Antiarthritic Activity of Achyranthes Aspera on Formaldehyde - Induced Arthritis in Rats

Authors

  • Velmurugan Chinnasamy Department of Chemistry, Toxicology Unit, College of Natural Sciences, Arba Minch University, Ethiopia
  • Vetriselvan Subramaniyan Department of Pharmacology, Faculty of Medicine, MAHSA University, Malaysia
  • Sarath Chandiran School of Pharmacy, Sri Balaji Vidyapeeth Deemed University, India
  • Saminathan Kayarohanam Faculty of Bio-economy and Health Sciences, Geomatika University College Kuala Lumpur, Malaysia
  • Dhanapal Сhidambaram Kanniyan Department of Pharmacy, Annamalai University, India
  • Venkata Sathya Saiappala Raju Velaga Faculty of Pharmacy, MAHSA University, Malaysia
  • Shafiulla Muhammad Department of Pharmacology, Sri Krishna Chaithanya College of pharmacy, Madanapalle, Andhra Pradesh, India

DOI:

https://doi.org/10.3889/oamjms.2019.559

Keywords:

Achyranthesaspera, Formaldehyde, Arthritis, Anti-arthritis

Abstract

AIM: To determine the ameliorative potential of aqueous extract of Achyranthesaspera(AEAA) against arthritis using swiss albino mice and Wistar rats, and its possible mechanism of action.

METHODS: Swiss albino mice (25-30 g) and Wistar rats (150-180 g) under standard controlled conditions (24 ± 2°C, 50-70 humidity and 12 h light/dark cycle). The groups were divided into 6 groups (n = 6/group) and assigned as control, negative control, standard and, formaldehyde supplemented with two different test dose groups of A. aspera for 4 weeks. Arthritis induced by subplantar administration of 0.1 ml formaldehyde (2% v/v) into the left hind paw in all groups except normal control. Arthritis was assessed using serum Hb, ESR, paw volume, joint diameter, radiological and histopathological investigation.

RESULTS: Oral administration of AEAA shown a significant (p < 0.01) dose-dependent protection against formaldehyde induced arthritis. At 21st day, A.asperashown an inhibition of paw volume in the different doses of 250 mg/kg and 500 mg/kg were found to be 30% and, 38.33% respectively. At 14th day the joint swelling was found to be 27.2% and 36.36 respectively. Diclofenac (10 mg/kg) had an effect of 36.61% inhibition of arthritis and joint swelling at 21st and 14th day.

CONCLUSION: Thus, the present study revealed that the aqueous extract of A. aspera offered significant protection against arthritis and joint inflammation.

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Published

2019-08-30

How to Cite

1.
Chinnasamy V, Subramaniyan V, Chandiran S, Kayarohanam S, Kanniyan D Сhidambaram, Velaga VSSR, Muhammad S. Antiarthritic Activity of Achyranthes Aspera on Formaldehyde - Induced Arthritis in Rats. Open Access Maced J Med Sci [Internet]. 2019 Aug. 30 [cited 2022 Jul. 1];7(17):2709-14. Available from: https://oamjms.eu/index.php/mjms/article/view/oamjms.2019.559

Issue

Section

A - Basic Science

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