Curcumin’s Effect оn COX-2 аnd IL-10 Serum in Preeclampsia’s Patient Undergo Sectio Caesarea with Spinal Anesthesia
DOI:
https://doi.org/10.3889/oamjms.2019.426Keywords:
Curcumin, Cyclooxcygenase 2 (COX-2), Interleukin-10 (IL-10), Preeclampsia, Spinal AnesthesiaAbstract
BACKGROUND: Curcumin is a major component in curcuminoid which acts as an anti-inflammatory agent. Curcumin affects several biological markers that are thought to play a role in the pathogenesis of preeclampsia such as IL-10 and COX-2, resulting in an improvement in pregnant women with preeclampsia.
AIM: To see the effect of perioperative curcumin administration on IL-10 and COX-2 in preeclamptic patients undergoing caesarean section under spinal anaesthesia.
METHODS: This study was a double-blind, randomised clinical trial conducted at Pirngadi Hospital, USU Hospital and Sundari General Hospital Medan as a hospital network of Faculty of Medicine, North Sumatra University. Group 1 received a drug containing curcumin (as a treatment), and another group received a placebo (as a control).
RESULTS: There were no significant differences in the median values of COX-2 and IL-10 before and after treatment and also the p-values were greater than 0.05 in both groups (control and treatment).
CONCLUSION: There is no significant difference between the use of curcumin on serum COX-2 and IL-10 levels.
Downloads
Metrics
Plum Analytics Artifact Widget Block
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2019 Wulan Fadinie, Aznan Lelo, Dadik Wahyu Wijaya, Sarma Nursani Lumbanraja (Author)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
http://creativecommons.org/licenses/by-nc/4.0