In Vivo Activities and In Silico Study of Jackfruit Seeds (Artocarpus heterophyllus Lam.) on the Reduction of Blood Sugar Levels of Gestational Diabetes Rate Induced by Streptozotocin

Authors

  • Dwitiyanti Dwitiyanti Faculty Pharmacy and Science, Muhammadiyah Prof. Dr. Hamka University (UHAMKA), Islamic Center, Jl. Delima II/IV Perumnas Klender, East Jakarta, Indonesia
  • Rizky Arcinthya Rachmania Faculty Pharmacy and Science, Muhammadiyah Prof. Dr. Hamka University (UHAMKA), Islamic Center, Jl. Delima II/IV Perumnas Klender, East Jakarta, Indonesia
  • Kriana Efendi Faculty Pharmacy and Science, Muhammadiyah Prof. Dr. Hamka University (UHAMKA), Islamic Center, Jl. Delima II/IV Perumnas Klender, East Jakarta, Indonesia
  • Riri Septiani Faculty Pharmacy and Science, Muhammadiyah Prof. Dr. Hamka University (UHAMKA), Islamic Center, Jl. Delima II/IV Perumnas Klender, East Jakarta, Indonesia
  • Pahlevi Jihadudin Faculty Pharmacy and Science, Muhammadiyah Prof. Dr. Hamka University (UHAMKA), Islamic Center, Jl. Delima II/IV Perumnas Klender, East Jakarta, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2019.512

Keywords:

Artocarpus heterophyllus, streptozotocin, gestational diabetes, in silico, in vivo

Abstract

BACKGROUND: Jackfruit Seeds (Artocarpus heterophyllus L.) are plants that are thought to be able to reduce blood sugar levels.

AIM: The purpose of this study was to prove the activity of jackfruit seeds in reducing blood glucose levels in gestational diabetic rats induced by streptozotocin and in silico study virtual screening through molecular docking to find out the compounds in jackfruit seeds that have interaction with sulfonylurea receptors.

METHODS: The animals used in this study were Sprague Dawley strain pregnant female rats which were divided into six groups, namely the normal control group, negative control, positive control, various dose groups (100 mg/kg BW, 200 mg/kg BW, 400 mg/kg BW). After the rat was pregnant, the rats were induced first with streptozotocin so that the rats had hyperglycemia. Blood glucose levels were measured on the 14th day after treatment. The data obtained were statistically tested by one-way ANOVA test followed by the HSD Tukey test. Virtual screening was done using PLANTS 1.2 software.

RESULTS: The results showed that all groups of ethanol extract 70% of jackfruit seeds could reduce blood glucose levels. The biggest decrease in blood glucose levels occurred at dose 3 with a dose of 400 mg/kg BW which was 61.73%, comparable to positive control glibenclamide. The results of virtual screening with molecular docking showed that betacarotene epoxide compounds have better affinity than glibenclamide as a comparative compound.

CONCLUSION: It can be concluded that jackfruit seeds beta-carotene epoxide has the potential to reduce blood sugar levels by inducing insulin secretion.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Plum Analytics Artifact Widget Block

Published

2019-11-14

How to Cite

1.
Dwitiyanti D, Rachmania RA, Efendi K, Septiani R, Jihadudin P. In Vivo Activities and In Silico Study of Jackfruit Seeds (Artocarpus heterophyllus Lam.) on the Reduction of Blood Sugar Levels of Gestational Diabetes Rate Induced by Streptozotocin. Open Access Maced J Med Sci [Internet]. 2019 Nov. 14 [cited 2024 Mar. 28];7(22):3819-26. Available from: https://oamjms.eu/index.php/mjms/article/view/oamjms.2019.512

Issue

Section

Herbal Medicine in Pharmaceutical and Clinical Sciences

Similar Articles

You may also start an advanced similarity search for this article.