Polymorphisms of CYP2E1 rs2031920 is not Associated with Risk of Nasopharyngeal Carcinoma in Minangkabau Ethnic Group

Sukri Rahman; Eti Yerizel; Daan Khambri; Djong Hon Tjong

doi:10.3889/oamjms.2019.429

Authors

Sukri Rahman Faculty of Medicine, Andalas University, Padang, Indonesia
Eti Yerizel Faculty of Medicine, Andalas University, Padang, Indonesia
Daan Khambri Faculty of Medicine, Andalas University, Padang, Indonesia
Djong Hon Tjong Faculty of Mathematics and Natural Sciences, Andalas University, Padang, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2019.429

Keywords:

CYP2E1 polymorphisms, Nasopharyngeal Carcinoma, Minangkabau

Abstract

BACKGROUND: Various environmental factors have been suspected to be associated with the risk of developing Nasopharyngeal Carcinoma (NPC). Volatile nitrosamines found in salted fish are thought to be carcinogenic substances for NPC. Nitrosamines are activated by the CYP2E1 enzyme. Several studies investigated the relationship between polymorphism in the CYP2E1 gene and susceptibility to NPC, but the results obtained were inconsistent.

AIM: This study was conducted to analyse the association of the CYP2E1 rs2031920 polymorphisms with the incidence of NPC in the Minangkabau ethnic group.

METHODS: The subjects of this study were newly diagnosed NPC Minangkabau ethnic patients, while the controls were healthy people. A total of 23 cases of NPC and 23 aged (Â± 3 years) and sex-matched controls participated in the study. The method used to identify these polymorphisms is PCR sequencing.

RESULTS: On recent study, we found CYP2E1 rs2031920 gene polymorphism in both the NPC and control groups, in the NPC group there were 8.7% heterozygote mutants while in the control group there were 26.1% heterozygote mutants, and there were no homozygote mutants in the two groups, and statistically none a significant relationship between CYP2E1 gene polymorphism and the incidence of NPC, with p > 0.05.

CONCLUSION: Our study reveals that there is no association of CYP2E1 gene polymorphism (rs2031920) with the incidence of nasopharyngeal carcinoma in the Minangkabau ethnic group.

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