Clinical Evaluation of 660 nm Diode Laser Therapy on the Pain, Size and Functional Disorders of Recurrent Aphthous Stomatitis

Hisham Abdelmonem Soliman; Diana Mostafa

doi:10.3889/oamjms.2019.268

Authors

Hisham Abdelmonem Soliman Faculty of Dentistry, Alexandria University, Alexandria, Egypt
Diana Mostafa Department of Preventive Dental Sciences, Al Farabi Colleges, Riyadh, Saudi Arabia

DOI:

https://doi.org/10.3889/oamjms.2019.268

Keywords:

Minor Aphthous Ulcers, Recurrent Aphthous Stomatitis Treatment, Diode Laser 660 nm

Abstract

BACKGROUND: Minor recurrent aphthous stomatitis (MiRAS) is one of the most common, recurrent, and painful mucosal pathological condition. It is characterised by round or shallow oval ulcers, less than 10 mm in diameter, surrounded by a thin erythematous halo. It involves non-keratinized mucosa such as the labial and buccal mucosa, the ventral surface or borders of the tongue and the floor of the mouth, but it is uncommon to occur on the keratinised mucosa. It heals spontaneously within 10-14 days without scarring. There is no curative remedy to prevent its recurrence; also, available modalities only reduce the symptoms and severity of the lesion.

AIM: Since these lesions may be extremely painful, we decided to estimate the pain-relieving and healing properties of low energy level laser therapy using diode laser 660 nm on MiRAS.

MATERIAL AND METHODS: Twenty healthy patients suffering from minor aphthous ulcers were randomly selected from the Out-Patient Clinic of Oral Medicine Department, Faculty of Dentistry, Alexandria University. They were equally divided into two groups, study group who received 660 nm diode laser irradiation while the control group received placebo (sodium bicarbonate rinse). The visual analogue scale, size reduction, effectiveness indices and functional disorders were compared between the groups.

RESULTS: Both groups presented a statistically significant difference from baseline to follow up periods. But, diode laser 660 nm treatment showed more remarkable improvements in reduction of healing time, pain and lesion size.

CONCLUSION: We concluded that diode laser 660 nm should be further considered as an effective alternative therapeutic regimen to patients who suffer from recurrent aphthous stomatitis.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Plum Analytics Artifact Widget Block

References

Shulman JD. An exploration of point, annual, and lifetime prevalence in characterising recurrent aphthous stomatitis in USA children and youths. J Oral Pathol Med. 2004; 33:558-66. https://doi.org/10.1111/j.1600-0714.2004.00241.x PMid:15357677

Altenburg A, Abdel Naser MB, Seeber H, Abdallah M, Zouboulis CC. Practical aspects of management of recurrent aphthous stomatitis. J Eur Acad Dermatol Venereol. 2007; 21:1019-26. https://doi.org/10.1111/j.1468-3083.2007.02393.x PMid:17714120

Miller MF, Ship II. A retrospective study of the prevalence and incidence of recurrent aphthous ulcers in a professional population, 1958-1971. Oral Surg Oral Med Oral Pathol. 1977; 43: 532-7. https://doi.org/10.1016/0030-4220(77)90105-0

Jurge S, Kuffer R, Scully C, Porter SR. Recurrent aphthous stomatitis. Oral Dis. 2006; 12:1-21. https://doi.org/10.1111/j.1601-0825.2005.01143.x PMid:16390463

Crivelli MR, Aguas S, Adler I, Quarracino C, Bazergue P. Influence of socio-economic status on oral mucosa lesion prevalence in schoolchildren. Community Dent Oral Epidemiol. 1988; 16:58-60. https://doi.org/10.1111/j.1600-0528.1988.tb00556.x PMid:3422621

Scully C, Felix DH. Oral medicine-update for the dental practitioner. Aphthous and other common ulcers. British Dent Journal. 2005; 199(5):259-264. https://doi.org/10.1038/sj.bdj.4812649 PMid:16155535

Ship JA. Recurrent aphthous stomatitis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1996; 81:141-7. https://doi.org/10.1016/S1079-2104(96)80403-3

Scully C, Gorsky M, Lozada-Nur F. The diagnosis and management of recurrent aphthous stomatitis: a consensus approach. J Am Dent Assoc. 2003; 134:200-7. https://doi.org/10.14219/jada.archive.2003.0134 PMid:12636124

Mester AF, Mester A. Wound-healing. Laser Therapy. 1989; 1:7-15. https://doi.org/10.5978/islsm.89-RE-01

Walker J. Relief from chronic pain by low power laser irradiation. Neurosci Lett. 1983; 43:339-44. https://doi.org/10.1016/0304-3940(83)90211-2

Ohta A, Abergel RP, Uitto J. Laser modulation of human immune system: inhibition of lymphocyte proliferation by a gallium-arsenide laser at low energy. Lasers Surg Med. 1987; 7:199-201. https://doi.org/10.1002/lsm.1900070211 PMid:2956471

Ricci L, WeidemÃ¼ller M, Esslinger T, Hemmerich A, Zimmermann C, Vuletic V, et al. A compact grating- stabilized diode laser system for atomic physics. Opt Commun. 1995; 117:541-9. https://doi.org/10.1016/0030-4018(95)00146-Y

Moritz A, Gutknecht N, Doertbudak O, Goharkhay K, Schoop U, Schauer P, et al. Bacterial reduction in periodontal pockets through irradiation with diode laser, A pilot study. J Clin Laser Med Surg. 1997; 15:33-7. https://doi.org/10.1089/clm.1997.15.33 PMid:9467340

Scully C and Porter SR. Oral mucosal disease: recurrent aphthous stomatitis. Bri Dent J. 2008; 46(3):198-206. https://doi.org/10.1016/j.bjoms.2007.07.201 PMid:17850936

Greenberg M, Glick M. Orofacial pain: Burket's Oral Medicine Diagnosis and Treatment, tenth edition. Hamilton: BC Decker Inc. 2003:310.

