The Inhibitory Activity of Picria fel-terrae Lour Herbs Extract on Nitric Oxide Production toward RAW 264.7 Cells Induced by Lipopolysaccharide
Keywords:Picria fel-terrae Lour Herbs Extract, Nitric Oxide production, Immunosuppresive effects
AIM: The objective of this study was to evaluate the inhibitory activity of Picria fel-terrae Lour on Nitric Oxide production toward RAW 264.7 cells.
METHODS: The extraction was obtained by maceration method using n-hexane, ethyl acetate and ethanol solvents and then nitric oxide (NO) production was obtained using Griess reagent.
RESULTS: Extract of Picria fel-terrae Lour herbs can reduce the NO production toward RAW 264.7 cells with induced by lipopolysaccharide has obtained nitric concentrations 12.5 and 25 Î¼g/mL from n-hexane extract (72.50 Â± 4.51 and 10.42 Â± 1.82), ethyl acetate extract: (88.33 Â± 6.51 and 30.83 Â± 6.86), ethanol extract: (75.00 Â± 1.91 and 22.08 Â± 2.53).
CONCLUSION: n-hexane extract of Picria fel-terrae Lour Herbs has a high potential to reduce the NO production in LPS-stimulated RAW 264.7 cells compared to ethyl acetate and ethanol extracts of Picria fel-terrae Lour Herbs.
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Copyright (c) 2019 Novycha Auliafendri, Rosidah Rosidah, Yuandani Yuandani, Sri Suryani, Denny Satria (Author)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.