The Difference of Serum Gastrin-17 Level Based on Gastritis Severity and Helicobacter Pylori Infection
DOI:
https://doi.org/10.3889/oamjms.2019.325Keywords:
Helicobacter pylori, Gastritis, Gastrin-17Abstract
BACKGROUND: Gastritis was defined as the histological presence of gastric mucosal inflammation. One of the most common aetiology was H. pylori. Gastrin-17 was a hormone that was secreted by G cells. H. pylori infection induced increased in gastrin-17 in gastritis. Therefore, this study was to investigate the relationship of gastrin-17 with gastritis severity and H. pylori infection.
AIM: To determine the difference in serum Gastrin-17 level based on gastritis severity and H. pylori infection.
METHODS: A cross-sectional study enrolling 45 patients with gastritis was conducted in Haji Adam Malik General Hospital between April and July 2018. Endoscopy and biopsy examinations were performed to confirm the diagnosis of gastritis. Gastritis severity was assessed using the Updated Sydney System. The presence of H. pylori infection was detected by a Campylobacter-like organism (CLO) examination. Gastrin-17 level and demographic data were also gathered. The analysis was done using Mann Whitney and Kruskal-Wallis test. P-value of < 0.05 was considered statistically significant.
RESULTS: Serum Gastrin-17 level was significantly different based on gastritis severity (P = 0.001 according to neutrophils infiltration and P = 0.023 according to degree of atrophy), H. pylori infection (P = 0.038), and combined gastritis severity and H. pylori infection (P < 0.001). Serum Gastrin-17 level was higher in subjects with severe neutrophils infiltration, without atrophy, and with H. pylori infection.
CONCLUSION: There was a significant difference in serum Gastrin-17 level based on gastritis severity and H. pylori infection.
Downloads
Metrics
Plum Analytics Artifact Widget Block
References
Nurdin W, Krisnuhoni E, Kusmardi. Comparison of Helicobacter pylori: detection using immunochemistry and Giemsa and its association with morphological changes in active chronic gastritis. Indones J Gastroenterol Hepatol Digest Endosc. 2016; 17(1):21-7. https://doi.org/10.24871/171201621-27
Croft DN. Gastritis. Br Med J. 1967; 4(5572):164-6. https://doi.org/10.1136/bmj.4.5572.164 PMid:4861383 PMCid:PMC1750051
Kayacetin S, Guresci S. Stomach: What is gastritis? What is gastropathy? How is it classified? Turk J Gastroenterol. 2014; 25:233-47. https://doi.org/10.5152/tjg.2014.7906 PMid:25141310
Liu Y, Vosmaer GDC, Tytgat GNJ, Xiao S, et al. Gastrin (G) cells and somatostatin (D) cells in patients with dyspeptic symptoms: Helicobacter pylori associated and non-associated gastritis. J Clin Pathol. 2005; 58(9):927-31. https://doi.org/10.1136/jcp.2003.010710 PMid:16126872 PMCid:PMC1770830
Park SM, Lee HR, Kim JG, et al. Effect of Helicobacter pylori infection on antral gastrin and somatostatin cells and on serum gastrin concentration. Korean J Intern Med. 1999; 14(1):15-20. https://doi.org/10.3904/kjim.1999.14.1.15 PMid:10063309 PMCid:PMC4531904
Sheykholeslami AH, Rakhshani N, Amirzargar A, et al. Serum Pepsinogen I, Pepsinogen II, and Gastrin-17 in relatives of gastric cancer patients: Comparartive Study with Type and Severity of Gastritis. Clin Gastroenterol Hepatol. 2008; 6:174-9. https://doi.org/10.1016/j.cgh.2007.11.016 PMid:18237867
Vaananen H, Vauhkonen M, Helske T, et al. Non endoscopic diagnosis of atrophic gastritis with a blood test. Correlation between gastric histology and serum level of gastrin-17 and pepsinogen I: a multicentre study. Eur J Gastroenterol Hepatol. 2003; 15(8):885-91. https://doi.org/10.1097/00042737-200308000-00009 PMid:12867799
Sipponen P, Maaroos HI. Chronic gastritis. Scand J Gastroenterol. 2015; 50(6):657-67. https://doi.org/10.3109/00365521.2015.1019918 PMid:25901896 PMCid:PMC4673514
Calam J, Gibbons A, Healey ZV, et al. How does H. pylori cause mucosal damage? Its effect on acid and gastrin physiology. Gastroenterology. 1997; 119(6):S43-9. https://doi.org/10.1016/S0016-5085(97)80010-8
Dacha S, Razvi M, Massaad J, et al. Hypergastrinemia. Gastroenterol Report. 2015; 3(3):201-8. https://doi.org/10.1093/gastro/gov004 PMid:25698559 PMCid:PMC4527266
Ebule IA, Djune Fokou AK, Sitedjeyi, et al. Prevalence of H. pylori infection and atrophic gastritis among dyspeptic subjects in Cameroon using a panel of serum biomarkers (PGI,PGII,G17,HpIg). Sch J App Med Sci. 2017; 5(4A):1230-9.
Huang XQ. Helicobacter pylori infection and gastrointestinal hormones: a review. World J Gastroenterol. 2000; 6(6):783-8. https://doi.org/10.3748/wjg.v6.i6.783 PMid:11819696 PMCid:PMC4728263
Jensen PJ, Feldman M. Acute and chronic gastritis due to Helicobacter pylori. In: Lamont JT, Grover S (Eds). Up-to-date. 2019. Available from : https://www.uptodate.com/contents/acute-and-chronic-gastritis-due-to-helicobacter-pylori?source=history_widget
Prosapio JG, Jialal I. Physiology, Gastrin. Treasure island: StatPearls Publishing, 2018. Available from: https://www.ncbi.nlm.nih.gov/books/NBK534822/
Kusters JG, Van Vliet AHM, Kuipers EJ. Pathogenesis of Helicobacter pylori Infection. Clin Microbiol Rev. 2006; 19(3):449-90. https://doi.org/10.1128/CMR.00054-05 PMid:16847081 PMCid:PMC1539101
Siregar GA, Halim S, Sitepu RR. Serum TNFα, IL8, VEGF levels in Helicobacter pylori infection and their association with degree of gastritis. Acta Med Indones-Indones J of Intern Med. 2015; 47(2):120-6.
Dai YC, Tang ZP, Zhang YL. How to assess the severity of atrophic gastritis. World J Gastroenterol. 2011; 17(13):1690-3. https://doi.org/10.3748/wjg.v17.i13.1690 PMid:21483628 PMCid:PMC3072632
Kikuchi R, Abe Y, Iijima K, et al. Low serum levels of Pepsinogen and Gastrin-17 are predictive of extensive gastric atrophy with high-risk of early gastric cancer. Tohoku J Exp Med. 2011; 223:35-44. https://doi.org/10.1620/tjem.223.35 PMid:21222340
Odum L, Petersen HD, Andersen IB, et al. Gastrin and somatostatin in Helicobacter pylori infected antral mucosa. Gut. 1994; 35:615-8. https://doi.org/10.1136/gut.35.5.615 PMid:7911115 PMCid:PMC1374743
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2019 Dumawan Harris Parhusip, Gontar Alamsyah Siregar, Leonardo Basa Dairi
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
http://creativecommons.org/licenses/by-nc/4.0