Liu J, Zeng X, Chen Q, Cai Y. An evaluation on the efficacy and safety of Amlexanox oral adhesive tablets in the treatment of recurrent minor aphthous ulceration in a Chinese cohort: A randomized, double blind controlled, unparallel clinical trial. Oral Surg Oral Med Oral Path Oral Radiol Endod 2006; 102:475-81. https://doi.org/10.1016/j.tripleo.2005.12.014 PMid:16997114

Tuzun B, Wolf R, Tuzun Y, Serdaroglu S. Recurrent aphthous stomatitis and smoking. Int J Dermatol. 2000; 39:358-60. https://doi.org/10.1046/j.1365-4362.2000.00963.x PMid:10849126

Zain RB. Oral recurrent aphthous ulcers/stomatitis: prevalence in Malaysia and an epidemiological update. J Oral Sci. 2000; 42:15-9. https://doi.org/10.2334/josnusd.42.15 PMid:10808270

Rivera-Hidalgo F, Shulman JD, Beach MM. The association of tobacco and other factors with recurrent aphthous stomatitis in an US adult population. Oral Dis. 2004; 10:335-45. https://doi.org/10.1111/j.1601-0825.2004.01049.x PMid:15533208

Sircus M. Sodium bicarbonate - rich man's poor man's cancer treatment. 2nd ed. Ch 1. IMVA publications, 2009:10-11.

Laakso EL, Richardson CR, Cramond T. Factors affecting low level laser therapy. Aust J Physio. 1993; 39:95-99. https://doi.org/10.1016/S0004-9514(14)60473-6

Colvard M, Kuo P. Managing aphthous ulcers: laser treatment applied. J Am Dent Assoc. 1991; 122:51-3. https://doi.org/10.1016/S0002-8177(91)26017-1

Zand N, Ataie-Fashtami L, Djavid GE, Fateh M, Alinaghizadeh M-R, Fatemi S-M, et al. Relieving pain in minor aphthous stomatitis by a single session of non- thermal carbon dioxide laser irradiation. Lasers Med Sci. 2009; 24:515-20. https://doi.org/10.1007/s10103-008-0555-1 PMid:18408986

Zand N, Fateh M, Ataie-Fashtami L, Djavid GE, Fatemi S-M, Shirkavand A. Promoting wound healing in minor recurrent aphthous stomatitis by non-thermal, non-ablative CO2 laser therapy: a pilot study. Photomed Laser Surg. 2012; 30:719. https://doi.org/10.1089/pho.2012.3301 PMid:23113511

Prasad S, Pai A. Assessment of immediate pain relief with laser treatment in recurrent aphthous stomatitis. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013; 116:189-93. https://doi.org/10.1016/j.oooo.2013.02.011 PMid:23622766

Conlan MJ, Rapley JW, Cobb CM. Biostimulation of wound healing by low-energy laser irradiation: a review. J Clin Periodontol. 1996; 23:492-6. https://doi.org/10.1111/j.1600-051X.1996.tb00580.x PMid:8783057

Rodriguez M, Rubio JA, Sanchez R. Effectiveness of two oral pastes for the treatment of recurrent aphthous stomatitis. Oral Dis. 2007; 13:490-4. https://doi.org/10.1111/j.1601-0825.2006.01327.x PMid:17714352

De Souza TO, Martins MA, Bussadori SK, Fernandes KP, Tanji EY, Mesquita-Ferrari RA, et al. Clinical evaluation of low-level laser treatment for recurring aphthous stomatitis. Photomed Laser Surg. 2010; 28:S85-8. https://doi.org/10.1089/pho.2009.2661 PMid:20950190

Khademi H, Shirani AM, Nikegbal F. Effect of low power laser in the treatment of recurrent oral aphthous. Shiraz Univ Dent J. 2009; 10:160-2.

Aggarwal H, Singh MP, Nahar P, Mathur H, Gv S. Efficacy of low-level laser therapy in treatment of recurrent aphthous ulcers - a sham controlled, split mouth follow up study. J Clin Diagn Res. 2014; 8(2):218-221. https://doi.org/10.7860/JCDR/2014/7639.4064 PMid:24701539 PMCid:PMC3972568

Hazeem MI, Rajab M sh, Badeia RA. Treatment of Recurrent Aphthous Stomatitis with 940nm Diode Laser. Tikrit J Dent Sci. 2013; 1:77-82.

Lalabonova H, Daskalov H. Clinical assessment of the therapeutic effect of low-level laser therapy on chronic recurrent aphthous stomatitis. Biotechnol Equip. 2014; 28:929-33. https://doi.org/10.1080/13102818.2014.966526 PMid:26019580 PMCid:PMC4433909

Tezel A, Kara C, Balkaya V, Orbak R. An evaluation of different treatments for recurrent aphthous stomatitis and patient perceptions: Nd:YAG laser versus medication. Photomed Laser Surg. 2009; 27: 101-6. https://doi.org/10.1089/pho.2008.2274 PMid:18687056

Arabaci T, Kara C, CiÃ§ek Y. Relationship between periodontal parameters and BehÃ§et's disease and evaluation of different treatments for oral recurrent aphthous stomatitis. J Periodontal Res. 2009; 44:718-25. https://doi.org/10.1111/j.1600-0765.2008.01183.x PMid:19076988