The Difference of Angiopoietin-2 Levels between Dengue Hemorrhagic Fever Patients with Shock and without Shock

Rinang Mariko; Eryati Darwin; Yanwirasti Yanwirasti; Sri Rezeki Hadinegoro

doi:10.3889/oamjms.2019.569

Authors

Rinang Mariko Postgraduate Biomedical Science, Faculty of Medicine, Andalas University, Padang, Indonesia; Department of Pediatrics, Faculty of Medicine, Andalas University, General Hospital of Dr M. Djamil, Padang, Indonesia
Eryati Darwin Department of Histology, Faculty of Medicine, Andalas University, Padang, Indonesia
Yanwirasti Yanwirasti Department of Anatomy, Faculty of Medicine, Andalas University, Padang, Indonesia
Sri Rezeki Hadinegoro Department of Pediatrics, Faculty of Medicine, Indonesia University, Jakarta, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2019.569

Keywords:

Angiopoietin-2, Dengue Hemorrhagic Fever (DHF), Shock

Abstract

BACKGROUND: Dengue infection is one of the problems in the national health sector in Indonesia because the incidence and mortality in Indonesia due to dengue infection is still very high. In 2005 Indonesia became the highest contributor to dengue infection in Southeast Asia (53%) with 95.270 people and 1.298 deaths.

AIM: This study aims to analyse differences in angiopoietin-2 levels in dengue hemorrhagic fever (DHF) with and without shock.

METHODS: This study was a consecutive sampling design with the research subject was obtained based on the order of admission to the hospital â€” the serum Angiopoietin-2 levels using the ELISA method. The statistical test used is the independent t-test. The value of p < 0.05 was said to be statistically significant.

RESULT: The result showed that the mean of Angiopoietin-2 levels in DHF patients with shock was higher than in DHF (p < 0.05).

CONCLUSION: This study concluded that there was a difference in the average level of Angiopoietin-2 among DHF patients with shock compared to without shock.