapatite and bone marrow stem cells extract showed to be reliable methods for bone grafting than autogenous iliac crest.

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References

Seifeldin S. Is alveolar cleft reconstruction still controversial? (Review of literature). Saudi Dental J. 2016; 28(1). https://doi.org/10.1016/j.sdentj.2015.01.006

Xiao WL, Zhang DZ, Chen XJ, Xue LF. Osteogenesis effect of guided bone regeneration combined with alveolar cleft grafting, assessement of cone beam computed tomography. Int J Oral Maxillofac Surg. 2016; 45(6):683. https://doi.org/10.1016/j.ijom.2016.01.013 PMid:26876144

Cho-Lee GY, García-Díez EM, Nunes RA, Martí-Pagès C, Sieira-Gil R, Rivera-Baró A. Review of secondary alveolar cleft repair. Annals of maxillofacial surgery. 2013; 3(1):46. https://doi.org/10.4103/2231-0746.110083 PMid:23662259 PMCid:PMC3645611

Boyne PJ. Secondary bone grafting of residual alveolar and palatal clefts. J Oral Surg. 1972; 30:87-92.

Bergland O, Semb G, Abyholm FE. Elimination of the residual alveolar cleft by secondary bone grafting and subsequent orthodontic treatment. The Cleft palate journal. 1986; 23(3):175-205.

Francis CS, Mobin SS, Lypka MA, Rommer E, Yen S, Urata MM, Hammoudeh JA. rhBMP-2 with a demineralized bone matrix scaffold versus autologous iliac crest bone graft for alveolar cleft reconstruction. Plastic and reconstructive surgery. 2013; 131(5):1107. https://doi.org/10.1097/PRS.0b013e3182865dfb PMid:23385986

Wahaj A, Hafeez K, Zafar MS. Role of bone graft materials for cleft lip and palate patients: A systematic review. The Saudi Journal for Dental Research. 2016; 7(1):57-63. https://doi.org/10.1016/j.sjdr.2015.02.001

Horswell BB, Henderson JM. Secondary osteoplasty of the alveolar cleft defect1. Journal of oral and maxillofacial surgery. 2003; 61(9):1082. https://doi.org/10.1016/S0278-2391(03)00322-7

Le BT, Woo I. Alveolar cleft repair in adults using guided bone regeneration with mineralized allograft for dental implant site development: a report of 2 cases. Journal of Oral and Maxillofacial Surgery. 2009; 67(8):1716. https://doi.org/10.1016/j.joms.2009.04.012 PMid:19615587

Sadove AM, Nelson CL, Eppley BL, Nguyen B. An evaluation of calvarial and iliac donor sites in alveolar cleft grafting. Cleft Palate Journal. 1990; 27(3):225-9. https://doi.org/10.1597/1545-1569_1990_027_0225_aeocai_2.3.co_2 PMid:2372971

Kraut RA. The use of allogeneic bone for alveolar cleft grafting. Oral surgery, oral medicine, oral pathology. 1987; 64(3):278-82. https://doi.org/10.1016/0030-4220(87)90003-X

Peamkaroonrath C, Godfrey K, Chatrchaiwiwatana S. New clinical method for alveolar bone graft evaluation in cleft patients: a pilot study. The Cleft Palate-Craniofacial Journal. 2011; 48(3):286-92. https://doi.org/10.1597/09-222 PMid:20572777

Fujihara K, Kotaki M, Ramakrishna S. Guided bone regeneration membrane made of polycaprolactone/calcium carbonate composite nano-fibers. Biomaterials. 2005; 26(19):4139-47. https://doi.org/10.1016/j.biomaterials.2004.09.014 PMid:15664641

Ratajczak MZ, Zuba-Surma EK, Wysoczynski M, Ratajczak J, Kucia M. Very small embryonic-like stem cells: characterization, developmental origin, and biological significance. Experimental hematology. 2008; 36(6):742-51. https://doi.org/10.1016/j.exphem.2008.03.010 PMid:18474305 PMCid:PMC2430762

Choukroun J, Diss A, Simonpieri A, Girard M-O, Dohan SL. Platelet rich fibrin a second generation of platelet concentrate. Oral Surg Med Oral Path Oral Radiol Endo. 2006; 101:56. https://doi.org/10.1016/j.tripleo.2005.07.011 PMid:16504852

Hernández P, Cortina L, Artaza H, Pol N, Lam RM, Dorticós E, Macías C, Hernández C, Del Valle L, Blanco A, Martínez A. Autologous bone-marrow mononuclear cell implantation in patients with severe lower limb ischaemia: a comparison of using blood cell separator and Ficoll density gradient centrifugation. Atherosclerosis. 2007; 194(2):e52-6. https://doi.org/10.1016/j.atherosclerosis.2006.08.025

Ehrenfest M. In search of consensus terminology in the field of platelet concentrates for surgical use: Platelet rich Plasma PRP, platelet rich fibrin PRF. 2015; 13:1131. https://doi.org/10.2174/138920112800624328

Zhou WN, Xu, Jiang HB, Du YF: Accurate evaluation of Cone beam CT to volumetrically asses alveolar cleft patients. 2015; 26:535. https://doi.org/10.1097/SCS.0000000000002034

Gillgras TJ, MacDonald JP, Mossey PA, Welbury RR. The impact of alveolar bone grafting on cleft lip and palate: a literature review. South European journal of orthodontics and dentofacial research. 2014; 1(1):19-22. https://doi.org/10.15538/sejodr-2014-21992

Jan Lilja: Alveolar Bone grafting. Indian Journal of Plastic Surgery. 2014; 42. https://doi.org/10.4103/0970-0358.57200

Masaahi T, Teru S, Yoshaiki S, Kazuo K: Assessement of bioabsorbable hydroxyapatite for secondary bone grafting in unilateral alveolar cleft. J Plastic Reconstructive & Aesthetic Surgery. 2015; 69:4. https://doi.org/10.1016/j.bjps.2015.10.040

Al-Ahmady HH, Elazeem AF, Ahmed NE, Shawkat WM, Elmasry M, Abdelrahman MA, Abderazik MA. Combining autologous bone marrow mononuclear cells seeded on collagen sponge with Nano Hydroxyapatite, and platelet-rich fibrin: Reporting a novel strategy for alveolar cleft bone regeneration. Journal of Cranio-Maxillofacial Surgery. 2018; 46(9):1593-600. https://doi.org/10.1016/j.jcms.2018.05.049 PMid:30196860

Bajestan MN, Rajan A, Edwards SP, Aronovich S, Cevidanes LH, Polymeri A, Travan S, Kaigler D. Stem cell therapy for reconstruction of alveolar cleft and trauma defects in adults: A randomized controlled, clinical trial. J Clin Implant Dent Relat Res. 2017; 19(5):793-801. https://doi.org/10.1111/cid.12506 PMid:28656723

Published

2019-04-29

How to Cite

1.
Mossaad A, El Badry T, Abdelrahman M, Abd Elazeem A, Ghanem W, Hassan S, Adly N, Shawkat W. Alveolar Cleft Reconstruction Using Different Grafting Techniques. Open Access Maced J Med Sci [Internet]. 2019 Apr. 29 [cited 2024 Apr. 20];7(8):1369-73. Available from: https://oamjms.eu/index.php/mjms/article/view/oamjms.2019.236

Issue

Section

D - Dental Sciences