Differences of Fasting Blood Glucose Level in People with Schizophrenia between Before and After Getting Aripiprazole Treatment

Dahlia Rosally Turangan; Bahagia Loebis; Surya M. Husada; Nazli Mahdinasari Nasution

doi:10.3889/oamjms.2019.403

Authors

Dahlia Rosally Turangan Residency Program in Psychiatry, Faculty of Medicine Universitas Sumatera Utara, Medan, Indonesia
Bahagia Loebis Department of Psychiatry, Faculty of Medicine Universitas Sumatera Utara, Medan, Indonesia
Surya M. Husada Department of Psychiatry, Faculty of Medicine Universitas Sumatera Utara, Medan, Indonesia
Nazli Mahdinasari Nasution Department of Psychiatry, Faculty of Medicine Universitas Sumatera Utara, Medan, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2019.403

Keywords:

Fasting Blood Glucose, Aripiprazole, Schizophrenia

Abstract

BACKGROUND: Schizophrenia is a serious disorder of the brain and mind. People with schizophrenia are at high risk of developing type diabetes, due to overall poor physical health, poor health care, unhealthy lifestyles, and side effects of antipsychotic drugs. However, atypical antipsychotics have their deficiencies, because they can be associated with worsening cardiovascular risk factors such as weight gain, hyperglycemia and hyperlipidemia.

AIM: Difference in fasting blood glucose levels in people with schizophrenia between before and after receiving aripiprazole treatment.

METHODS: This research was conducted in November 2017-September 2018. This research was first conducted in Indonesia, especially North Sumatra. This research is a numerical comparative analytical study paired with an experimental design approach. The number of samples is 44 people. Blood samples are taken in schizophrenia patients before getting the drug, before meals and before activities, assessed fasting blood glucose levels before being treated with aripiprazole and after drug administration for 6 weeks. Data analysis used was a paired test for differences in fasting blood glucose levels in people with schizophrenia between before and after receiving aripiprazole treatment.

RESULTS: Based on the demographic characteristics found the research subjects based on the most age group were 31-40 years age group of 30 subjects (68.2%), based on the highest level of education was high school by 26 subjects (59.1%), based on the most marital status was by status not married for 24 subjects (54.5%). It was found that the average blood glucose level before being given aripiprazole in schizophrenic patients was 89.23 Â± 7.13. It was found that the average blood glucose level after being given aripiprazole in schizophrenic patients was 86.5 Â± 10.1. It was found that there were no differences in blood glucose levels before and after being given aripiprazole in schizophrenic patients

CONCLUSION: There was no difference in blood glucose levels before and after being given aripiprazole in schizophrenic patients with p-value (0.078).