Determination of the Product of DNA Oxidation in the Blood of Women Living in the Sub-Aral Area

Swetlana Dzhangildinova; Swetlana Ivassenko; Assel Kelmyalene; Bayan Yessilbayeva; Bayan Dyussenbekova; Margulan Kinayatov

doi:10.3889/oamjms.2019.333

Authors

Swetlana Dzhangildinova Karaganda State Medical University, Karagandy, Kazakhstan
Swetlana Ivassenko Karaganda State Medical University, Karagandy, Kazakhstan
Assel Kelmyalene Karaganda State Medical University, Karagandy, Kazakhstan
Bayan Yessilbayeva Karaganda State Medical University, Karagandy, Kazakhstan
Bayan Dyussenbekova Karaganda State Medical University, Karagandy, Kazakhstan
Margulan Kinayatov Karaganda State Medical University, Karagandy, Kazakhstan

DOI:

https://doi.org/10.3889/oamjms.2019.333

Keywords:

Aral Sea region, Oxidative stress, 8-OH-deoxyguanosine, Reproductive health

Abstract

To assess the impact of climatic and anthropogenic factors of the Aral Sea region on reproductive health, we examined 300 women living in the Kyzylorda region of Kazakhstan, which borders the Aral Sea region. The survey was based on comprehensive clinical-functional and laboratory studies accounting on regional environmental and ecological factors. The survey subject was the area of 2 settlements in Kyzylorda region. In both areas, it was revealed that the examined women of the age group 30-39 years old had increased values of oxidative stress indices comparison with Atasu village of Karaganda region

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Plum Analytics Artifact Widget Block

References

Gaybullaev B, Chen S-C, Gaybullaev D. Changes in water volume of the Aral Sea after 1960. Appl Water Sci. 2012; 2:285 - 91. https://doi.org/10.1007/s13201-012-0048-z

Liston E. Satellite images show Aral Sea basin 'completely dried'. The Guardian. London: Guardian News and Media Limited. Retrieved. 2014.

Weinthal E. State Making and Environmental Cooperation. Cambridge, MA: The MIT Press; 2002. https://doi.org/10.7551/mitpress/6440.001.0001 PMid:12045535

WÃ¦hler TA, Dietrichs ES. The vanishing Aral Sea: health consequences of an environmental disaster. Tidsskrift for den Norske laegeforening: tidsskrift for praktisk medicin, ny raekke. 2017; 137(18). https://doi.org/10.4045/tidsskr.17.0597 PMid:28972331

Dust Storm, Aral Sea Archived October 5, 2013, at the Wayback Machine, NASA Earth Observatory image, June 30, 2001.

Whish-Wilson P. The Aral Sea environmental health crisis. Journal of Rural and Remote Environmental Health. 2002; 1(2):29-34.

Kultanov BZ, Dosmagambetova RS, Ivasenko SA et al. The Study of Cellular and Molecular Physiological Characteristics of Sperm in Men Living in the Aral Sea Region. Open Access Maced J Med Sci. 2016; 4:5-8. https://doi.org/10.3889/oamjms.2016.007 PMid:27275320 PMCid:PMC4884251

Turdybekova YG, Dosmagambetova RS, Zhanabayeva SU et al. The Health Status of the Reproductive System in Women Living In the Aral Sea Region. Open Access Maced J Med Sci. 2015; 3:474-7. https://doi.org/10.3889/oamjms.2015.078 PMid:27275273 PMCid:PMC4877842

Efimenko OA, Yuzko AM, Yarotskaya NV. Oxidative stress and reproductive health. Reproductive endocrinology. 2018; 3(41):66-72. https://doi.org/10.18370/2309-4117.2018.41.66-72

Kasai H, Hayami H, Yamaizumi Z, Saito H, Nishimura S. Detection and identification of mutagens and carcinogens as their adducts with guanosine derivatives. Nucleic acids research. 1984; 12(4):2127-36. https://doi.org/10.1093/nar/12.4.2127 PMid:6701096 PMCid:PMC318645

Nevredimova TS, Marmius NV, Esipov DS, Esipova OV, Shvets VI. 8-Oxo-2'-deoxyguanosine is a biomarker of oxidative stress. Lomonosov Moscow State University of Fine Chemical Technologies Herald. 2014; 9(5):3-10.

European Standards Committee on Oxidative DNA Damage (ESCODD. Measurement of DNA oxidation in human cells by chromatographic and enzymic methods. Free Radical Biology and Medicine. 2003; 34(8):1089-99. https://doi.org/10.1016/S0891-5849(03)00041-8

ESCODD (European Standards Committee on Oxidative DNA Damage). Comparative analysis of baseline 8-oxo-7, 8-dihydroguanine in mammalian cell DNA, by different methods in different laboratories: an approach to consensus. Carcinogenesis. 2002; 23(12):2129-33. https://doi.org/10.1093/carcin/23.12.2129 PMid:12507938

Zhanataev AK, Seredenin SB, Durnev AD. Prospects for the determination of 8-hydroxy-2-deoxyguanosine as a biomarker of oxidative stress in experiment and clinic. Bulletin of the Russian Academy of Medical Sciences. 2002; 2:45-49.